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The Mara Sherman lab aims to understand the heterocellular interactions among pancreatic cancer cells and their surrounding microenvironment, and to target these networks for therapeutic benefit.

… The Mara Sherman lab aims to understand the heterocellular interactions among pancreatic cancer cells and their surrounding microenvironment, and to target these networks for therapeutic benefit. Our research focuses on the tumor-permissive molecular mechanisms underlying cancer-associated fibroblast

We develop and clinically deploy novel computational algorithms for analyzing multiscale, multimodal biomedical imaging data.

… The Nadeem Lab analyzes, interprets, and infers novel insights from biomedical data at multiple scales (macro: radiology/ surgery, meso: pathology, micro: genomics/ transcriptomics/ proteomics/ metabolomics) for improving patient outcomes. We use advanced mathematical and machine learning techniques

Physician-scientist Adrienne Boire studies metastasis to the central nervous system.

… The Boire lab studies leptomeningeal metastasis as a means to understand the principles of metastasis as well as the nervous system’s relationship to the larger organism. Adrienne A. Boire, MD, PhD Scientific Director, Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center Associate Professor PhD

Heeseon An’s lab studies protein degradation in health and disease using chemical, biological, and proteomics tools.

… The research in An lab centers around protein degradation processes in health and disease. We investigate protein degradation processes using chemical biology tools and unbiased proteomic approaches to discover previously unknown degradational pathways and molecular mechanisms. Specific research areas

Mechanisms of genetic and epigenetic cooperativity which drive myeloid transformation; Elucidating and modeling evolution from hematopoietic stem/progenitor cells to clonal hematopoiesis and then to myeloid malignancies; Identification and credentialing novel therapeutic dependencies in myeloid malignancies

… The goal of our research is to improve our understanding of the genetic basis of blood disorders known as myeloid malignancies, and to use this knowledge to improve therapies for patients with these disorders. Our efforts are focused on the identification and characterization of somatic mutations in

Physician-scientist Tobias Hohl studies the molecular pathogenesis of human fungal pathogens and how the immune system responds to them.

… The focus of my research program is to decipher the molecular and cellular basis of immunity against Candida and Aspergillus species , major causative agents of invasive mycoses in patients with cancer. We have developed fluorescence-based reporters of fungal physiology to examine the outcome of fungal

Physician-scientist Sarat Chandarlapaty studies the regulation of growth factor signaling networks in cancer.

… The goal of our research program is to understand the detailed mechanisms by which a cancer cell can develop resistance to therapies targeting its oncogenic driver; and to exploit those findings to elucidate the biology of cancer and identify more effective treatments for cancer patients. The focus of

The Nikolov laboratory focuses on the structural, biophysical, and biochemical characterization of the molecular mechanisms of cell-cell interactions and signal transduction across the plasma membrane.

… Research in our laboratory aims to characterize the molecular mechanisms underlying cell-to-cell interactions and signal transduction across the cell membrane. We are particularly interested in understanding how receptors located on the surface of developing axons and neurons interact with extracellular

Surgeon scientist Vinod Balachandran develops novel immunotherapies for pancreatic cancer.

… Our goal is to discover new ways to stimulate the immune system to treat cancer. We study pancreatic cancer, a model deadly cancer that is refractory to all immunotherapies, as well as nearly all other treatments. We use reverse translation to uncover the biological basis of exceptional response in rare

Physician-scientist Ping Chi studies genetic and epigenetic mechanisms of transcriptional regulation by oncogenic factors in GIST, MPNST, melanoma and other solid tumors.

… It is well recognized that the cellular context contributes to susceptibility to oncogenic transformation mediated by different “driver” oncogenes. The focus of our laboratory is to discover and understand the critical genetic and epigenetic factors that determine the cellular-context-dependent oncogenesis