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The Diver lab studies the physiological roles and molecular mechanisms of understudied membrane-embedded proteins with the goal of revealing novel therapeutic targets for diseases such as pain and cancer.

… Most drugs target membrane proteins, accessible on the surface of cells, to alter the transport of ions and molecules and the transduction of cellular signals. The Diver lab explores the biological functions and molecular mechanisms of understudied transmembrane protein families with the goal of revealing

Cell biologist Marilyn Resh investigates the regulation of protein function by fatty acylation, and the development of Hedgehog palmitoylation inhibitors to block pancreatic and lung cancer.

… The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins. Marilyn Resh, PhD Member PhD, Harvard University AB, Princeton

The Functional MRI Laboratory provides pre-operative planning for patients with brain tumors and studies the clinical applications of advanced neuroimaging techniques for brain tumor imaging.

… Our lab utilizes functional, diffusion, and perfusion MRI to provide pre-operative planning for patients with brain tumors. The goal of our work is to identify key areas of the brain, such as areas for language, motor, sensory, and auditory function, prior to treatment so that neurosurgical interventions

The Gabrielle Rizzuto lab investigates a long-standing question in immunology: what prevents maternal immune rejection of the placenta and fetus?

… The Gabrielle Rizzuto lab investigates a long-standing question in immunology: what prevents maternal immune rejection of the placenta and fetus? The immune system must be able to discriminate self from non-self. Pregnancy is a beautiful exception to the paradigm that non-self is immunogenic, since the

Molecular pathologist Marc Ladanyi studies the molecular pathogenesis of sarcomas, lung cancer, and mesothelioma.

… The research program in this laboratory focuses on the genomics and molecular pathogenesis of sarcomas and thoracic malignancies, with an emphasis on clinical translation of potential diagnostic markers and therapeutic targets. Dr. Ladanyi also co-directs (with Chris Sander) the Genome Data Analysis

The Long laboratory investigates the molecular mechanisms of ion channels and enzymatic membrane proteins and seeks to use these discoveries to benefit humanity.

… Our laboratory uses a combination of structural biology and biophysical techniques to discover how ion channels and membrane-embedded enzymes function at the atomic level. The proteins we study are crucial for the function of the immune system, vision, cell differentiation, and embryonic development,

Physician-scientist Luke R.G. Pike studies the mechanistic underpinnings of brain metastasis and seeks to identify translational correlates with outcomes following local or systemic therapy.

… The Luke Pike Lab seeks to understand the unique biology of brain metastasis (BrM) and to improve outcomes for patients afflicted with this terrible disease. BrM is an exceptionally common form of solid tumor metastasis, affecting approximately 400,000 U.S. cancer patients each year. The mechanisms by

… The Joe Chan Lab combines machine learning with disruptive single-cell sequencing and multiplex spatial imaging to study lineage plasticity in cancer, with a particular focus on histological transformation, as a mechanism of acquired resistance, immune escape, and metastasis. The lab has a special interest

Cancer Immunologist Andrea Schietinger investigates immune responses to cancer, molecular mechanisms underlying tumor-induced T cell dysfunction, and new approaches for cancer immunotherapy.

… The goal of our laboratory is to understand when, why, and how immune cells become unresponsive to tumors or self-destructive in autoimmune diseases. We develop genetic cancer mouse models that mimic cancer development in patients, investigate T cell responses over the course of tumor development, and

Biochemist and Bioengineer Kayvan Keshari explores changes in cancer metabolism to develop advanced imaging techniques and cancer therapeutics.

… The goal of our research program is to improve our biochemical understanding of cancer metabolism and use metabolic changes to develop non-invasive methods for diagnosis as well as approaches to treat cancer. Our work takes advantage of multi-modality methods at all scales, with a special focus in hyperpolarized