Human Oncology & Pathogenesis Program

The Charles Sawyers Lab

Research

Charles L. Sawyers, MD

Investigator, Howard Hughes Medical Institute; Marie-Josée and Henry R. Kravis Chair in Human Oncology and Pathogenesis; Chair, Human Oncology and Pathogenesis Program

Dr. Sawyers is investigating the signaling pathways that drive the growth of cancer cells, with an eye toward designing new treatment options for patients with chronic myeloid leukemia, prostate cancer, and glioblastoma.

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Featured News

In the Lab

New Discovery Explains How the Prostate Gland Regenerates Itself

Thursday, April 30, 2020

Q&A

Genetic Finding Can Guide Immunotherapy for Prostate Cancer

Friday, January 11, 2019

In the Clinic

The Evolution of a Lifesaving Drug: A Scientist Reflects

Thursday, March 12, 2015

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Publications

Mu P, Zhang Z, Benelli M, Karthaus WR, Hoover E, Chen CC, Wongvipat J, Ku SY, Gao D, Cao Z, Shah N, Adams EJ, Abida W, Watson PA, Prandi D, Huang CH, de Stanchina E, Lowe SW, Ellis L, Beltran H, Rubin MA, Goodrich DW, Demichelis F, Sawyers CL. SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer. Science. 2017 Jan 6;355(6320):84-88. PMCID: PMC5247742.

Abida W, Cyrta J, Heller G, Prandi D, Armenia J, Coleman I, Cieslik M, Benelli M, Robinson D, Van Allen EM, Sboner A, Fedrizzi T, Mosquera JM, Robinson BD, De Sarkar N, Kunju LP, Tomlins S, Wu YM, Nava Rodrigues D, Loda M, Gopalan A, Reuter VE, Pritchard CC, Mateo J, Bianchini D, Miranda S, Carreira S, Rescigno P, Filipenko J, Vinson J, Montgomery RB, Beltran H, Heath EI, Scher HI, Kantoff PW, Taplin ME, Schultz N, deBono JS, Demichelis F, Nelson PS, Rubin MA, Chinnaiyan AM, Sawyers CL. Genomic correlates of clinical outcome in advanced prostate cancer. Proc Natl Acad Sci U S A. 2019 May 6. PMCID: PMC6561293.

Adams EJ, Karthaus WR, Hoover E, Liu D, Gruet A, Zhang Z, Cho H, DiLoreto R, Chhangawala S, Liu Y, Watson PA, Davicioni E, Sboner A, Barbieri CE, Bose R, Leslie CS, Sawyers CL. FOXA1 mutations alter pioneering activity, differentiation, and prostate cancer phenotypes. Nature, 2019 571:408-412. doi: 10.1038/s41586-019-1318-9. Epub 2019 Jun 26.

Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL. Identification of an oncogenic RAB protein. Science. 2015 Sep 3. pii: aaa4903. [Epub ahead of print]

Robinson D, Van Allen EM, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B, Taplin ME, Pritchard CC, Attard G, Beltran H, Abida W, Bradley RK, Vinson J, Cao X, Vats P, Kunju LP, Hussain M, Feng FY, Tomlins SA, Cooney KA, Smith DC, Brennan C, Siddiqui J, Mehra R, Chen Y, Rathkopf DE, Morris MJ, Solomon SB, Durack JC, Reuter VE, Gopalan A, Gao J, Loda M, Lis RT, Bowden M, Balk SP, Gaviola G, Sougnez C, Gupta M, Yu EY, Mostaghel EA, Cheng HH, Mulcahy H, True LD, Plymate SR, Dvinge H, Ferraldeschi R, Flohr P, Miranda S, Zafeiriou Z, Tunariu N, Mateo J, Perez-Lopez R, Demichelis F, Robinson BD, Schiffman M, Nanus DM, Tagawa ST, Sigaras A, Eng KW, Elemento O, Sboner A, Heath EI, Scher HI, Pienta KJ, Kantoff P, de Bono JS, Rubin MA, Nelson PS, Garraway LA, Sawyers CL, Chinnaiyan AM. Integrative clinical genomics of advanced prostate cancer. Cell. 2015 May 21;161(5):1215-28.

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People

Charles L. Sawyers, MD

Investigator, Howard Hughes Medical Institute; Marie-Josée and Henry R. Kravis Chair in Human Oncology and Pathogenesis; Chair, Human Oncology and Pathogenesis Program

Human Oncology and Pathogenesis Program Chair Charles Sawyers develops molecularly targeted cancer therapy.
MD, Johns Hopkins University School of Medicine

sawyersc@mskcc.org: Email Address
646-888-2138: Office Phone
View physician profile: Physician profile

Members

Wassim Abida, MD, PhD — Wassim Abida
Assistant Attending, Laboratory Member

Brett Carver, MD, PhD — Brett Carver
Associate Attending

Phil Iaquinta, PhD — Phil Iaquinta
Senior Research Scientist

Philip Watson, PhD — Philip Watson
Assistant Lab Member

Zeda Zhang
Postdoctoral Researcher at Memorial Sloan Kettering Cancer Center, New York, NY

Weiran Feng, Research Fellow — Weiran Feng
Research Fellow

Elizabeth Hoover, BS — Elizabeth Hoover
Senior Research Technician

Wouter Karthaus, PhD — Wouter Karthaus
Research Assistant

Kayla Lawrence, BS — Kayla Lawrence
Senior Research Technician

Ninghui Mao, PhD — Ninghui Mao
Senior Research Assistant

Lab Alumni

Minna Balbas, MS — Minna Balbas
Clinical Scientist, Nektar Therapeutics, San Francisco, CA

Rohit Bose, MD, PhD — Rohit Bose
Research Fellow

Ling Cai

Fiona Chen, MD — Fiona Chen
Graduate Student

Daniel C. Danila, MD — Daniel C. Danila
Medical Oncology Fellow

Haley Hieronymus

Senior Research Scientist

Rajmohan Murali

Senior Research Scientist

Allison Rainer

Emily Schenkein

Research Technician

Jackline Wanjala

Research Technician

John Wongvipat, BS — John Wongvipat
Research Lab Manager

Dominique Abita
Assistant to the Chairman

Elizabeth Adams Whicher, PhD — Elizabeth Adams Whicher
Research Fellow

Danielle Choi
Senior Animal Husbandry Technician

Jennifer Harris

Fellow

Taslima Ishmael, BS — Taslima Ishmael
Research Technician

Sarala Kal

Research Technician

Eugine Lee, PhD — Eugine Lee
Research Fellow

Tejasveeta Nadkarni
Senior Research Technician

Kristina Navrazhina

NE WGS Graduate Student

Bin-Zhi Qian

Research Associate

Patrick Sullivan, BS — Patrick Sullivan
Research Technician

David Wise, MD, PhD — David Wise
Research Fellow

Valerie Wouters

Graduate Research Assistant

Andrew Kwon

Jennifer C. King

Mike Burgess

Mercedes Gorre

Derek Welsbie

Randy Chen

Brian Skaggs

Ingo Mellinghoff, MD — Ingo Mellinghoff
Lab Head

Tweeny R. Kau

Neil Shah

Betsy Katz

Alice Tam

George V. Thomas

John Nicoll

Jin Xu

Research Fellow

Tambudzai Shamu

Research Technician

Kate Ellwood-Yen

Lab Affilations

Achievements

AACR Princess Takamatsu Memorial Lectureship and Award (2019)
The Scheele Award, Swedish Academy of Pharmaceutical Sciences (2017)
American Cancer Society Medal of Honor (2017)
BBVA Foundation Frontiers of Knowledge Award (2015)
Breakthrough Prize in Life Sciences (2013)

Lasker-DeBakey Clinical Medical Research Award (2009)
Breakthrough Prize in Life Sciences (2013)
Science of Oncology Award, American Society of Clinical Oncology (2013)
Stanley J. Korsmeyer Award, American Society of Clinical Investigation (2011)
Member, National Academy of Sciences (2010)
Lasker~DeBakey Clinical Medical Research Award, Lasker Foundation (2009)
Dorothy Landon-AACR Prize for Translational Cancer Research, American Association for Cancer Research (2009)
Member, Institute of Medicine of the National Academies (2008)
David A. Karnofsky Memorial Award, American Society of Clinical Oncology (2005)

Get in Touch

sawyersc@mskcc.org

Lab Head Email
646-888-2138

Office Phone
646-888-3407

Office Fax
646-888-3462

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Charles L. Sawyers discloses the following relationships and financial interests:

Agios Pharmaceuticals
Ownership / Equity Interests; Provision of Services
Annual Review of Cancer Biology
Provision of Services
Arsenal IO Canada Parent, Inc.
Ownership / Equity Interests; Provision of Services
BeiGene, Ltd.
Ownership / Equity Interests; Provision of Services
Blueprint Medicines
Ownership / Equity Interests; Provision of Services
Column Group
Ownership / Equity Interests; Provision of Services
Diaprost AB
Intellectual Property Rights
Flagship Investments, Ltd.
Ownership / Equity Interests
Foghorn Therapeutics
Ownership / Equity Interests; Provision of Services

Harrington Discovery Institute
Provision of Services
Housey Pharmaceutical
Ownership / Equity Interests; Provision of Services
KSQ Therapeutics
Ownership / Equity Interests; Provision of Services
Nextech Venture, LTD
Ownership / Equity Interests; Provision of Services
Novartis
Fiduciary Role/Position; Ownership / Equity Interests
Oric Pharmaceuticals
Intellectual Property Rights; Ownership / Equity Interests; Provision of Services
PMV Pharma
Ownership / Equity Interests; Provision of Services
Petra Pharma Corporation
Ownership / Equity Interests; Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2019 through disclosure submission in spring 2020). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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The Charles Sawyers Lab

Research

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Publications

People

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