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Our group, the Laboratory of Experimental Cancer Immunogenomics, is a multi-disciplinary team of cancer scientists working at the intersection of genomics, molecular genetics, animal modeling, and biostatistical data sciences.

… Our group, the Laboratory of Experimental Cancer Immunogenomics, is a multi-disciplinary team of cancer scientists working at the intersection of  genomics ,  molecular genetics ,  animal modeling, and biostatistical data sciences . We are a mix of experienced researchers, postdoctoral fellows, clinical

The Wilkinson laboratory studies reverse transcriptases and retrotransposons using biochemistry, structural biology, and genome mining.

… Genetic information typically flows in one direction: from DNA to RNA to protein. Our lab is fascinated by reverse transcription, where this flow is flipped on its head, allowing RNA to be rewritten back into DNA. Reverse transcriptases are famously used by retroviruses like HIV to invade genomes, but

Molecular biologist Dirk Remus investigates mechanisms of DNA replication in eukaryotic cells.

… Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental importance for genome maintenance during normal cell proliferation. We employ fully reconstituted yeast and

Physician-scientist Martin Weiser investigates the mechanisms underlying tumor spread and metastasis and how these mechanisms could be targeted.

… Our research investigates the natural history, molecular biology, and treatment response of cancers of the rectum and colon with the goal of personalizing therapy to reduce treatment toxicity, increase survival, and improve post-treatment quality of life.  We have built and tested clinical calculators

The Diver lab studies the physiological roles and molecular mechanisms of understudied membrane-embedded proteins with the goal of revealing novel therapeutic targets for diseases such as pain and cancer.

… Most drugs target membrane proteins, accessible on the surface of cells, to alter the transport of ions and molecules and the transduction of cellular signals. The Diver lab explores the biological functions and molecular mechanisms of understudied transmembrane protein families with the goal of revealing

Physician-scientist Vladimir Ponomarev focuses on developing reporter genetic systems for specific applications such as sequential in vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences.

… I am a physician-scientist who focuses on the development of new multi-modal imaging approaches for specific applications, such as sequential in vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences. Vladimir Ponomarev, MD, PhD Office phone 646-888-2213

… About the Scott Lowe Lab Cancer biologist Scott Lowe uses genetically engineered mouse models to study how the genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response, and create molecular vulnerabilities that may be targeted therapeutically. Cancer arises through an

Systems biologist Joao Xavier combines experimental and computational approaches to study diverse problems relevant to cancer: how the microbiome influences cancer and cancer treatment, how cancer cells metastasize, and how metabolic fluxes command the behavior of living cells.

… We combine computation and experiment to investigate how cells interact with each other to produce complex cell group behaviors. Joao Xavier, PhD Member, Computational & Systems Biology Program Professor PhD, Universidade Nova de Lisboa Achievements Director's New Innovator Award, National Institutes

Physician-scientist David Solit studies human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.

… Our research is based on the underlying hypothesis that the ability to inhibit an oncogenic pathway and block cancer growth will vary based on cell lineage and the complement of mutations within the tumor. To design rational therapeutic studies, we must define not only the spectrum of genetic changes

Cell biologist Marilyn Resh investigates the regulation of protein function by fatty acylation, and the development of Hedgehog palmitoylation inhibitors to block pancreatic and lung cancer.

… The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins. Marilyn Resh, PhD Member PhD, Harvard University AB, Princeton