Samuel Singer, MD, FACS

About Me

I am a surgical oncologist who specializes in the diagnosis and treatment of soft tissue sarcoma. I have extensive experience with this group of cancers, and am one of just a few surgeons in the world focused solely on treating sarcoma patients. My years of experience have enabled me to devise surgical techniques that improve the ability to completely remove these tumors.

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I also have special expertise and experience in multimodality treatment, in which carefully planned surgery is combined, when appropriate, with radiation, chemotherapy, or targeted therapy.

I lead the Soft Tissue Sarcoma Disease Management Team at Memorial Sloan Kettering, which is a multidisciplinary group of soft tissue pathologists, medical oncologists, and radiation oncologists who work closely together to provide the best treatment plan for each individual patient.

A challenge in treating soft tissue sarcomas is that there are more than 50 subtypes, each of which is relatively uncommon. Patients’ outcomes are generally substantially better when they are managed by the sort of multidisciplinary team of experts that we can provide, in a center of excellence that treats many people with sarcoma. Our team of soft tissue sarcoma experts likely has the most extensive experience with these tumors of any medical group in the world.

In addition to my clinical sarcoma practice, I conduct laboratory research to develop new methods to improve the diagnosis and treatment of sarcoma. I lead both a National Cancer Institute Specialized Program in Research Excellence (SPORE) and the Sarcoma Genome Project.

The immediate goal of our research is to increase our understanding of sarcoma biology by discovering the alterations in DNA and RNA that cause sarcomas to develop and progress. These findings allow us to improve both the accuracy of diagnosis and the accuracy of predicting treatment outcome and survival for individual patients. These better predictions, in turn, will make it possible for patients to be given the treatment (such as a specific targeted therapy, chemotherapy, or radiation) most likely to be effective for their particular tumor.

Another goal of the research is to find new targeted therapies aimed specifically at alterations in particular tumor types. Examples of targeted therapies that I have been actively involved in developing and designing include anti-angiogenesis therapy for soft tissue sarcoma, imatinib (Gleevec®) for gastrointestinal stromal sarcoma, and cell cycle kinase inhibitor therapies (CDK4, AURKA, and PLK1), demethylating agents, HDAC inhibitors, and PPAR gamma ligands for various liposarcomas.

I am optimistic that this research will ultimately improve survival and quality of life for patients with soft tissue sarcoma.

  • Clinical Expertise: Soft Tissue Sarcomas: Liposarcoma, Gastrointestinal Stromal Tumor, Synovial Sarcoma, Leiomyosarcoma, Malignant Peripheral Nerve Sheath Tumor, Angiosarcoma, Fibrosarcoma, Desmoid Tumor, Dermatofibrosarcoma, MFH, Myxofibrosarcoma, Rhabdomyosarcoma, Ewing's Sarcoma, Extremity Sarcoma, and Retroperitoneal Sarcoma
  • Languages Spoken: English
  • Education: MD, Harvard University
  • Residencies: General Surgery - Brigham and Women's Hospital
  • Fellowships: Oncology - Francis Bitter National Magnet Laboratory/
  • Board Certifications: Surgery

My Research

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See Samuel Singer’s laboratory
research at Memorial Sloan Kettering.

Publications

Cancer Genome Atlas Network. Comprehensive and integrated characterization of adult soft tissue sarcomas. Cell 2017; 171(4): 950-965.

Mazzu YZ, Hu Y, Soni RK, Mojica KM, Qin LX, Agius P, Waxman ZM, Mihailovic A, Socci ND, Hendrickson RC, Tuschl T, Singer S. 2017. miR-193b-regulated signaling networks serve as tumor suppressors in liposarcoma and promote adipogenesis in adipose-derived stem cells. Cancer Res 2017; 77: 5728-40.

Okada T, Lee AY, Qin LX, Agaram N, Mimae T, Shen Y, O’Connor R, Lopez-Lago MA, Craig A, Miller ML, Agius P, Molinelli E, Socci ND, Crago AM, Shima F, Sander C, Singer S. Integrin-alpha10 dependency identifies RAC and RICTOR as therapeutic targets in high-grade myxofibrosarcoma. Cancer Discov 2016; 6(10): 1148-1165.

Lee AY, Agaram NP, Qin LX, Kuk D, Curtin C, Brennan MF, Singer S. Optimal percent myxoid component to predict outcome in high-grade myxofibrosarcoma and undifferentiated pleomorphic sarcoma. Ann Surg Oncol 2016; 23(3):818-25.

Tan MC, Brennan MF, Kuk D, Agaram NP, Antonescu CR, Qin LX, Moraco N, Crago AM, Singer S. Histology-based classification predicts pattern of recurrence and improves risk stratification in primary retroperitoneal sarcoma. Ann Surg 2016;263(3):593-600.

Brennan MF, Antonescu CR, Moraco N, Singer S. Lessons learned from the study of 10,000 patients with soft tissue sarcoma. Ann Surg 2014; 260:416-422.

 

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Visit PubMed for a full listing of Samuel Singer’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Clinical Trials

As home to one of the world’s top cancer research centers, Memorial Sloan Kettering is typically involved in more than 900 clinical trials at a given time. Currently, clinical trials focused on the conditions I treat are enrolling new patients. If you’re interested in joining a clinical trial, click to learn about the trial’s purpose, eligibility criteria, and how to get more information.

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Insurance

Most major health insurers offer plans that include MSK as one of their in-network providers. If MSK is in-network, it means all our doctors are too. Medicaid and New York State Medicare also provide benefits for care at MSK.

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