Colin Begg, PhD

Chairman, Attending Biostatistician

Colin Begg, PhD

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University of Glasgow, UK

Current Research Interests

Dr. Begg has long-standing interests in cancer epidemiology, health services research, clinical trials, and the statistical methods that support scientific studies in these disciplines. Currently his work is focused on two areas. In the first, he is developing statistical techniques for clonality assessment, used to distinguish independent second primary cancers from metastases on the basis of the somatic molecular profiles of the tumors. In the second area of investigation, he is developing methods for using somatic profiles of tumors to make inferences about the etiologic heterogeneity of tumor sub-types. He collaborates closely with various other members of the department on these projects, notably Audrey Mauguen, Irina Ostrovnaya, Venkatraman Seshan, Ronglai Shen and Emily Zabor. Dr. Begg also currently serves as Editor-in-Chief of the international scholarly journal Clinical Trials, the journal of the Society for Clinical Trials.


Selected peer-reviewed publications:

  1. Begg, CB. A strategy for distinguishing optimal cancer subtypes. International Journal of Cancer 2011;129:931-937. PMCID: PMC3043163
  2. Ostrovnaya I, Seshan VE, Begg CB. Using somatic mutation data to test tumors for clonal relatedness. Annals of Applied Statistics 2015;9:1533-1548. PMCID: PMC4649945
  3. Begg CB, Ostrovnaya I, Carniello JV, Sakr RA, Giri D, Towers R, Schizas M, De Brot M, Andrade VP, Mauguen A, Seshan VE, King TA. Clonal relationships between lobular carcinoma in situ and other breast malignancies. Breast Cancer Research 2016;18:66. PMCID: PMC4918003
  4. Mauguen A, Zabor EC, Thomas NE, Berwick M, Seshan VE, Begg CB. Defining cancer subtypes with distinctive etiologic profiles: an application to the epidemiology of melanoma. Journal of the American Statistical Association 2017;112: 54-63. PMCID: PMC5460661
  5. Begg CB, Rice MS, Zabor EC, Tworoger SS. Examining the common aetiology of serous ovarian cancers and basal-like breast cancers using double primaries. British Journal of Cancer 2017;116:1088-1091. PMCID: PMC5396122

Visit PubMed for a full listing of Colin Begg’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.