Dr. Arfè’s research interests include statistical decision theory, Bayesian analysis, and reinforcement learning. Dr. Arfè collaborates with investigators in the Genito-Urinary Oncology Service and with members of the MSK Biomarker Development Program to study new blood-based biomarkers in metastatic Castrate-Resistant Prostate Cancer (mCRPC) based on circulating tumor cells. He is also collaborating with investigators in the MSK Department of Radiation Oncology to design a clinical trial of post-operative brachytherapy for early-stage endometrial cancer patients. In his current methodological research, Dr. Arfè aims to develop new adaptive group-sequential clinical trial designs that leverage data from completed studies by means of machine learning methods. In support to his research program, he has been selected to receive Developmental Funds from the Cancer Center Support Grant.