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Physician-scientist Samuel Singer studies the genomic alterations that define new targets for therapy in sarcoma. I am a surgical oncologist who specializes in the diagnosis and treatment of soft tissue sarcoma. I have extensive experience with this group of cancers, and am one of just a few surgeons in the world focused solely on treating sarcoma patients. My years of experience have enabled me to devise surgical techniques that improve the ability to completely remove these tumors. In addition to my clinical sarcoma practice, I conduct laboratory research to develop new methods to improve the diagnosis and treatment of sarcoma. I lead both a National Cancer Institute Specialized Program in Research Excellence (SPORE) and the Sarcoma Genome Project.

… Soft tissue sarcoma is a heterogeneous disease with more than 50 histological subtypes, which have diverse biological behavior and – in many cases – unique genetics. Many sarcoma subtypes respond poorly to chemotherapy, so there is an urgent need for better treatment options for patients whose disease

Physician-scientist David R. Jones studies molecular mechanisms governing the development of metastases in lung and esophageal cancers.

… The primary reason people die from cancer is the development of metastatic disease. As a surgeon-scientist who cares for patients with earlier stage lung and esophageal cancer, my laboratory studies why patients with completely resected cancer still develop metastases and die. We focus on a class of

The Greenbaum lab utilizes techniques from statistical physics, information theory, and evolutionary biology to better understand the role of self/non-self discrimination in tumor evolution, model response to immunotherapies, and quantify drivers of virus and cancer evolution.

… A main goal in the Greenbaum lab is to quantify how the immune system is activated and how it impacts tumor evolution. A particular focus in the lab is the role of repetitive elements in the genome, which mimic viral features and, just like viruses, evolve to escape immune surveillance. Dr. Greenbaum

Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.

… Our lab investigates the fundamental evolutionary mechanisms underlying metastasis using pancreatic cancer as our model tumor type. Metastasis is the result of a series of biological hurdles subject to Darwinian selection including the birth of metastasis-enabled cells within a heterogeneous primary

The Brown Lab studies how the tissue environment shapes immune cell fate and function during early life immune development, inflammation, and cancer.

… At the Brown Lab, we’re studying how signals from the tissue environment shape the fate and function of immune cells and the mechanisms by which the immune system reciprocally regulates tissue homeostasis and host immunity. At the heart of an immune response are dendritic cells, sentinels of the immune

Molecular biologist Prasad Jallepalli studies the mechanisms that ensure accurate chromosome transmission in human cells.

… Our laboratory is interested in how human cells accurately duplicate and transmit their chromosomes during each round of division. Prasad Jallepalli, MD, PhD Member Professor MD, PhD, Johns Hopkins University School of Medicine Achievements Phi Beta Kappa, Harvard University (1992) M.D./Ph.D. Fellow,

Molecular biologist Iestyn Whitehouse investigates chromatin structure and the function of ATP-dependent chromatin remodelling enzymes.

… The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on understanding basic mechanisms and use a combination of biochemical, molecular biological and genomics approaches

We leverage large-scale unbiased profiling including genomics, transcriptomics, proteomics to identify candidate oncogenes and proteins that are pathogenetically relevant in lymphoma.

… Kojo S. Elenitoba-Johnson is the Chair of the Department of Pathology and Laboratory Medicine and a physician-scientist. Dr. Elenitoba-Johnson’s research focuses on the role of genomic and proteomic alterations in the pathogenesis of lymphomas. Dr. Megan S. Lim is the Director of the Lymphoma Translational

Physician-scientist James Fagin focuses on the pathogenesis of thyroid cancer and the role of oncogenic kinases.

… The focus of the Fagin lab is to understand the pathogenesis and the biology of thyroid cancers at single cell resolution with the goal of identifying new mechanism-based therapies.  His group has been instrumental in characterizing somatic genetic changes associated with tumor initiation and progression

The Akhmanova laboratory studies cell invasion and migration through tissues, and how it is controlled by surrounding tissue cells.

… Welcome to the Akhmanova lab, where we study how cells penetrate and migrate through tissues in vivo . By combining cutting-edge live imaging, mechano-biological techniques, and theoretical modelling, we aim to uncover the secrets behind these intricate processes. Fig.1 Research methodology and goals