Saad Z. Usmani, MD, MBA, FACP
Myeloma Specialist & Cellular Therapist
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Areas of Expertise
My Specialties
- Plasma Cell Disorders
- Monoclonal Gammopathy of Undetermined Significance (MGUS)
- Smoldering Myeloma
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About Me
- Chief, Myeloma Service
I am a hematologist-oncologist specializing in the care of patients with multiple myeloma and other disorders affecting plasma cells (the cells that produce the antibodies that protect us against infection). I treat patients who have received a diagnosis of multiple myeloma or a diagnosis of another plasma cell disorder, such as monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma, or amyloidosis. Many of the patients I see have a disease that has been deemed hard to treat or high risk.
A blood cancer diagnosis dramatically changes the trajectory of a patient’s life. I am acutely aware of the impact that I have on a patient’s cancer treatment journey and am passionate about having the opportunity to make a difference in my patients’ lives. Throughout my 14-plus years of caring for patients with multiple myeloma and plasma cell disorders, my patients and their family members have always been the most important people in the room for me. It is my responsibility to educate my patients with relevant information about their disease, alleviate their concerns at each stage in the process, and develop a treatment plan that best befits their individual needs. This is not a responsibility that I take lightly. I am committed to making each of my patients feel comforted in the expertise of their care team and empowered by the information provided to them.
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Recent advances in immunotherapy (a type of cancer treatment that uses a patient’s immune system to attack cancer cells in much the same way that it attacks bacteria or viruses) and small molecule therapy are helping to change the outlook for patients with multiple myeloma and other plasma cell disorders. I am excited by the prospect of developing new therapeutic strategies for the treatment and management of these diseases and have been involved with the clinical development of several therapies approved by the FDA for patients with multiple myeloma and other blood cancers.
In addition to novel therapies, my research also centers on the use of minimal residual disease (MRD) testing to guide treatment decisions, developing new approaches for patients with high-risk disease, and establishing methods to recognize patients whose disease will progress from an early precursor disease that does not require treatment to an active disease that does.
Outside of the clinic and the lab, I can likely be found training for a race or an endurance event to raise moneys for cancer research. My most memorable fundraisers so far have been the Mount Everest Base Camp trek in 2018, the Boston Marathon in 2019, and the recently completed 2021 New York City Marathon.
A myeloma specialist is a doctor with special training in diagnosing and treating myeloma.
A cellular therapy specialist is a doctor with special training in using cell therapies to treat health conditions such as cancer. Therapies can include chimeric antigen receptor (CAR) T cell therapy.
My Specialties
- Plasma Cell Disorders
- Monoclonal Gammopathy of Undetermined Significance (MGUS)
- Smoldering Myeloma
- Multiple Myeloma
- Amyloidosis
- Bone Marrow Tranplantation
- Stem Cell Transplantation
- Immunotherapy
Education
- MBBS, Allama Iqbal Medical College
Residencies
- Internal Medicine - Sinai-Grace Hospital/Wayne State University
Awards and Honors
- LLS Scholar in Clinical Research Award (2017-2022)
- Celgene Young Investigator Award for Clinical Research in Hematology (2018)
- Vice-Chair, ASH Scientific Committee on Plasma Cell Neoplasia (2019)
- Chair, ASCO Educational Program Committee on Plasma Cell Disorders (2019)
- Chair, ASH Scientific Committee on Plasma Cell Neoplasia (2020)
- Chair, ASCO Educational Program Committee on Plasma Cell Disorders (2021)
- Vice-Chair, SWOG Barlogie-Salmon Myeloma Committee (2020-present)
- Multiple Myeloma Excellence in Clinical Research Award, COMy Congress (2020)
- Bart Barlogie Young Investigator Award in Clinical and Translational Research, 18th International Myeloma Workshop, Vienna, Austria (2021)
Fellowships
- Hematology & Medical Oncology - University of Connecticut Health Center
Board Certifications
- ABIM Internal Medicine, Hematology & Medical Oncology
Insurance Information
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If you don't have health insurance or are worried that your care may not be fully covered, our financial assistance programs may be able to help.
If you have questions about insurance, call us at 646-497-9176.
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New Patients
Current Patients
Contact and Location
Dr. Usmani sees patients at two locations.
Looking to see a doctor at a different location? See all MSK locations.
Colleagues
Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.
Clinical Trials
- Clinical Trials Investigated by Dr. Usmani
- A Phase 1 Study of ABBV-453 in People with Recurrent or Persistent Multiple Myeloma
- A Phase 1 Study of CC-92328 Immunotherapy in People with Persistent or Recurrent Multiple Myeloma
- A Phase 1 Study of KTX-1001 in People With Multiple Myeloma
- A Phase 2 Study of Leflunomide in African-American and European-American People with High-Risk Smoldering Multiple Myeloma
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- A Phase 3 Study Comparing VRd (Bortezomib, Lenalidomide, and Dexamethasone) Followed by Cilta-Cel CAR T Cell Therapy versus VRd Followed by Rd (Lenalidomide and Dexamethasone) in People with Multiple Myeloma
- A Phase IB Study of Cetrelimab plus Talquetamab or Teclistamab in People with Multiple Myeloma
- A Phase IB/IIA Study of CC-92480 in Combination with Other Anticancer Drugs in People with Multiple Myeloma
- Clinical Trials Co-Investigated by Dr. Usmani
- A Phase 1/2 Study of BGB-11417 Given Alone and With Carfilzomib and/or Dexamethasone to Treat Multiple Myeloma
- A Phase I Study of MCARH109 and MCARH125 CAR T-Cell Therapy in People with Multiple Myeloma
Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.
You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.
Search clinical trialsResearch and Publications
Visit PubMed for a full listing of Dr. Usmani’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.
See all on PubMedPatient Reviews
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Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Saad Z. Usmani discloses the following relationships and financial interests:
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AbbVie
Professional Services and Activities -
Bristol-Myers Squibb
Professional Services and Activities -
Genzyme
Professional Services and Activities -
GlaxoSmithKline
Professional Services and Activities -
Gracell Biotechnologies Ltd.
Professional Services and Activities
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Janssen Biotech, Inc.
Professional Services and Activities -
Merck & Co Inc.
Professional Services and Activities -
Novartis
Professional Services and Activities -
Pfizer, Inc.
Professional Services and Activities
If you’re a patient at MSK and would like more information about your doctor’s external relationships, please talk with your doctor.
The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].
