Mithat Gönen, PhD

Chief, Biostatistics Service

Pictured: Mithat Gönen

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Texas Tech University

Dr. Gönen has been at MSK since 1999 and has been serving as Chief of the Biostatistics Service since 2015. His translational and clinical collaborations focus on genomic profiling of hematologic malignancies, surgical treatment of gastrointestinal and hepatobiliary cancers and development and evaluation of novel molecular imaging technologies. Most of Dr. Gönen’s methodological research originates from these collaborations, including building, assessing and comparing prognostic and predictive models, design and analysis of clinical trials and imaging studies, as well as Bayesian methods. He is a recent awardee of the Foundation for NIH to study alternative response metrics in cancer clinical trials and the author of a book on the use of receiver operating characteristic curves using SAS®. Dr. Gönen served a co-director of the AACR/ASCO Vail Workshop on Methods in Clinical Cancer Research from 2011 to 2013 and was a member of ASCO’s Cancer Research Committee from 2012 to 2014. He has been serving the Society for Clinical Trials in various roles: Program Chair for the 2012 Annual Meeting, deputy editor of Clinical Trials: Journal of the Society for Clinical Trials, member of the board of directors and member of the executive committee. Dr. Gönen is a fellow of the American Statistical Association (ASA) and is an associate editor of Statistics in Biopharmaceutical Research, an ASA journal. He served the International Biometric Society as the Program Chair for its North America meeting in 2015.


Selected peer-reviewed publications:

  1. Kimmelman J, Carlisle B, Gönen M. Drug Development at the Portfolio Level Is Important for Policy, Care Decisions and Human Protections. JAMA. 2017 Sep 19;318(11):1003-1004. doi: 10.1001/jama.2017.11502. PubMed PMID: 28837722.

  2. Cunanan KM, Iasonos A, Shen R, Begg CB, Gönen M. An efficient basket trial design. Stat Med. 2017 May 10;36(10):1568-1579. doi: 10.1002/sim.7227. Epub 2017  Jan 18. PubMed PMID: 28098411; PubMed Central PMCID: PMC5380524.

  3. Heller G, Seshan VE, Moskowitz CS, Gönen M. Inference for the difference in the area under the ROC curve derived from nested binary regression models. Biostatistics. 2017 Apr 1;18(2):260-274. doi: 10.1093/biostatistics/kxw045. PubMed PMID: 27655817.

  4. Cunanan KM, Gonen M, Shen R, Hyman DM, Riely GJ, Begg CB, Iasonos A. Basket Trials in Oncology: A Trade-Off Between Complexity and Efficiency. J Clin Oncol.  2017 Jan 20;35(3):271-273. doi: 10.1200/JCO.2016.69.9751. Epub 2016 Nov 28. PubMed PMID: 27893325; PubMed Central PMCID: PMC5559900.

  5. Devlin SM, Ostrovnaya I, Gönen M. Boomerang: A method for recursive reclassification. Biometrics. 2016 Sep;72(3):995-1002. doi: 10.1111/biom.12469. Epub 2016 Jan 11. PubMed PMID: 26754051; PubMed Central PMCID: PMC4940305.

Visit PubMed for a full listing of Mithat Gönen’s journal articles

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