Current Research Interests
Dr. Begg has long-standing interests in cancer epidemiology, health services research, clinical trials, genetics and genomics, and the statistical methods that support scientific studies in these disciplines. He has collaborated closely with countless departmental colleagues over the years, most recently with Marinela Capanu, Angela Green, Audrey Mauguen, Irene Orlow, Irina Ostrovnaya, Venkatraman Seshan, Ronglai Shen, Allison Lipitz-Snyderman, Axel Martin and post-doctoral fellows Saptarshi Chakraborty and Zoe Guan. He serves as a scientific advisor to numerous other cancer centers and extra-mural research groups. He is a joint principal investigator of the NCI-funded international GEM study that addresses the genetic and environmental risks of melanoma and of an NCI R25 training grant. Dr. Begg also currently serves as Editor-in-Chief of the international scholarly journal Clinical Trials, the journal of the Society for Clinical Trials.
Publications
Selected peer-reviewed publications:
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Ostrovnaya I, Mauguen A, Seshan VE, Begg CB. Testing tumors from different anatomic sites for clonal relatedness using somatic mutation data. Biometrics. 2021 Mar;77(1):283-292. doi: 10.1111/biom.13256. Epub 2020 Apr 2. PMID: 32135575; PMCID: PMC8514156.
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Chakraborty S, Martin A, Guan Z, Begg CB, Shen R. Mining mutation contexts across the cancer genome to map tumor site of origin. Nat Commun. 2021 May 24;12(1):3051. doi: 10.1038/s41467-021-23094-z. PMID: 34031376; PMCID: PMC8144407.
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Begg CB, Ostrovnaya I, Geyer FC, Papanastasiou AD, Ng CKY, Sakr RA, Bernstein JL, Burke KA, King TA, Piscuoglio S, Mauguen A, Orlow I, Weigelt B, Seshan VE, Morrow M, Reis-Filho JS. Contralateral breast cancers: Independent cancers or metastases? Int J Cancer. 2018 Jan 15;142(2):347-356. doi: 10.1002/ijc.31051. Epub 2017 Sep 28. PMID: 28921573; PMCID: PMC5749409.
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Mauguen A, Begg CB. Using the Lorenz Curve to Characterize Risk Predictiveness and Etiologic Heterogeneity. Epidemiology. 2016 Jul;27(4):531-7. doi: 10.1097/EDE.0000000000000499. PMID: 27096256; PMCID: PMC5495014.
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Begg CB. A strategy for distinguishing optimal cancer subtypes. Int J Cancer. 2011 Aug 15;129(4):931-7. doi: 10.1002/ijc.25714. Epub 2010 Nov 18. PMID: 20949563; PMCID: PMC3043163.
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