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The Romesser lab studies colorectal and anal cancer with a focus on using radiotherapy to treat disease.

… Research of the Paul Romesser Laboratory focuses on three main concepts. First is the characterization of the processes of senescence. This includes senescence-associated secretory phenotype (SASP) induction and tumor microenvironment (TME) remodeling in response to radiation. Similarly, we seek to investigate

The Reznik Lab studies metabolic and mitochondrial dysfunction in cancer through analysis of multimodal genetic, metabolomic, and clinical data.

… The Reznik Lab studies metabolic and mitochondrial dysfunction in cancer through analysis of multimodal genetic, metabolomic, and clinical data. We use computational tools to address a basic question: how do tumors adapt their metabolism, the process by which they obtain energy and nutrition from the

Physician-scientist Christopher A. Klebanoff studies T cell immunobiology with an emphasis on adoptive T cell immunotherapy for the treatment of solid malignancies.

… A form of cancer immunotherapy termed adoptive T cell transfer (ACT), in which a patient’s own T cells are engineered to recognize and attack cancer cells, can induce durable complete remissions in patients with advanced hematologic malignancies. By contrast, a similar approach has thus far failed to

Molecular biologist Scott Keeney investigates mechanisms of the initiation of meiotic recombination.

… The long-range objectives of our research are to understand the mechanism of meiotic recombination and to determine how this process is coordinated with other events of meiotic prophase. Several projects in the lab focus on Spo11 (the protein that makes the DNA double-strand breaks (DSBs) that initiate

Physician-scientist Richard Wong studies the mechanisms of cancer cell chemotaxis in perineural invasion.

… Perineural invasion (PNI) is an ominous form of cancer progression in which cancer cells invade and track along nerves. PNI occurs most frequently in cancers that affect highly innervated organs, including pancreatic, head and neck, and prostate cancers. It is associated with increased recurrence and

The Aviram Lab investigates the molecular mechanisms that protect microorganisms from their own pathogenic invaders.

… Like any other organism, bacteria are constantly exposed to pathogenic threats, such as viruses and plasmids. The Aviram Lab is interested in understanding how bacterial cells protect themselves from invaders, focusing particularly on the CRISPR-Cas adaptive immune system. CRISPR-Cas systems have a remarkable

The Sfeir Lab investigates pathways that ensure genome fidelity and plasticity.

… Chromosomes are the fundamental structural units of our genome. The Sfeir lab seeks to understand basic chromosome biology and how their mismanagement manifests in disease. Our research is focused on three major areas: telomere maintenance, nuclear DNA repair, and mitochondrial DNA replication and repair

Biostatistician Colin Begg has research interests spanning cancer epidemiology and statistical methods that are applicable to clinical research more broadly.

… Dr. Begg has research interests spanning cancer epidemiology and statistical methods that are applicable to clinical research more broadly. In recent years Dr. Begg has been developing methods to identify etiologically distinct cancer sub-types, statistical tests of clonal relatedness of pairs of tumors

Medical physicist John Humm focuses on noninvasive imaging of the tumor microenvironment using nuclear imaging methods.

… I am head of the nuclear medicine physics section, which supports research in PET/CT, targeted therapies, and molecular imaging. As both a medical and biophysicist, I investigate nuclear imaging methodologies to define tumor targets in terms of their metabolic and microenvironmental properties. I have

Chemical Biologist Minkui Luo develops cutting-edge tools, technologies and concepts to annotate functions of protein-posttranslational modifications and designs inhibitors for cancer therapies.

… The Luo Lab is interested in developing and leveraging novel approaches at the interface of chemistry and biology to annotate functional roles of epigenetic modulators. Epigenetic regulation is essential for maintaining cellular fates and its dysregulation has been associated with various diseases including