Brain Metastases Clinical Trials & Research

Nearly every cancer treatment available today exists because of a clinical research study, also known as a clinical trial.

In a clinical trial, doctors evaluate a new therapy or a therapy combination. They see if it is more effective than the best methods we use now. Your treatment team also can get information about your care plan from a clinical trial.

Joining a clinical trial is voluntary. The choice is entirely up to you. We have many research studies at MSK, and you will benefit from them. This is true whether you get standard treatment for metastatic brain tumors, or treatment through a clinical trial.

We are now enrolling eligible patients in a trial studying brachytherapy. It is for people who are having surgery to remove a tumor for brain cancer that returned after radiation therapy.

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8 Clinical Trials found
A Phase 2 Study of Stereotactic Radiosurgery and Standard Treatment in People With EGFR-Positive Lung Cancer That Has Spread to the Brain
Researchers want to see if giving stereotactic radiosurgery (SRS) after osimertinib is better than osimertinib alone for advanced lung cancer. The people in this study have non-small cell lung cancer (NSCLC) that metastasized (spread) to the brain. Their cancers have a mutation (change) in the EGFR gene, and they are taking or planning to take osimertinib.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 3 Study Comparing 1 Radiation Therapy Treatment Versus 3 Radiation Treatments Over a Week for Brain Metastases
The usual treatment for brain metastases (cancer that spread to the brain) is a single treatment of stereotactic radiosurgery (SRS). SRS uses special equipment to position the patient and precisely give a single large dose of radiation to a tumor.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 3 Study Comparing Proton Craniospinal Radiation Therapy With the Usual Radiation Therapy for Leptomeningeal Metastasis
Breast cancer and non-small cell lung cancer (NSCLC) can spread to the cerebrospinal fluid-filled space around the brain and spinal cord. This is called leptomeningeal metastasis (LM). The effects of LM on the nervous system can be very serious.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase I Study of Deferoxamine in People with Leptomeningeal Metastasis
Cancer that has spread from a solid tumor to the membranes lining the brain and spinal cord (leptomeninges) is called "leptomeningeal metastasis." Cerebrospinal fluid (CSF) is located between the leptomeninges, in a place called the "intrathecal space." Cancer cells within the CSF rely on iron for growth and survival. Researchers think that the study drug, deferoxamine (DFO), may be an effective treatment for leptomeningeal metastases because it helps remove iron from the body (including the CSF).
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase II Study of Cs-131 Brachytherapy for People with Brain Metastases that Have Recurred
The purpose of this study is to evaluate the safety and effectiveness of cesium-131 (Cs-131) brachytherapy in patients with brain cancer that has come back after prior radiation therapy and who will be having surgery to remove it. Brachytherapy involves the placement of radioactive seeds into the brain during surgery. The seeds remain in place permanently in the area where the tumor was removed and give off cancer-killing radiation temporarily. 
New York City, Commack, Basking Ridge, Monmouth, Nassau
A Phase II Study of Stereotactic Radiosurgery for People with Small Cell Lung Cancer that Spread to the Brain
The purpose of this study is to assess stereotactic radiosurgery (SRS) to treat people with small cell lung cancer (SCLC) who have been newly diagnosed with brain metastases (cancer that spread to the brain). SRS specifically targets a very small area of the body. By targeting the part of the brain where the cancer has spread, SRS may shrink the cancer without damaging healthy brain tissue.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Study of Sotorasib in People With Brain Metastases
Researchers are doing this study to see how well sotorasib gets into metastatic brain tumors. The people in this study have tumors in the brain that have spread there from other parts of the body. They are planning to have the brain metastases removed with surgery. In addition, their tumors have a mutation (change) in the KRAS gene (KRAS G12C+).
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Study of Trastuzumab Deruxtecan for People with Brain Cancer
Researchers want to see how much the drug trastuzumab deruxtecan (T-DXd) can get into brain tumors. The people in this study have glioblastoma or cancer that spread to the brain from other parts of the body. They are scheduled to have brain tumor surgery. In addition, their tumors express (make) a protein called HER2, which boosts cancer cell growth. Researchers want to know if T-DXd may be an effective treatment for brain cancers that express the HER2 protein.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau