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The Aviram Lab investigates the molecular mechanisms that protect microorganisms from their own pathogenic invaders.

… Like any other organism, bacteria are constantly exposed to pathogenic threats, such as viruses and plasmids. The Aviram Lab is interested in understanding how bacterial cells protect themselves from invaders, focusing particularly on the CRISPR-Cas adaptive immune system. CRISPR-Cas systems have a remarkable

Yael David’s lab develops and applies methods in chemical biology toward studying epigenetic regulation and its correlation with disease states.

… Research efforts in the David lab apply core techniques in chemical biology, biochemistry, and cell biology to address fundamental questions in the epigenetic regulation of transcription. Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone

Our team is focused on developing novel tools and approaches for the diagnosis and treatment of cancer using genomics as a guide.

… Our team is focused on developing novel tools and approaches for the diagnosis and treatment of cancer using genomics as a guide. Luis Diaz Jr., MD Head of the Division of Solid Tumor Oncology; Grayer Family Chair MD, University of Michigan Email [email protected] Office phone 646-888-4641

Physician-scientist Liang Deng studies poxvirus interface with the immune system and the development of poxviruses as oncolytic and immunotherapy for cancers.

… Our laboratory is focused on understanding how poxviruses are detected by the host innate immune sensing mechanisms and how poxviruses evade host antiviral responses. We are also interested in the development of poxvirus-based oncolytic and immunotherapy for cancers including melanoma. Liang Deng, MD

Computational biologist Dana Pe’er combines single-cell and spatial profiling technologies with machine learning approaches to address fundamental questions in gene regulation, cellular plasticity and cell-cell communication in the contexts of cancer, immunity and development.

… The Pe’er lab is an interdisciplinary group that combines advanced genomics approaches with machine learning to address fundamental questions in biomedical science. Empowered by potent technologies such as single-cell genomics and imaging-based molecular profiling, we analyze complex data to understand

Molecular biologist Xiaolan Zhao studies chromosomal organization, genome integrity, DNA replication and repair, dynamic protein modification.

… DNA replication, repair, and damage response, collectively called the 3Rs, support genome stability and faithful genetic inheritance. Proteins involved in the 3Rs are genome guardians that prevent a broad spectrum of diseases, ranging from cancers, immunological and neurodegenerative diseases, to developmental

Physician-scientist Emily Cheng studies the molecular mechanisms of cell death and their implications in tumorigenesis, tumor-microenvironment interactions, targeted therapy, and immunotherapy.

… The focus of the Cheng laboratory is to elucidate the molecular mechanisms of cell death with an overarching goal of directly translating cell death mechanisms into novel anti-cancer therapeutic strategies that can effectively trigger cancer cell death and enhance anti-cancer immunity. Emily H. Cheng

We take real-world data, clean it and use it to discover new predictive biomarkers to guide cancer management (often with AI), and then implement these findings in clinical practice.

… AI and real-world data are alluring tools, which may transform the practice of oncology. But the integration and application of these tools to cancer research and clinical care has to improve at every step before they can meaningfully improve the lives of patients.  To develop useful biomarkers, we need

Surgeon scientist Vinod Balachandran develops novel immunotherapies for pancreatic cancer.

… Our goal is to discover new ways to stimulate the immune system to treat cancer. We study pancreatic cancer, a model deadly cancer that is refractory to all immunotherapies, as well as nearly all other treatments. We use reverse translation to uncover the biological basis of exceptional response in rare

Physician-scientist Ping Chi studies genetic and epigenetic mechanisms of transcriptional regulation by oncogenic factors in GIST, MPNST, melanoma and other solid tumors.

… It is well recognized that the cellular context contributes to susceptibility to oncogenic transformation mediated by different “driver” oncogenes. The focus of our laboratory is to discover and understand the critical genetic and epigenetic factors that determine the cellular-context-dependent oncogenesis