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The Lito lab investigates the properties of oncoproteins that drive cancer cell growth, with a focus on cancers driven by RAS mutations.

… The Lito lab investigates the properties of oncoproteins that drive cancer cell growth, with a focus on cancers driven by RAS mutations. RAS mutants were historically thought to be locked in an active state due to an inability to break down the nucleotide GTP. Contrary to this long-held view, we discovered

The Chiosis lab uses a unique chemical biology approach to understand, diagnose, and treat cellular processes associated with chronic molecular stress, with the ultimate goal of developing novel therapeutic options for use in the clinic.

… The goal of my program is to investigate stressor maladaptation mechanisms such as they occur in several diseases. Our approach takes advantage of the way nature has evolved to control such stressors, and that is by a unique usage of the chaperome, referred here as the epichaperome. The epichaperome,

… The Joe Chan Lab combines machine learning with disruptive single-cell sequencing and multiplex spatial imaging to study lineage plasticity in cancer, with a particular focus on histological transformation, as a mechanism of acquired resistance, immune escape, and metastasis. The lab has a special interest

Molecular pathologist Marc Ladanyi studies the molecular pathogenesis of sarcomas, lung cancer, and mesothelioma.

… The research program in this laboratory focuses on the genomics and molecular pathogenesis of sarcomas and thoracic malignancies, with an emphasis on clinical translation of potential diagnostic markers and therapeutic targets. Dr. Ladanyi also co-directs (with Chris Sander) the Genome Data Analysis

The Taylor laboratory studies the influence of the nervous system on pediatric and young adult cancers.

… Our laboratory studies neuron-cancer interactions, with a focus on developmental malignancies. Using a multi-disciplinary approach within the emerging field of cancer neuroscience, we leverage neuroscience tools and techniques to interrogate the microenvironmental influence of neural circuitry on pediatric

The Long laboratory investigates the molecular mechanisms of ion channels and enzymatic membrane proteins and seeks to use these discoveries to benefit humanity.

… Our laboratory uses a combination of structural biology and biophysical techniques to discover how ion channels and membrane-embedded enzymes function at the atomic level. The proteins we study are crucial for the function of the immune system, vision, cell differentiation, and embryonic development,

Physician-scientist Luke R.G. Pike studies the mechanistic underpinnings of brain metastasis and seeks to identify translational correlates with outcomes following local or systemic therapy.

… The Luke Pike Lab seeks to understand the unique biology of brain metastasis (BrM) and to improve outcomes for patients afflicted with this terrible disease. BrM is an exceptionally common form of solid tumor metastasis, affecting approximately 400,000 U.S. cancer patients each year. The mechanisms by

Molecular biologist John Petrini investigates the repair of chromosomal breaks and the activation of the DNA-damage-induced cell-cycle checkpoints.

… Work in our laboratory is focused on understanding the molecular transactions that govern chromosome stability and replication. The association of cancer predisposition and other pathology with mutations that affect chromosomal metabolism forms the basis of our interest in this process. In this regard

Cancer biologist Tuomas Tammela investigates cellular heterogeneity in lung and pancreatic cancers.

… The Tammela lab is interested in understanding the remarkable phenotypic heterogeneity of cancer cells within tumors. We approach this question using a combination of sophisticated genetically engineered mouse models, single-cell approaches, tracing and ablation of distinct tumor cell lineages, CRISPR-mediated

The Maura Lab is an energetic, highly collaborative, in-person team that combines clinical, computational, and molecular biology—leveraging bulk and single-cell genomics and close MSKCC clinical partnerships—to uncover genomic drivers of lymphoproliferative disorders and translate them into earlier detection and more personalized treatments.

… The Maura Lab integrates clinical, computational, and molecular biology to understand lymphoproliferative disorders. In particular, we identify genomic and immune drivers for initiation, progression, and treatment response. Using bulk and single-cell sequencing approaches, we develop strategies for early