Samuel Singer, MD, FACS -- Chief, Gastric and Mixed Tumor Service

Samuel Singer, MD, FACS

Surgical Oncologist


Chief, Gastric and Mixed Tumor Service; Vincent Astor Chair of Clinical Research

Clinical Expertise

Soft Tissue Sarcomas; Gastrointestinal Stromal Tumor; Malignant Peripheral Nerve Sheath Tumor; Desmoid Tumor

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Accepted Insurance Providers

Dr. Singer accepts the following list of insurance providers. Select your insurance provider to see more details.

Contact and Location

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Find a Convenient Location

Memorial Sloan Kettering has locations throughout New York City, Long Island, New Jersey, and Westchester. These locations offers many services, including screening, chemotherapy, and medical testing.

About Me


MD, Harvard University


General Surgery - Brigham and Women's Hospital


Oncology - Francis Bitter National Magnet Laboratory/

Board Certifications


I am a surgical oncologist who specializes in the diagnosis and treatment of soft tissue sarcoma. I have extensive experience with this group of cancers, and am one of just a few surgeons in the world focused solely on treating sarcoma patients. My years of experience have enabled me to devise surgical techniques that improve the ability to completely remove these tumors.

I also have special expertise and experience in multimodality treatment, in which carefully planned surgery is combined, when appropriate, with radiation, chemotherapy, or targeted therapy.

I lead the Soft Tissue Sarcoma Disease Management Team at Memorial Sloan Kettering, which is a multidisciplinary group of soft tissue pathologists, medical oncologists, and radiation oncologists who work closely together to provide the best treatment plan for each individual patient.

A challenge in treating soft tissue sarcomas is that there are more than 50 subtypes, each of which is relatively uncommon. Patients’ outcomes are generally substantially better when they are managed by the sort of multidisciplinary team of experts that we can provide, in a center of excellence that treats many people with sarcoma. Our team of soft tissue sarcoma experts likely has the most extensive experience with these tumors of any medical group in the world.

In addition to my clinical sarcoma practice, I conduct laboratory research to develop new methods to improve the diagnosis and treatment of sarcoma. I lead both a National Cancer Institute Specialized Program in Research Excellence (SPORE) and the Sarcoma Genome Project.

The immediate goal of our research is to increase our understanding of sarcoma biology by discovering the alterations in DNA and RNA that cause sarcomas to develop and progress. These findings allow us to improve both the accuracy of diagnosis and the accuracy of predicting treatment outcome and survival for individual patients. These better predictions, in turn, will make it possible for patients to be given the treatment (such as a specific targeted therapy, chemotherapy, or radiation) most likely to be effective for their particular tumor.

Another goal of the research is to find new targeted therapies aimed specifically at alterations in particular tumor types. Examples of targeted therapies that I have been actively involved in developing and designing include anti-angiogenesis therapy for soft tissue sarcoma, imatinib (Gleevec®) for gastrointestinal stromal sarcoma, and cell cycle kinase inhibitor therapies (CDK4, AURKA, and PLK1), demethylating agents, HDAC inhibitors, and PPAR gamma ligands for various liposarcomas.

I am optimistic that this research will ultimately improve survival and quality of life for patients with soft tissue sarcoma.


Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

Clinical Trials

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Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

Research and Publications

View Dr. Singer's Lab

Publications on PubMed

Visit PubMed for a full listing of Dr. Singer’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.