Emmanouil P. Pappou, MD, PhD, FASCRS

About Me

I am a board-certified colorectal surgeon who specializes in treating gastrointestinal cancers. Specifically, I focus on colon cancer, rectal cancer, appendiceal cancer, and anal cancer. I have extensive experience doing traditional open surgery and using minimally invasive techniques, such as robotic and laparoscopic surgery. I work closely with my patients, their families, and my colleagues across many disciplines to come up with a treatment plan that best fits my patients’ needs. As a surgeon, I aim to minimize the risks of cancer surgery while having a meaningful, positive impact on my patients’ quality of life.

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I was drawn to the field of surgical oncology and specifically colorectal surgery for several reasons. I admired the dual commitment of a colorectal surgeon to saving lives while at the same time striving to preserve quality of life. I also find it most rewarding to see people get their lives back after they have completed their cancer treatments.

People being treated for colorectal cancer often need to face issues that may be difficult to talk about, such as bowel and sexual function. For this reason, my team and I approach each patient as a member of our family. We treat them with the dignity and respect they deserve. We’ll spend as much time together as needed to ensure that everyone is at ease with our plan moving forward.

Our number-one goal is to cure cancer, but we place equal importance on our patients’ quality of life. That’s why we are developing clinical trials that look at ways to restore or improve function after surgery for colorectal cancer. We’re also developing new tools for early detection and treatment of colorectal and anal cancer.

No two people have the same expectations of surgery. Taking the time to get to know my patients helps me fine-tune the procedure to meet their needs. My team and I are easily accessible and readily available to answer any questions that my patients may have. We are here to guide them and their families before, during, and after surgery.

  • Clinical Expertise: Gastrointestinal Cancers; Primary and Recurrent Colon, Rectal, Anal, Appendiceal and Small Bowel Cancers; Carcinoid; Peritoneal Surface Malignancies; Minimally Invasive Surgery Robotic and Laparoscopic Colorectal Surgery; Preservation of Bowel, Bladder, and Sexual Function in Patients with Cancer; Clinical Trials in Surgery
  • Awards and Honors: Johns Hopkins Department of Surgery Core Values in Practice Award (2009); Johns Hopkins George D. Zuidema Research Award for Meritorious Laboratory Research (2010)
  • Languages Spoken: English; French; German; Greek
  • Education: MD, Technical University of Munich; PhD, Ludwig-Maximilians-University of Munich
  • Residencies: Surgery – Johns Hopkins Hospital
  • Fellowships: Surgical Oncology - The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University; Colon and Rectal Surgery – NewYork-Presbyterian Hospital/Memorial Sloan Kettering Cancer Center
  • Board Certifications: Surgery; Colon and Rectal Surgery

See My Colleagues


Pappou, E.P. and M.R. Weiser, Robotic colonic resection. J Surg Oncol, 2015

Fu, T., E.P. Pappou, A.A. Guzzetta, M.F. Calmon, L. Sun, A. Herrera, F. Li, C.L. Wolfgang, S.B. Baylin, C.A. Iacobuzio-Donahue, W. Tong, and N. Ahuja, IGFBP-3 Gene Methylation in Primary Tumor Predicts Recurrence of Stage II Colorectal Cancers. Ann Surg, 2015.

Tao Fu, Yanliang Liu, Kai Li, Weiwei Wan, Emmanouil Pappou, Christine Iacobuzio-Donahue, Zachary Kerner, Stephen Baylin, Christopher Wolfgang, and Nita Ahuja.Tumors with unmethylated MLH1 and the CpG island methylator phenotype are associated with a poor prognosis in stage II colorectal cancer patients. Oncotarget 2016.

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Visit PubMed for a full listing of Emmanouil P. Pappou’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Clinical Trials

As home to one of the world’s top cancer research centers, Memorial Sloan Kettering is typically involved in more than 900 clinical trials at a given time. Currently, clinical trials focused on the conditions I treat are enrolling new patients. If you’re interested in joining a clinical trial, click to learn about the trial’s purpose, eligibility criteria, and how to get more information.

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Most major health insurers offer plans that include MSK as one of their in-network providers. If MSK is in-network, it means all our doctors are too. Medicaid and New York State Medicare also provide benefits for care at MSK.

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