Mithat Gönen, PhD

Chief, Biostatistics Service

Mithat Gönen, PhD

Chief, Biostatistics Service

Pictured: Mithat Gönen

Office Phone

646-888-8238

E-mail

gonenm@mskcc.org

Dr. Gönen’s translational and clinical collaborations focus on genomic profiling of hematologic malignancies, surgical treatment of gastrointestinal and hepatobiliary cancers and development and evaluation of novel molecular imaging technologies. Most of Dr Gönen’s methodological research originates from these collaborations, including building, assessing and comparing prognostic and predictive models; design and analysis of clinical trials and imaging studies; as well as Bayesian methods. He is the principal investigator of a 2012 Geoffrey Beene Grant Award on Integrated Genetic Profiling to Predict Response to Therapy in Acute Myeloid Leukemia. He is the author of a book on the use of receiver operating characteristic (ROC) curves using SAS®

Dr. Gönen was a co-director of the AACR/ASCO Vail Workshop on Methods in Clinical Cancer Research from 2011 to 2013 and a member of ASCO’s Cancer Research Committee from 2012 to 2014. He has been serving the Society for Clinical Trials in various roles: Program Chair for the 2012 Annual Meeting, deputy editor of Clinical Trials: Journal of the Society for Clinical Trials and member of the board of directors. Dr. Gönen is a fellow the American Statistical Association and is an associate editor of Statistics in Biopharmaceutical Research, an ASA journal. He will serve as the Program Chair for ENAR’s 2015 Spring Meeting.

Education

Texas Tech University

Publications

Gönen M. Optimal Bayesian Enrichment: A View from the Closet. Biometrics (invited discussion). 2011, Early view (June 2011).

Haeno H*, Gönen M*, Davis MB, Herman JM, Iacobuzio-Donahue CA, Michor F. Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies. Cell. 2012, 148:362-75 (*: equal contribution)

Patil JP*, Gönen M*, Figueora ME, Fernandez H et al. Prognostic and Therapeutic Relevance of Integrated Genetic Profiling in Acute Myeloid Leukemia. New England Journal of Medicine, 2012 (*: equal contribution)

Gönen M. Visualizing Longitudinal Data with Dropouts. The American Statistician, May 2013.

Gönen M. Mixtures of Receiver Operating Characteristic Curves. Academic Radiology, August 2013 (Metz Memorial Issue).

Read more

  1. Westfall PH and Gönen M. Asymptotic properties of ANOVA Bayes factors. Communications in Statistics - Theory and Methods. 1996. 25(12): p. 3101-3123.

  2. Gönen M. A Bayesian analysis of the intraclass correlations in the mixed linear model. Communications in Statistics - Theory and Methods. 2000. 29(7): p. 1451-1464.

  3. Gönen M, Puri ML, Ruymgaart FH, and Van Zuijlen MCA. The limiting density of unit root test statistics: A unifying technique. Journal of Time Series Analysis. 2000. 21(3): p. 249-260.

  4. Motwani M, Jung C, Sirotnak FM, She Y, Shah MA, Gönen M, and Schwartz GK. Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts. Clinical Cancer Research. 2001. 7(12): p. 4209-4219.

  5. Kemeny NE, Gönen M, Sullivan D, Schwartz L, Benedetti F, Saltz L, Stockman J, Fong Y, Jarnagin W, Bertino J, Tong W, and Paty P. Phase I study of hepatic arterial infusion of floxuridine and dexamethasone with systemic irinotecan for unresectable hepatic metastases from colorectal cancer. Journal of Clinical Oncology. 2001. 19(10): p. 2687-2695.

  6. Yeung HWD, Cody Iii HS, Turlakow A, Riedel ER, Fey J, Gönen M, Nuñez R, Yeh SD, and Larson SM. Lymphosintigraphy and sentinel node localization in breast cancer patients: A comparison between 1-day and 2-day protocols. Journal of Nuclear Medicine. 2001. 42(3): p. 420-423.

  7. Abraham MT, Gönen M, and Kraus DH. Complications of type I thyroplasty and arytenoid adduction. Laryngoscope. 2001. 111(8): p. 1322-1329.

  8. Turlakow A, Larson SM, Coakley F, Akhurst T, Gönen M, Macapinlac HA, Kelly W, Leibel S, Humm J, Scardino P, Scher H, and Hricak H. Local detection of prostate cancer by positron emission tomography with 2-fluorodeoxyglucose: Comparison of filtered back projection and iterative reconstruction with segmented attenuation correction. Quarterly Journal of Nuclear Medicine. 2001. 45(3): p. 235-244.

  9. Gönen M, Panageas KS, and Larson SM. Statistical issues in analysis of diagnostic imaging experiments with multiple observations per patient. Radiology. 2001. 221(3): p. 763-767.

  10. Ramos CD, Erdi YE, Gönen M, Riedel E, Yeung HWD, Macapinlac HA, Chisin R, and Larson SM. FDG-PET standardized uptake values in normal anatomical structures using iterative reconstruction segmented attenuation correction and filtered back-projection. European Journal of Nuclear Medicine. 2001. 28(2): p. 155-164.

  11. Jarnagin WR, Fong Y, DeMatteo RP, Gönen M, Burke EC, Bodniewicz J, Youssef M, Klimstra D, and Blumgart LH. Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Annals of Surgery. 2001. 234(4): p. 507-519.

  12. Allen PJ, Stojadinovic A, Ben-Porat L, Gönen M, Kooby D, Blumgart L, Paty P, and Fong Y. The management of variant arterial anatomy during hepatic arterial infusion pump placement. Annals of Surgical Oncology. 2002. 9(9): p. 875-880.

  13. Nuñez R, Macapinlac HA, Yeung HWD, Akhurst T, Cai S, Osman I, Gönen M, Riedel E, Scher HI, and Larson SM. Combined 18F-FDG and 11C-methionine PET scans in patients with newly progressive metastatic prostate cancer. Journal of Nuclear Medicine. 2002. 43(1): p. 46-55.

  14. Etchebehere ECSC, Macapinlac HA, Gönen M, Humm J, Yeung HWD, Akhurst T, Scher HI, and Larson SM. Qualitative and quantitative comparison between images obtained with filtered back projection and iterative reconstruction in prostate cancer lesions on 18F-FDG PET. Quarterly Journal of Nuclear Medicine. 2002. 46(2): p. 122-130.

  15. Ross PL, Gerigk C, Gönen M, Yossepowitch O, Cagiannos I, Sogani PC, Scardino PT, and Kattan MW. Comparisons of nomograms and urologists’ predictions in prostate cancer. Seminars in Urologic Oncology. 2002. 20(2): p. 82-88.

  16. Akhurst T, Downey RJ, Ginsberg MS, Gönen M, Bains M, Korst R, Ginsberg RJ, Rusch VW, and Larson SM. An initial experience with FDG-PET in the imaging of residual disease after induction therapy for lung cancer. Annals of Thoracic Surgery. 2002. 73(1): p. 259-266.

  17. Panageas KS, Smith A, Gönen M, and Chapman PB. An optimal two-stage phase II design utilizing complete and partial response information separately. Controlled Clinical Trials. 2002. 23(4): p. 367-379.

  18. Stanziale SF, Petrowsky H, Joe JK, Roberts GD, Zager JS, Gusani NJ, Ben-Porat L, Gönen M, and Fong Y. Ionizing radiation potentiates the antitumor efficacy of oncolytic herpes simplex virus G207 by upregulating ribonucleotide reductase. Surgery. 2002. 132(2): p. 353-359.

  19. Kemeny N, Tong W, Gönen M, Stockman J, Di Lauro C, Teitcher J, White P, Price C, Saltz L, Sharma S, and Graham MA. Phase I study of weekly oxaliplatin plus irinotecan in previously treated patients with metastatic colorectal cancer. Annals of Oncology. 2002. 13(9): p. 1490-1496.

  20. Petrowsky H, Gönen M, Jarnagin W, Lorenz M, DeMatteo R, Heinrich S, Encke A, Blumgart L, and Fong Y. Second liver resections are safe and effective treatment for recurrent hepatic metastases from colorectal cancer: A Bi-institutional analysis. Annals of Surgery. 2002. 235(6): p. 863-871.

  21. Jarnagin WR, Gönen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, Corvera C, Weber S, Blumgart LH, and Nagorney DM. Improvement in perioperative outcome after hepatic resection: Analysis of 1,803 consecutive cases over the past decade. Annals of Surgery. 2002. 236(4): p. 397-407.

  22. Holen KD, Klimstra DS, Hummer A, Gönen M, Conlon K, Brennan M, and Saltz LB. Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors. Journal of Clinical Oncology. 2002. 20(24): p. 4673-4678.

  23. Wong RJ, Lin DT, Schöder H, Patel SG, Gönen M, Wolden S, Pfister DG, Shah JP, Larson SM, and Kraus DH. Diagnostic and prognostic value of [18F]fluorodeoxyglucose positron emission tomography for recurrent head and neck squamous cell carcinoma. Journal of Clinical Oncology. 2002. 20(20): p. 4199-4208.

  24. Jung C, Motwani M, Kortmansky J, Sirotnak FM, She Y, Gönen M, Haimovitz-Friedman A, and Schwartz GK. The Cyclin-Dependent Kinase Inhibitor Flavopiridol Potentiates γ-Irradiation-Induced Apoptosis in Colon and Gastric Cancer Cells. Clinical Cancer Research. 2003. 9(16 I): p. 6052-6061.

  25. Yeung HWD, Grewal RK, Gönen M, Schöder H, and Larson SM. Patterns of 18F-FDG uptake in adipose tissue and muscle: A potential source of false-positives for PET. Journal of Nuclear Medicine. 2003. 44(11): p. 1789-1796.

  26. Hann LE, Kim CM, Gönen M, Barakat R, Choi PH, and Bach AM. Sonohysterography Compared With Endometrial Biopsy for Evaluation of the Endometrium in Tamoxifen-Treated Women. Journal of Ultrasound in Medicine. 2003. 22(11): p. 1173-1179.

  27. Pandit N, Gönen M, Krug L, and Larson SM. Prognostic value of [ 18F]FDG-PET imaging in small cell lung cancer. European Journal of Nuclear Medicine and Molecular Imaging. 2003. 30(1): p. 78-84.

  28. Kooby DA, Fong Y, Suriawinata A, Gönen M, Allen PJ, Klimstra DS, DeMatteo RP, D’Angelica M, Blumgart LH, and Jarnagin WR. Impact of steatosis on perioperative outcome following hepatic resection. Journal of Gastrointestinal Surgery. 2003. 7(8): p. 1034-1044.

  29. Flores RM, Akhurst T, Gönen M, Larson SM, Rusch VW, Sugarbaker DJ, Miller D, Smythe WR, and Vallieres E. Positron emission tomography defines metastatic disease but not locoregional disease in patients with malignant pleural mesothelioma. Journal of Thoracic and Cardiovascular Surgery. 2003. 126(1): p. 11-16.

  30. Gönen M. Planning for subgroup analysis: A case study of treatment-marker interaction in metastatic colorectal cancer. Controlled Clinical Trials. 2003. 24(4): p. 355-363.

  31. Shoup M, Gönen M, D’Angelica M, Jarnagin WR, DeMatteo RP, Schwartz LH, Tuorto S, Blumgart LH, Fong Y, Aranha GV, Tsiotos GG, Sauvanet A, Deshpande R, and Young-Fadok TM. Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection. Journal of Gastrointestinal Surgery. 2003. 7(3): p. 325-330.

  32. Lopez-Corona E, Ohori M, Scardino PT, Reuter VE, Gönen M, and Kattan MW. A nomogram for predicting a positive repeat prostate biopsy in patients with a previous negative biopsy session. Journal of Urology. 2003. 170(4 I): p. 1184-1188.

  33. Eastham JA, Kattan MW, Riedel E, Begg CB, Wheeler TM, Gerigk C, Gönen M, Reuter V, and Scardino PT. Variations among individual surgeons in the rate of positive surgical margins in radical prostatectomy specimens. Journal of Urology. 2003. 170(6 I): p. 2292-2295.

  34. Kooby DA, Stockman J, Ben-Porat L, Gönen M, Jarnagin WR, Dematteo RP, Tuorto S, Wuest D, Blumgart LH, Fong Y, Bolton JS, Choti MA, Clary B, Baisden CE, and Fong Y. Influence of Transfusions on Perioperative and Long-Term Outcome in Patients Following Hepatic Resection for Colorectal Metastases. Annals of Surgery. 2003. 237(6): p. 860-870.

  35. Gönen M, Westfall PH, and Johnson WO. Bayesian multiple testing for two-sample multivariate endpoints. Biometrics. 2003. 59(1): p. 76-82.

  36. Ilson DH, Bains M, Kelsen DP, O’Reilly E, Karpeh M, Coit D, Rusch V, Gönen M, Wilson K, and Minsky BD. Phase I trial of escalating-dose irinotecan given weekly with cisplatin and concurrent radiotherapy in locally advanced esophageal cancer. Journal of Clinical Oncology. 2003. 21(15): p. 2926-2932.

  37. Kemeny N, Jarnagin W, Gönen M, Stockman J, Blumgart L, Sperber D, Hummer A, and Fong Y. Phase I/II study of hepatic arterial therapy with floxuridine and dexamethasone in combination with intravenous irinotecan as adjuvant treatment after resection of hepatic metastases from colorectal cancer. Journal of Clinical Oncology. 2003. 21(17): p. 3303-3309.

  38. Downey RJ, Akhurst T, Ilson D, Ginsberg R, Bains MS, Gönen M, Koong H, Gollub M, Minsky BD, Zakowski M, Turnbull A, Larson SM, and Rusch V. Whole body 18FDG-PET and the response of esophageal cancer to induction therapy: Results of a prospective trial. Journal of Clinical Oncology. 2003. 21(3): p. 428-432.

  39. Gönen M, Hummer A, Zervoudakis A, Sullivan D, Fong Y, Banerjee D, Klimstra D, Cordon-Cardo C, Bertino J, and Kemeny N. Thymidylate synthase expression in hepatic tumors is a predictor of survival and progression in patients with resectable metastatic colorectal cancer. Journal of Clinical Oncology. 2003. 21(3): p. 406-412.

  40. Weitz J, D’Angelica M, Gönen M, Klimstra D, Coit DG, Brennan MF, and Karpeh MS. Interaction of splenectomy and perioperative blood transfusions on prognosis of patients with proximal gastric and gastroesophageal junction cancer. Journal of Clinical Oncology. 2003. 21(24): p. 4597-4603.

  41. D’Angelica M, Fong Y, Weber S, Gönen M, DeMatteo RP, Conlon K, Blumgart LH, and Jarnagin WR. The role of staging laparoscopy in hepatobiliary malignancy: Prospective analysis of 401 cases. Annals of Surgical Oncology. 2003. 10(2): p. 183-189.

  42. Pandit-Taskar N, Schöder H, Gönen M, Larson SM, and Yeung HWD. Clinical significance of unexplained abnormal focal FDG uptake in the abdomen during whole-body PET. American Journal of Roentgenology. 2004. 183(4): p. 1143-1147.

  43. Brenner B, Shah MA, Gönen M, Klimstra DS, Shia J, and Kelsen DP. Small-cell carcinoma of the gastrointestinal tract: A retrospective study of 64 cases. British Journal of Cancer. 2004. 90(9): p. 1720-1726.

  44. Schöder H, Erdi YE, Chao K, Gönen M, Larson SM, and Yeung HWD. Clinical implications of different image reconstruction parameters for interpretation of whole-body PET studies in cancer patients. Journal of Nuclear Medicine. 2004. 45(4): p. 559-566.

  45. Hricak H, Wang L, Wei DC, Coakley FV, Akin O, Reuter VE, Gönen M, Kattan MW, Onyebuchi CN, and Scardino PT. The role of preoperative endorectal magnetic resonance imaging in the decision regarding whether to preserve or resect neurovascular bundles during radical retropubic prostatectomy. Cancer. 2004. 100(12): p. 2655-2663.

  46. Carlo WF, Hummer AJ, Schwartz L, Sullivan D, Gönen M, Jarnagin W, Fong Y, and Kemeny N. Extent of hepatic resection does not correlate with toxicity following adjuvant chemotherapy. Journal of Surgical Oncology. 2004. 87(2): p. 85-90.

  47. Gönen M. Sample size and power for McNemar’s test with clustered data. Statistics in Medicine. 2004. 23(14): p. 2283-2294.

  48. Weitz J, D’Angelica M, Jarnagin W, Gönen M, Fong Y, Blumgart L, and DeMatteo R. Selective use of diagnostic laparoscopy prior to planned hepatectomy for patients with hepatocellular carcinoma. Surgery. 2004. 135(3): p. 273-281.

  49. D’Angelica M, Gönen M, Brennan MF, Turnbull AD, Bains M, and Karpeh MS. Patterns of initial recurrence in completely resected gastric adenocarcinoma. Annals of Surgery. 2004. 240(5): p. 808-816.

  50. Schöder H, Yeung HWD, Gönen M, Kraus D, and Larson SM. Head and Neck Cancer: Clinical Usefulness and Accuracy of PET/CT Image Fusion. Radiology. 2004. 231(1): p. 65-72.

  51. Antonescu CR, Viale A, Sarran L, Tschernyavsky SJ, Gönen M, Segal NH, Maki RG, Socci ND, DeMatteo RP, and Besmer P. Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site. Clinical Cancer Research. 2004. 10(10): p. 3282-3290.

  52. Stanziale SF, Petrowsky H, Adusumilli PS, Ben-Porat L, Gönen M, and Fong Y. Infection with Oncolytic Herpes Simplex Virus-1 Induces Apoptosis in Neighboring Human Cancer Cells: A Potential Target to Increase Anticancer Activity. Clinical Cancer Research. 2004. 10(9): p. 3225-3232.

  53. Brenner B, Ilson DH, Minsky BD, Bains MS, Tong W, Gönen M, and Kelsen DP. Phase I trial of combined-modality therapy for localized esophageal cancer: Escalating doses of continuous-infusion paclitaxel with cisplatin and concurrent radiation therapy. Journal of Clinical Oncology. 2004. 22(1): p. 45-52.

  54. Downey RJ, Akhurst T, Gönen M, Vincent A, Bains MS, Larson S, and Rusch V. Preoperative F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value predicts survival after lung cancer resection. Journal of Clinical Oncology. 2004. 22(16): p. 3255-3260.

  55. Vural B, Chen LC, Saip P, Chen YT, Ustuner Z, Gönen M, Simpson AJG, Old LJ, Ozbek U, and Gure AO. Frequency of SOX group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish patients with small cell lung carcinoma and their correlation with clinical parameters. Cancer. 2005. 103(12): p. 2575-2583.

  56. Liau KH, Ruo L, Shia J, Padela A, Gönen M, Jarnagin WR, Fong Y, D’Angelica MI, Blumgart LH, and DeMatteo RP. Outcome of partial hepatectomy for large (> 10 cm) hepatocellular carcinoma. Cancer. 2005. 104(9): p. 1948-1955.

  57. Kemeny N, Eid A, Stockman J, Gönen M, Schwartz L, Tetzlaff E, and Paty P. Hepatic arterial infusion of Floxuridine and dexamethasone plus high-dose Mitomycin C for patients with unresectable hepatic metastases from colorectal carcinoma. Journal of Surgical Oncology. 2005. 91(2): p. 97-101.

  58. Gönen M. Planning a dose-response study with subject-specific doses. Statistics in Medicine. 2005. 24(17): p. 2613-2623.

  59. Yeung HWD, Schöder H, Smith A, Gönen M, and Larson SM. Clinical value of combined positron emission tomography/computed tomography imaging in the interpretation of 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography studies in cancer patients. Molecular Imaging and Biology. 2005. 7(3): p. 229-235.

  60. Gönen M. A Bayesian evaluation of enrolling additional patients at the maximum tolerated dose in Phase I trials. Contemporary Clinical Trials. 2005. 26(2): p. 131-140.

  61. Hawkins WG, DeMatteo RP, Cohen MS, Jarnagin WR, Fong Y, D’Angelica M, Gönen M, and Blumgart LH. Caudate hepatectomy for cancer: A single institution experience with 150 patients. Journal of the American College of Surgeons. 2005. 200(3): p. 345-352.

  62. Bennett JJ, Gönen M, D’Angelica M, Jaques DP, Brennan MF, and Coit DG. Is detection of asymptomatic recurrence after curative resection associated with improved survival in patients with gastric cancer? Journal of the American College of Surgeons. 2005. 201(4): p. 503-510.

  63. Kemeny NE and Gönen M. Hepatic arterial infusion after liver resection [7]. New England Journal of Medicine. 2005. 352(7): p. 734-735.

  64. Gönen M and Heller G. Concordance probability and discriminatory power in proportional hazards regression. Biometrika. 2005. 92(4): p. 965-970.

  65. Yanke BV, Gönen M, Scardino PT, and Kattan MW. Validation of a nomogram for predicting positive repeat biopsy for prostate cancer. Journal of Urology. 2005. 173(2): p. 421-424.

  66. Kraus DH, Gönen M, Mener D, Brown AE, Bilsky MH, and Shah JP. A standardized regimen of antibiotics prevents infectious complications in skull base surgery. Laryngoscope. 2005. 115(8): p. 1347-1357.

  67. Spanknebel K, Coit DG, Bieligk SC, Gönen M, Rosai J, and Klimstra DS. Characterization of micrometastatic disease in melanoma sentinel lymph nodes by enhanced pathology: Recommendations for standardizing pathologic analysis. American Journal of Surgical Pathology. 2005. 29(3): p. 305-317.

  68. Howard MA, Cordeiro PG, Disa J, Samson W, Gönen M, Schoelle RN, and Mehrara B. Free tissue transfer in the elderly: Incidence of perioperative complications following microsurgical reconstruction of 197 septuagenarians and octogenarians. Plastic and Reconstructive Surgery. 2005. 116(6): p. 1659-1668.

  69. Maluccio M, Covey AM, Gandhi R, Gönen M, Getrajdman GI, Brody LA, Fong Y, Jarnagin W, D’Angelica M, Blumgart L, Dematteo R, and Brown KT. Comparison of survival rates after bland arterial embolization and ablation versus surgical resection for treating solitary hepatocellular carcinoma up to 7 cm. Journal of Vascular and Interventional Radiology. 2005. 16(7): p. 955-961.

  70. Fong Y, Gönen M, Rubin D, Radzyner M, Brennan MF, Nagorney DM, Warshaw AL, Jeekel JH, Cameron JL, Polk Jr HC, Munoz E, Roberts JP, and Lewis FR. Long-term survival is superior after resection for cancer in high-volume centers. Annals of Surgery. 2005. 242(4): p. 540-547.

  71. Shah MA, Kemeny N, Hummer A, Drobnjak M, Motwani M, Cordon-Cardo C, Gönen M, and Schwartz GK. Drg1 expression in 131 colorectal liver metastases: Correlation with clinical variables and patient outcomes. Clinical Cancer Research. 2005. 11(9): p. 3296-3302.

  72. Shah MA, Kortmansky J, Motwani M, Drobnjak M, Gönen M, Yi S, Weyerbacher A, Cordon-Cardo C, Lefkowitz R, Brenner B, O’Reilly E, Saltz L, Tong W, Kelsen DP, and Schwartz GK. A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol. Clinical Cancer Research. 2005. 11(10): p. 3836-3845.

  73. Schöder H, Herrmann K, Gönen M, Hricak H, Eberhard S, Scardino P, Scher HI, and Larson SM. 2-[ 18F]fluoro-2-deoxyglucose positron emission tomography for the detection of disease in patients with prostate-specific antigen relapse after radical prostatectomy. Clinical Cancer Research. 2005. 11(13): p. 4761-4769.

  74. Gure AO, Chua R, Williamson B, Gönen M, Ferrera CA, Gnjatic S, Ritter G, Simpson AJG, Chen YT, Old LJ, and Altorki NK. Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer. Clinical Cancer Research. 2005. 11(22): p. 8055-8062.

  75. Gönen M, Johnson WO, Lu Y, and Westfall PH. The Bayesian two-sample t test. American Statistician. 2005. 59(3): p. 252-257.

  76. Kortmansky J, Shah MA, Kaubisch A, Weyerbacher A, Yi S, Tong W, Sowers R, Gönen M, O’Reilly E, Kemeny N, Ilson DI, Saltz LB, Maki RG, Kelsen DP, and Schwartz GK. Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with fluorouracil in patients with advanced solid tumors. Journal of Clinical Oncology. 2005. 23(9): p. 1875-1884.

  77. Kemeny N, Jarnagin W, Paty P, Gönen M, Schwartz L, Morse M, Leonard G, D’Angelica M, DeMatteo R, Blumgart L, and Fong Y. Phase I trial of systemic oxaliplatin combination chemotherapy with hepatic arterial infusion in patients with unresectable liver metastases from colorectal cancer. Journal of Clinical Oncology. 2005. 23(22): p. 4888-4896.

  78. Schöder H, Noy A, Gönen M, Weng L, Green D, Erdi YE, Larson SM, and Yeung HWD. Intensity of 18fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin’s lymphoma. Journal of Clinical Oncology. 2005. 23(21): p. 4643-4651.

  79. Specht MC, Kattan MW, Gönen M, Fey J, and Van Zee KJ. Predicting nonsentinel node status after positive sentinel lymph biopsy for breast cancer: Clinicians versus nomogram. Annals of Surgical Oncology. 2005. 12(8): p. 654-659.

  80. Stiles BM, Adusumilli PS, Stanziale SF, Eisenberg DP, Bhargava A, Kim TH, Chan MK, Huq R, Gönen M, and Fong Y. Estrogen enhances the efficacy of an oncolytic HSV-1 mutant in the treatment of estrogen receptor-positive breast cancer. International Journal of Oncology. 2006. 28(6): p. 1429-1439.

  81. Schöder H, Carlson DL, Kraus DH, Stambuk HE, Gönen M, Erdi YE, Yeung HWD, Huvos AG, Shah JP, Larson SM, and Wong RJ. 18F-FDG PET/CT for detecting nodal metastases in patients with oral cancer staged N0 by clinical examination and CT/MRI. Journal of Nuclear Medicine. 2006. 47(5): p. 755-762.

  82. Pryma DA, Schöder H, Gönen M, Robbins RJ, Larson SM, and Yeung HWD. Diagnostic accuracy and prognostic value of 18F-FDG PET in Hürthle cell thyroid cancer patients. Journal of Nuclear Medicine. 2006. 47(8): p. 1260-1266.

  83. Santiago JFY, Gönen M, Yeung H, Macapinlac H, and Larson S. A retrospective analysis of the impact of 18F-FDG PET scans on clinical management of 133 breast cancer patients. Quarterly Journal of Nuclear Medicine and Molecular Imaging. 2006. 50(1): p. 61-67.

  84. D’Angelica M, Maddineni S, Fong Y, Martin RCG, Cohen MS, Ben-Porat L, Gönen M, DeMatteo RP, Blumgart LH, and Jarnagin WR. Optimal abdominal incision for partial hepatectomy: Increased late complications with Mercedes-type incisions compared to extended right subcostal incisions. World Journal of Surgery. 2006. 30(3): p. 410-418.

  85. Mullerad M, Eisenberg DP, Akhurst TJ, Adusumilli PS, Riedl CC, Bhargava A, Gönen M, Finn R, Scardino PT, and Fong Y. Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus. Molecular Imaging and Biology. 2006. 8(1): p. 30-35.

  86. Rizk N, Downey RJ, Akhurst T, Gönen M, Bains MS, Larson S, and Rusch V. Preoperative 18[F]-fluorodeoxyglucose positron emission tomography standardized uptake values predict survival after esophageal adenocarcinoma resection. Annals of Thoracic Surgery. 2006. 81(3): p. 1076-1081.

  87. Flores RM, Akhurst T, Gönen M, Zakowski M, Dycoco J, Larson SM, and Rusch VW. Positron emission tomography predicts survival in malignant pleural mesothelioma. Journal of Thoracic and Cardiovascular Surgery. 2006. 132(4): p. 763-768.

  88. Are C, Gönen M, D’Angelica M, DeMatteo RP, Fong Y, Blumgart LH, and Jarnagin WR. Differential diagnosis of proximal biliary obstruction. Surgery. 2006. 140(5): p. 756-763.

  89. Jarnagin WR, Zager JS, Hezel M, Stanziale SF, Adusumilli PS, Gönen M, Ebright MI, Culliford A, Gusani NJ, and Fong Y. Treatment of cholangiocarcinoma with oncolytic herpes simplex virus combined with external beam radiation therapy. Cancer Gene Therapy. 2006. 13(3): p. 326-334.

  90. Budak-Alpdogan T, Przybylowski M, Gönen M, Sadelain M, Bertino J, and Rivière I. Functional assessment of the engraftment potential of gammaretrovirus- modified CD34 + cells, using a short serum-free transduction protocol. Human Gene Therapy. 2006. 17(7): p. 780-794.

  91. Brenner B, Shah MA, Karpeh MS, Gönen M, Brennan MF, Coit DG, Klimstra DS, Tang LH, and Kelsen DP. A phase II trial of neoadjuvant cisplatin-fluorouracil followed by postoperative intraperitoneal floxuridine-leucovorin in patients with locally advanced gastric cancer. Annals of Oncology. 2006. 17(9): p. 1404-1411.

  92. Grobmyer SR, Wang L, Gönen M, Fong Y, Klimstra D, D’Angelica M, DeMatteo RP, Schwartz L, Blumgart LH, and Jarnagin WR. Perihepatic lymph node assessment in patients undergoing partial hepatectomy for malignancy. Annals of Surgery. 2006. 244(2): p. 260-264.

  93. Fong Y, Wagman L, Gönen M, Crawford J, Reed W, Swanson R, Pan C, Ritchey J, Stewart A, and Choti M. Evidence-based gallbladder cancer staging: Changing cancer staging by analysis of data from the national cancer database. Annals of Surgery. 2006. 243(6): p. 767-771.

  94. Allen PJ, D’Angelica M, Gönen M, Jaques DP, Coit DG, Jarnagin WR, DeMatteo R, Fong Y, Blumgart LH, and Brennan MF. A selective approach to the resection of cystic lesions of the pancreas: Results from 539 consecutive patients. Annals of Surgery. 2006. 244(4): p. 572-579.

  95. Gerecitano J, Goy A, Wright J, MacGregor-Cortelli B, Neylon E, Gönen M, Esseltine D, Boral A, Schenkein D, Busam K, Teruya-Feldstein J, Sachs D, and O’Connor OA. Drug-induced cutaneous vasculitis in patients with non-Hodgkin lymphoma treated with the novel proteasome inhibitor bortezomib: A possible surrogate marker of response? British Journal of Haematology. 2006. 134(4): p. 391-398.

  96. Toner LE, Vrhovac R, Smith EA, Gardner J, Heaney M, Gönen M, Teruya-Feldstein J, Sirotnak F, and O’Connor OA. The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-hodgkin’s lymphoma. Clinical Cancer Research. 2006. 12(3 I): p. 924-932.

  97. Jarnagin WR, Klimstra DS, Hezel M, Gönen M, Fong Y, Roggin K, Cymes K, Dematteo RP, D’Angelica M, Blumgart LH, and Singh B. Differential cell cycle-regulatory protein expression in biliary tract adenocarcinoma: Correlation with anatomic site, pathologic variables, and clinical outcome. Journal of Clinical Oncology. 2006. 24(7): p. 1152-1160.

  98. Robbins RJ, Wan Q, Grewal RK, Reibke R, Gönen M, Strauss HW, Tuttle RM, Drucker W, and Larson SM. Real-time prognosis for metastatic thyroid carcinoma based on 2-[ 18F]fluoro-2-deoxy-D-glucose-positron emission tomography scanning. Journal of Clinical Endocrinology and Metabolism. 2006. 91(2): p. 498-505.

  99. Brady MS, Akhurst T, Spanknebel K, Hilton S, Gönen M, Patel A, and Larson S. Utility of preoperative [(18)]F Fluorodeoxyglucose-positron emission tomography scanning in high-risk melanoma patients. Annals of Surgical Oncology. 2006. 13(4): p. 525-532.

  100. Port ER, Yeung H, Gönen M, Liberman L, Caravelli J, Borgen P, and Larson S. 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography scanning affects surgical management in selected patients with high-risk, operable breast carcinoma. Annals of Surgical Oncology. 2006. 13(5): p. 677-684.

  101. Yoon SS, Kim SH, Gönen M, Heffernan NM, Detwiller KY, Jarnagin WR, D’Angelica M, Blumgart LH, Tanabe KK, and DeMatteo RP. Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases. Annals of Surgical Oncology. 2006. 13(3): p. 353-362.

  102. Schöder H and Gönen M. Screening for cancer with PET and PET/CT: Potential and limitations. Journal of Nuclear Medicine. 2007. 48(1 SUPPL.): p. 4S-18S.

  103. Yeh JJ, Gönen M, Tomlinson JS, Idrees K, Brennan MF, and Fong Y. Effect of blood transfusion on outcome after pancreaticoduodenectomy for exocrine tumour of the pancreas. British Journal of Surgery. 2007. 94(4): p. 466-472.

  104. Park JO, Gönen M, D’Angelica MI, Dematteo RP, Fong Y, Wuest D, Blumgart LH, and Jarnagin WR. Autologous versus allogeneic transfusions: No difference in perioperative outcome after partial hepatectomy: Autologous transfusion on hepatectomy outcome. Journal of Gastrointestinal Surgery. 2007. 11(10): p. 1286-1293.

  105. House MG, Gönen M, Jarnagin WR, D’Angelica M, Dematteo RP, Fong Y, Brennan MF, and Allen PJ. Prognostic significance of pathologic nodal status in patients with resected pancreatic cancer. Journal of Gastrointestinal Surgery. 2007. 11(11): p. 1549-1555.

  106. Dalal KM, Woo Y, Galanis C, Gönen M, Tang L, Allen P, Dematteo R, Fong Y, and Coit DG. Detection of micrometastases in peritoneal washings of pancreatic cancer patients by the reverse transcriptase polymerase chain reaction. Journal of Gastrointestinal Surgery. 2007. 11(12): p. 1598-1606.

  107. Parks R, Gönen M, Kemeny N, Jarnagin W, D’Angelica M, DeMatteo R, Garden OJ, Blumgart LH, and Fong Y. Adjuvant Chemotherapy Improves Survival after Resection of Hepatic Colorectal Metastases: Analysis of Data from Two Continents. Journal of the American College of Surgeons. 2007. 204(5): p. 753-761.

  108. Miller G, Biernacki P, Kemeny NE, Gönen M, Downey R, Jarnagin WR, D’Angelica M, Fong Y, Blumgart LH, and DeMatteo RP. Outcomes after Resection of Synchronous or Metachronous Hepatic and Pulmonary Colorectal Metastases. Journal of the American College of Surgeons. 2007. 205(2): p. 231-238.

  109. Downey RJ, Akhurst T, Gönen M, Park B, and Rusch V. Fluorine-18 fluorodeoxyglucose positron emission tomographic maximal standardized uptake value predicts survival independent of clinical but not pathologic TNM staging of resected non-small cell lung cancer. Journal of Thoracic and Cardiovascular Surgery. 2007. 133(6): p. 1419-1427.e4.

  110. Divgi CR, Pandit-Taskar N, Jungbluth AA, Reuter VE, Gönen M, Ruan S, Pierre C, Nagel A, Pryma DA, Humm J, Larson SM, Old LJ, and Russo P. Preoperative characterisation of clear-cell renal carcinoma using iodine-124-labelled antibody chimeric G250 ( 124I-cG250) and PET in patients with renal masses: a phase I trial. Lancet Oncology. 2007. 8(4): p. 304-310.

  111. Lassmann S, Tang L, Capanu M, Brabletz T, Schöpflin A, Zur Hausen A, Gönen M, Kemeny N, Shia J, Klimstra D, and Werner M. Predictive Molecular Markers for Colorectal Cancer Patients With Resected Liver Metastasis and Adjuvant Chemotherapy. Gastroenterology. 2007. 133(6): p. 1831-1839.

  112. DeMatteo RP, Maki RG, Singer S, Gönen M, Brennan MF, and Antonescu CR. Results of tyrosine kinase inhibitor therapy followed by surgical resection for metastatic gastrointestinal stromal tumor. Annals of Surgery. 2007. 245(3): p. 347-352.

  113. Barbour AP, Rizk NP, Gönen M, Tang L, Bains MS, Rusch VW, Coit DG, and Brennan MF. Adenocarcinoma of the gastroesophageal junction: Influence of esophageal resection margin and operative approach on outcome. Annals of Surgery. 2007. 246(1): p. 1-8.

  114. Are C, Gönen M, Zazzali K, DeMatteo RP, Jarnagin WR, Fong Y, Blumgart LH, and D’Angelica M. The impact of margins on outcome after hepatic resection for colorectal metastasis. Annals of Surgery. 2007. 246(2): p. 295-300.

  115. Tomlinson JS, Jarnagin WR, DeMatteo RP, Fong Y, Kornprat P, Gönen M, Kemeny N, Brennan MF, Blumgart LH, and D’Angelica M. Actual 10-year survival after resection of colorectal liver metastases defines cure. Journal of Clinical Oncology. 2007. 25(29): p. 4575-4580.

  116. Saltz LB, Lenz HJ, Kindler HL, Hochster HS, Wadler S, Hoff PM, Kemeny NE, Hollywood EM, Gönen M, Quinones M, Morse M, and Chen HX. Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study. Journal of Clinical Oncology. 2007. 25(29): p. 4557-4561.

  117. Ferrone CR, Tang LH, Tomlinson J, Gönen M, Hochwald SN, Brennan MF, Klimstra DS, and Allen PJ. Determining prognosis in patients with pancreatic endocrine neoplasms: Can the WHO classification system be simplified? Journal of Clinical Oncology. 2007. 25(35): p. 5609-5615.

  118. Kornprat P, Jarnagin WR, Gönen M, DeMatteo RP, Fong Y, Blumgart LH, and D’Angelica M. Outcome after hepatectomy for multiple (four or more) colorectal metastases in the era of effective chemotherapy. Annals of Surgical Oncology. 2007. 14(3): p. 1151-1160.

  119. D’Angelica M, Kornprat P, Gönen M, Chung KY, Jarnagin WR, DeMatteo RP, Fong Y, Kemeny N, Blumgart LH, and Saltz LB. Lack of evidence for increased operative morbidity after hepatectomy with perioperative use of bevacizumab: A matched case-control study. Annals of Surgical Oncology. 2007. 14(2): p. 759-765.

  120. Barbour AP, Rizk NP, Gönen M, Tang L, Bains MS, Rusch VW, Coit DG, and Brennan MF. Lymphadenectomy for adenocarcinoma of the gastroesophageal junction (GEJ): Impact of adequate staging on outcome. Annals of Surgical Oncology. 2007. 14(2): p. 306-316.

  121. Gold JS, Van Der Zwan SM, Gönen M, Maki RG, Singer S, Brennan MF, Antonescu CR, and DeMatteo RP. Outcome of metastatic GIST in the era before tyrosine kinase inhibitors. Annals of Surgical Oncology. 2007. 14(1): p. 134-142.

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  123. Strong VE, D’Angelica M, Tang L, Prete F, Gönen M, Coit D, Touijer KA, Fong Y, and Brennan MF. Laparoscopic adrenalectomy for isolated adrenal metastasis. Annals of Surgical Oncology. 2007. 14(12): p. 3392-3400.

  124. Gold JS, Tang LH, Gönen M, Coit DG, Brennan MF, and Allen PJ. Utility of a prognostic nomogram designed for gastric cancer in predicting outcome of patients with R0 resected duodenal adenocarcinoma. Annals of Surgical Oncology. 2007. 14(11): p. 3159-3167.

  125. Mansour JC, Tang L, Shah M, Bentrem D, Klimstra DS, Gönen M, Kelsen DP, Brennan MF, and Coit DG. Does graded histologic response after neoadjuvant chemotherapy predict survival for completely resected gastric cancer? Annals of Surgical Oncology. 2007. 14(12): p. 3412-3418.

  126. Sofocleous CT, Nascimento RG, Gönen M, Theodoulou M, Covey AM, Brody LA, Solomon SM, Thornton R, Fong Y, Getrajdman GI, and Brown KT. Radiofrequency ablation in the management of liver metastases from breast cancer. American Journal of Roentgenology. 2007. 189(4): p. 883-889.

  127. Ong SC, Schöder H, Patel SG, Tabangay-Lim IM, Doddamane I, Gönen M, Shaha AR, Tuttle RM, Shah JP, and Larson SM. Diagnostic accuracy of 18F-FDG PET in restaging patients with medullary thyroid carcinoma and elevated calcitonin levels. Journal of Nuclear Medicine. 2007. 48(4): p. 501-507.

  128. DeMatteo RP, Gold JS, Saran L, Gönen M, Kui HL, Maki RG, Singer S, Besmer P, Brennan MF, and Antonescu CR. Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST). Cancer. 2008. 112(3): p. 608-615.

  129. Quah HM, Chou JF, Gönen M, Shia J, Schrag D, Saltz LB, Goodman KA, Minsky BD, Wong WD, and Weiser MR. Pathologic stage is most prognostic of disease-free survival in locally advanced rectal cancer patients after preoperative chemoradiation. Cancer. 2008. 113(1): p. 57-64.

  130. Ghosh P and Gönen M. Bayesian modeling of multivariate average bioequivalence. Statistics in Medicine. 2008. 27(13): p. 2402-2419.

  131. Dalal KM, Woo Y, Kelly K, Galanis C, Gönen M, Fong Y, and Coit DG. Detection of micrometastases in peritoneal washings of gastric cancer patients by the reverse transcriptase polymerase chain reaction. Gastric Cancer. 2008. 11(4): p. 206-213.

  132. Quah HM, Chou JF, Gönen M, Shia J, Schrag D, Landmann RG, Guillem JG, Paty PB, Temple LK, Wong WD, and Weiser MR. Identification of patients with high-risk stage II colon cancer for adjuvant therapy. Diseases of the Colon and Rectum. 2008. 51(5): p. 503-507.

  133. Ferrone CR, Brennan MF, Gönen M, Coit DG, Fong Y, Chung S, Tang L, Klimstra D, and Allen PJ. Pancreatic adenocarcinoma: The actual 5-year survivors. Journal of Gastrointestinal Surgery. 2008. 12(4): p. 701-706.

  134. House MG, Fong Y, Arnaoutakis DJ, Sharma R, Winston CB, Protic M, Gönen M, Olson SH, Kurtz RC, Brennan MF, and Allen PJ. Preoperative predictors for complications after pancreaticoduodenectomy: Impact of BMI and body fat distribution. Journal of Gastrointestinal Surgery. 2008. 12(2): p. 270-278.

  135. Vickers AJ, Bianco FJ, Gönen M, Cronin AM, Eastham JA, Schrag D, Klein EA, Reuther AM, Kattan MW, Pontes JE, and Scardino PT. Effects of Pathologic Stage on the Learning Curve for Radical Prostatectomy: Evidence That Recurrence in Organ-Confined Cancer Is Largely Related to Inadequate Surgical Technique. European Urology. 2008. 53(5): p. 960-966.

  136. Shia J, Klimstra DS, Nitzkorski JR, Low PS, Gönen M, Landmann R, Weiser MR, Franklin WA, Prendergast FG, Murphy L, Tang LH, Temple L, Guillem JG, Wong WD, and Paty PB. Immunohistochemical expression of folate receptor α in colorectal carcinoma: patterns and biological significance. Human Pathology. 2008. 39(4): p. 498-505.

  137. Cho CS, Gönen M, Shia J, Kattan MW, Klimstra DS, Jarnagin WR, D’Angelica MI, Blumgart LH, and DeMatteo RP. A Novel Prognostic Nomogram Is More Accurate than Conventional Staging Systems for Predicting Survival after Resection of Hepatocellular Carcinoma. Journal of the American College of Surgeons. 2008. 206(2): p. 281-291.

  138. White R, Winston C, Gönen M, D’Angelica M, Jarnagin W, Fong Y, Conlon K, Brennan M, and Allen P. Current Utility of Staging Laparoscopy for Pancreatic and Peripancreatic Neoplasms. Journal of the American College of Surgeons. 2008. 206(3): p. 445-450.

  139. Kattan MW and Gönen M. The prediction philosophy in statistics. Urologic Oncology: Seminars and Original Investigations. 2008. 26(3): p. 316-319.

  140. Allen PJ, Reiner AS, Gönen M, Klimstra DK, Blumgart LH, Brennan MF, D’Angelica M, Dematteo R, Fong Y, and Jarnagin WR. Extrahepatic cholangiocarcinoma: A comparison of patients with resected proximal and distal lesions. HPB. 2008. 10(5): p. 341-346.

  141. Elkin EB, Ishill N, Riley GF, Bach PB, Gönen M, Begg CB, and Schrag D. Disenrollment from medicare managed care among beneficiaries with and without a cancer diagnosis. Journal of the National Cancer Institute. 2008. 100(14): p. 1013-1021.

  142. Greco C, Nehmeh SA, Schöder H, Gönen M, Raphael B, Stambuk HE, Humm JL, Larson SM, and Lee NY. Evaluation of different methods of 18F-FDG-PET target volume delineation in the radiotherapy of head and neck cancer. American Journal of Clinical Oncology: Cancer Clinical Trials. 2008. 31(5): p. 439-445.

  143. Kattan MW, Gönen M, Jarnagin WR, DeMatteo R, D’Angelica M, Weiser M, Blumgart LH, and Fong Y. A nomogram for predicting disease-specific survival after hepatic resection for metastatic colorectal cancer. Annals of Surgery. 2008. 247(2): p. 282-287.

  144. Ito H, Are C, Gönen M, D’Angelica M, DeMatteo RP, Kemeny NE, Fong Y, Blumgart LH, and Jarnagin WR. Effect of postoperative morbidity on long-term survival after hepatic resection for metastatic colorectal cancer. Annals of Surgery. 2008. 247(6): p. 994-1002.

  145. D’Angelica M and Gönen M. Impact of margin width on outcome after resection of colorectal liver metastases [4]. Annals of Surgery. 2008. 247(5): p. 905-906.

  146. Endo I, Gönen M, Yopp AC, Dalal KM, Zhou Q, Klimstra D, D’Angelica M, Dematteo RP, Fong Y, Schwartz L, Kemeny N, O’Reilly E, Abou-Alfa GK, Shimada H, Blumgart LH, and Jarnagin WR. Intrahepatic cholangiocarcinoma: Rising frequency, improved survival, and determinants of outcome after resection. Annals of Surgery. 2008. 248(1): p. 84-96.

  147. Jarnagin WR, Gönen M, Maithel SK, Fong Y, Dangelica MI, Dematteo RP, Grant F, Wuest D, Kundu K, Blumgart LH, and Fischer M. A prospective randomized trial of acute normovolemic hemodilution compared to standard intraoperative management in patients undergoing major hepatic resection. Annals of Surgery. 2008. 248(3): p. 360-368.

  148. Gold JS, Are C, Kornprat P, Jarnagin WR, Gönen M, Fong Y, DeMatteo RP, Blumgart LH, and D’Angelica M. Increased use of parenchymal-sparing surgery for bilateral liver metastases from colorectal cancer is associated with improved mortality without change in oncologic outcome: Trends in treatment over time in 440 patients. Annals of Surgery. 2008. 247(1): p. 109-117.

  149. Sofocleous CT, Nascimento RG, Petrovic LM, Klimstra DS, Gönen M, Brown KT, Brody LA, Covey AM, Thornton RH, Fong Y, Solomon SB, Schwartz LH, Dematteo RP, and Getrajdman GI. Histopathologic and immunohistochemical features of tissue adherent to multitined electrodes after RF ablation of liver malignancies can help predict local tumor progression: Initial results 1. Radiology. 2008. 249(1): p. 364-374.

  150. Sawai A, Chandarlapaty S, Greulich H, Gönen M, Ye Q, Arteaga CL, Sellers W, Rosen N, and Solit DB. Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel. Cancer Research. 2008. 68(2): p. 589-596.

  151. Tse AN, Klimstra DS, Gönen M, Shah M, Sheikh T, Sikorski R, Carvajal R, Mui J, Tipian C, O’Reilly E, Chung K, Maki R, Lefkowitz R, Brown K, Manova-Todorova K, Wu N, Egorin MJ, Kelsen D, and Schwartz GK. A phase 1 dose-escalation study of irinotecan in combination with 17-allylamino-17-demethoxygeldanamycin in patients with solid tumors. Clinical Cancer Research. 2008. 14(20): p. 6704-6711.

  152. Paoluzzi L, Gönen M, Gardner JR, Mastrella J, Yang D, Holmlund J, Sorensen M, Leopold L, Manova K, Marcucci G, Heaney ML, and O’Connor OA. Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. Blood. 2008. 111(11): p. 5350-5358.

  153. Paoluzzi L, Gönen M, Bhagat G, Furman RR, Gardner JR, Scotto L, Gueorguiev VD, Heaney ML, Manova K, and O’Connor OA. The BH3-only mimetic ABT-737 synergizes the antineoplastic activity of proteasome inhibitors in lymphoid malignancies. Blood. 2008. 112(7): p. 2906-2916.

  154. Vickers AJ, Cronin AM, Elkin EB, and Gönen M. Extensions to decision curve analysis, a novel method for evaluating diagnostic tests, prediction models and molecular markers. BMC Medical Informatics and Decision Making. 2008. 8.

  155. Weiser MR, Landmann RG, Kattan MW, Gönen M, Shia J, Chou J, Paty PB, Guillem JG, Temple LK, Schrag D, Saltz LB, and Wong WD. Individualized prediction of colon cancer recurrence using a nomogram. Journal of Clinical Oncology. 2008. 26(3): p. 380-385.

  156. Gönen M. Area between curves: What you see is not what you get. Journal of Clinical Oncology. 2008. 26(13): p. 2236.

  157. Endo I, House MG, Klimstra DS, Gönen M, D’Angelica M, DeMatteo RP, Fong Y, Blumgart LH, and Jarnagin WR. Clinical significance of intraoperative bile duct margin assessment for hilar cholangiocarcinoma. Annals of Surgical Oncology. 2008. 15(8): p. 2104-2112.

  158. Barbour AP, Jones M, Gönen M, Gotley DC, Thomas J, Thomson DB, Burmeister B, and Smithers BM. Refining esophageal cancer staging after neoadjuvant therapy: Importance of treatment response. Annals of Surgical Oncology. 2008. 15(10): p. 2894-2902.

  159. Maithel SK, Maloney S, Winston C, Gönen M, D’Angelica MI, Dematteo RP, Jarnagin WR, Brennan MF, and Allen PJ. Preoperative CA 19-9 and the yield of staging laparoscopy in patients with radiographically resectable pancreatic adenocarcinoma. Annals of Surgical Oncology. 2008. 15(12): p. 3512-3520.

  160. Pandit-Taskar N, O’Donoghue JA, Morris MJ, Wills EA, Schwartz LH, Gönen M, Scher HI, Larson SM, and Divgi CR. Antibody mass escalation study in patients with castration-resistant prostate cancer using 111In-J591: Lesion detectability and dosimetric projections for 90Y radioimmunotherapy. Journal of Nuclear Medicine. 2008. 49(7): p. 1066-1074.

  161. Silberhumer GR, Zakian K, Malhotra S, Brader P, Gönen M, Koutcher J, and Fong Y. Relationship between 31P metabolites and oncolytic viral therapy sensitivity in human colorectal cancer xenografts. British Journal of Surgery. 2009. 96(7): p. 809-816.

  162. Vickers AJ, Cronin AM, Kattan MW, Gönen M, Scardino PT, Milowsky MI, Dalbagni G, and Bochner BH. Clinical benefits of a multivariate prediction model for bladder cancer: A decision analytic approach. Cancer. 2009. 115(23): p. 5460-5469.

  163. Nash GM, Weiser MR, Guillem JG, Temple LK, Shia J, Gönen M, Wong WD, and Paty PB. Long-term survival after transanal excision of T1 rectal cancer. Diseases of the Colon and Rectum. 2009. 52(4): p. 577-582.

  164. Moskowitz CS, Jia X, Schwartz LH, and Gönen M. A simulation study to evaluate the impact of the number of lesions measured on response assessment. European Journal of Cancer. 2009. 45(2): p. 300-310.

  165. Auer RC, Schulman AR, Tuorto S, Gönen M, Gonsalves J, Schwartz L, Ginsberg MS, and Fong Y. Use of Helical CT Is Associated with an Increased Incidence of Postoperative Pulmonary Emboli in Cancer Patients with No Change in the Number of Fatal Pulmonary Emboli. Journal of the American College of Surgeons. 2009. 208(5): p. 871-878.

  166. Gold JS, Gönen M, Gutiérrez A, Broto JM, García-del-Muro X, Smyrk TC, Maki RG, Singer S, Brennan MF, Antonescu CR, Donohue JH, and DeMatteo RP. Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis. The Lancet Oncology. 2009. 10(11): p. 1045-1052.

  167. Can AS, Bersot TP, and Gönen M. Anthropometric indices and their relationship with cardiometabolic risk factors in a sample of Turkish adults. Public Health Nutrition. 2009. 12(4): p. 538-546.

  168. Noy A, Schöder H, Gönen M, Weissler M, Ertelt K, Cohler C, Portlock C, Hamlin P, and Yeung HWD. The majority of transformed lymphomas have high standardized uptake values (SUVs) on positron emission tomography (PET) scanning similar to diffuse large B-cell lymphoma (DLBCL). Annals of Oncology. 2009. 20(3): p. 508-512.

  169. Jarnagin WR, Schwartz LH, Gultekin DH, Gönen M, Haviland D, Shia J, D’Angelica M, Fong Y, DeMatteo R, Tse A, Blumgart LH, and Kemeny N. Regional chemotherapy for unresectable primary liver cancer: Results of a phase II clinical trial and assessment of DCE-MRI as a biomarker of survival. Annals of Oncology. 2009. 20(9): p. 1589-1595.

  170. Jhawer M, Coit D, Brennan M, Qin LX, Gönen M, Klimstra D, Tang L, Kelsen DP, and Shah MA. Perineural invasion after preoperative chemotherapy predicts poor survival in patients with locally advanced gastric cancer: Gene expression analysis with pathologic validation. American Journal of Clinical Oncology: Cancer Clinical Trials. 2009. 32(4): p. 356-363.

  171. Sima CS, Jarnagin WR, Fong Y, Elkin E, Fischer M, Wuest D, D’Angelica M, Dematteo RP, Blumgart LH, and Gönen M. Predicting the risk of perioperative transfusion for patients undergoing elective hepatectomy. Annals of Surgery. 2009. 250(6): p. 914-921.

  172. Katz SC, Shia J, Liau KH, Gönen M, Ruo L, Jarnagin WR, Fong Y, D’Angelica MI, Blumgart LH, and Dematteo RP. Operative blood loss independently predicts recurrence and survival after resection of hepatocellular carcinoma. Annals of Surgery. 2009. 249(4): p. 617-623.

  173. O’Connor OA, Moskowitz C, Portlock C, Hamlin P, Straus D, Dumitrescu O, Sarasohn D, Gönen M, Butos J, Neylon E, Hamelers R, Mac-Gregor Cortelli B, Blumel S, Zelenetz AD, Gordon L, Wright JJ, Vose J, Cooper B, and Winter J. Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survivals compared with patients with relapsed disease following treatment with single agent bortezomib: Results of a multicentre phase 2 clinical trial. British Journal of Haematology. 2009. 145(1): p. 34-39.

  174. Rathkopf D, Dickson MA, Feldman DR, Carvajal RD, Shah MA, Wu N, Lefkowitz R, Gönen M, Cane LM, Dials HJ, Winkelmann JL, Bosl GJ, and Schwartz GK. Phase I study of flavopiridol with oxaliplatin and fluorouracil/leucovorin in advanced solid tumors. Clinical Cancer Research. 2009. 15(23): p. 7405-7411.

  175. Carvajal RD, Tse A, Shah MA, Lefkowitz RA, Gönen M, Gilman-Rosen L, Kortmansky J, Kelsen DP, Schwartz GK, and O’Reilly EM. A phase II study of flavopiridol (alvocidib) in combination with docetaxel in refractory, metastatic pancreatic cancer. Pancreatology. 2009. 9(4): p. 404-409.

  176. Sofocleous CT, Petre N, Manova-Todorova K, Petrovic L, and Gönen M. Re: Assessment of viable tumour tissue attached to needle applicators after local ablation of liver tumours. Digestive Surgery. 2009. 26(5): p. 434-435.

  177. Gönen M. Bayesian clinical trials: No more excuses. Clinical Trials. 2009. 6(3): p. 203-204.

  178. Miksad RA, Gönen M, Lynch TJ, and Roberts Jr TG. Interpreting trial results in light of conflicting evidence: A bayesian analysis of adjuvant chemotherapy for non-small-cell lung cancer. Journal of Clinical Oncology. 2009. 27(13): p. 2245-2252.

  179. Gönen M, Schrag DM, and Weiser MR. Nodal staging score: A tool to assess adequate staging of node-negative colon cancer. Journal of Clinical Oncology. 2009. 27(36): p. 6166-6171.

  180. Ariyan C, Brady MS, Gönen M, Busam K, and Coit D. Positive nonsentinel node status predicts mortality in patients with cutaneous melanoma. Annals of Surgical Oncology. 2009. 16(1): p. 186-190.

  181. Fahy BN, D’Angelica M, Dematteo RP, Blumgart LH, Weiser MR, Ostrovnaya I, Gönen M, and Jarnagin WR. Synchronous hepatic metastases from colon cancer: Changing treatment strategies and results of surgical intervention. Annals of Surgical Oncology. 2009. 16(2): p. 361-370.

  182. Strong VE, Devaud N, Allen PJ, Gönen M, Brennan MF, and Coit D. Laparoscopic versus open subtotal gastrectomy for adenocarcinoma: A case-control study. Annals of Surgical Oncology. 2009. 16(6): p. 1507-1513.

  183. Carpizo DR, Are C, Jarnagin W, Dematteo R, Fong Y, Gönen M, Blumgart L, and D’Angelica M. Liver resection for metastatic colorectal cancer in patients with concurrent extrahepatic disease: Results in 127 patients treated at a single center. Annals of Surgical Oncology. 2009. 16(8): p. 2138-2146.

  184. Katz SC, Pillarisetty V, Bamboat ZM, Shia J, Hedvat C, Gönen M, Jarnagin W, Fong Y, Blumgart L, D’Angelica M, and DeMatteo RP. T cell infiltrate predicts long-term survival following resection of colorectal cancer liver metastases. Annals of Surgical Oncology. 2009. 16(9): p. 2524-2530.

  185. Kelly KJ, Wong J, Gladdy R, Moore-Dalal K, Woo Y, Gönen M, Brennan M, Allen P, Fong Y, and Coit D. Prognostic impact of RT-PCR-based detection of peritoneal micrometastases in patients with pancreatic cancer undergoing curative resection. Annals of Surgical Oncology. 2009. 16(12): p. 3333-3339.

  186. Grewal RK, Larson SM, Pentlow CE, Pentlow KS, Gönen M, Qualey R, Natbony L, and Tuttle RM. Salivary gland side effects commonly develop several weeks after initial radioactive iodine ablation. Journal of Nuclear Medicine. 2009. 50(10): p. 1605-1610.

  187. Bamboat ZM, Stableford JA, Plitas G, Burt BM, Nguyen HM, Welles AP, Gönen M, Young JW, and DeMatteo RP. Human liver dendritic cells promote T cell hyporesponsiveness. Journal of Immunology. 2009. 182(4): p. 1901-1911.

  188. Osborne JR, Port E, Gönen M, Doane A, Yeung H, Gerald W, Cook JB, and Larson S. 18F-FDG PET of locally invasive breast cancer and association of estrogen receptor status with standardized uptake value: microarray and immunohistochemical analysis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2010. 51(4): p. 543-550.

  189. Morris K, Tuorto S, Gönen M, Schwartz L, DeMatteo R, D’Angelica M, Jarnagin WR, and Fong Y. Simple measurement of intra-abdominal fat for abdominal surgery outcome prediction. Archives of Surgery. 2010. 145(11): p. 1069-1073.

  190. Neuman HB, Morrogh M, Gönen M, Van Zee KJ, Morrow M, and King TA. Stage IV breast cancer in the era of targeted therapy: Does surgery of the primary tumor matter? Cancer. 2010. 116(5): p. 1226-1233.

  191. Chou JF, Row D, Gönen M, Liu YH, Schrag D, and Weiser MR. Clinical and pathologic factors that predict lymph node yield from surgical specimens in colorectal cancer: A population-based study. Cancer. 2010. 116(11): p. 2560-2570.

  192. Morrogh M, Miner TJ, Park A, Jenckes A, Gönen M, Seidman A, Morrow M, Jaques DP, and King TA. A prospective evaluation of the durability of palliative interventions for patients with metastatic breast cancer. Cancer. 2010. 116(14): p. 3338-3347.

  193. Olson SH, Chou JF, Ludwig E, O’Reilly E, Allen PJ, Jarnagin WR, Bayuga S, Simon J, Gönen M, Reisacher WR, and Kurtz RC. Allergies, obesity, other risk factors and survival from pancreatic cancer. International Journal of Cancer. 2010. 127(10): p. 2412-2419.

  194. Gönen M. The Bayesian t-test and beyond. Methods in molecular biology (Clifton, N.J.). 2010. 620: p. 179-199.

  195. Gönen M, Schrag D, and Weiser MR. Nodal staging score: A tool to assess adequate staging of node-negative colon cancer. Diseases of the Colon and Rectum. 2010. 53(7): p. 1101.

  196. Nash GM, Weiss A, Dasgupta R, Gönen M, Guillem JG, and Wong WD. Close distal margin and rectal cancer recurrence after sphincter-preserving rectal resection. Diseases of the Colon and Rectum. 2010. 53(10): p. 1365-1373.

  197. Goteti K, Garner CE, Utley L, Dai J, Ashwell S, Moustakas DT, Gönen M, Schwartz GK, Kern SE, Zabludoff S, and Brassil PJ. Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents. Cancer Chemotherapy and Pharmacology. 2010. 66(2): p. 245-254.

  198. Dickson MA, Shah MA, Rathkopf D, Tse A, Carvajal RD, Wu N, Lefkowitz RA, Gönen M, Cane LM, Dials HJ, and Schwartz GK. A phase i clinical trial of FOLFIRI in combination with the pan-cyclin-dependent kinase (CDK) inhibitor flavopiridol. Cancer Chemotherapy and Pharmacology. 2010. 66(6): p. 1113-1121.

  199. House MG, Ito H, Gönen M, Fong Y, Allen PJ, DeMatteo RP, Brennan MF, Blumgart LH, Jarnagin WR, and D’Angelica MI. Survival after Hepatic Resection for Metastatic Colorectal Cancer: Trends in Outcomes for 1,600 Patients during Two Decades at a Single Institution. Journal of the American College of Surgeons. 2010. 210(5): p. 744-752.

  200. Jayaraman S, Gönen M, Brennan MF, D’Angelica MI, Dematteo RP, Fong Y, Jarnagin WR, and Allen PJ. Laparoscopic distal pancreatectomy: Evolution of a technique at a single institution. Journal of the American College of Surgeons. 2010. 211(4): p. 503-509.

  201. Selçuk Can A, Akal Yildiz E, Samur G, Rakcoǧlu N, Pekcan G, Özbayrakçi S, Palaoǧlu KE, Gönen M, and Bersot TP. Optimal waist:height ratio cut-off point for cardiometabolic risk factors in Turkish adults. Public Health Nutrition. 2010. 13(4): p. 488-495.

  202. Moreira AL, Gönen M, Rekhtman N, and Downey RJ. Progenitor stem cell marker expression by pulmonary carcinomas. Modern Pathology. 2010. 23(6): p. 889-895.

  203. Gönen M and Weiser MR. Whither TNM? Seminars in Oncology. 2010. 37(1): p. 27-30.

  204. Schmidtlein CR, Beattie BJ, Bailey DL, Akhurst TJ, Wang W, Gönen M, Kirov AS, and Humm JL. Using an external gating signal to estimate noise in PET with an emphasis on tracer avid tumors. Physics in Medicine and Biology. 2010. 55(20): p. 6299-6326.

  205. Tuttle RM, Tala H, Shah J, Leboeuf R, Ghossein R, Gönen M, Brokhin M, Omry G, Fagin JA, and Shaha A. Estimating risk of recurrence in differentiated thyroid cancer after total thyroidectomy and radioactive iodine remnant ablation: Using response to therapy variables to modify the initial risk estimates predicted by the new American thyroid association staging system. Thyroid. 2010. 20(12): p. 1341-1349.

  206. Babur Ö, Demir E, Gönen M, Sander C, and Dogrusoz U. Discovering modulators of gene expression. Nucleic Acids Research. 2010. 38(17): p. 5648-5656.

  207. Steyerberg EW, Vickers AJ, Cook NR, Gerds T, Gönen M, Obuchowski N, Pencina MJ, and Kattan MW. Assessing the performance of prediction models: A framework for traditional and novel measures. Epidemiology. 2010. 21(1): p. 128-138.

  208. Klimstra DS, Modlin IR, Adsay NV, Chetty R, Deshpande V, Gönen M, Jensen RT, Kidd M, Kulke MH, Lloyd RV, Moran C, Moss SF, Oberg K, Otoole D, Rindi G, Robert ME, Suster S, Tang LH, Tzen CY, Washington MK, Wiedenmann B, and Yao J. Pathology reporting of neuroendocrine tumors: Application of the delphic consensus process to the development of a minimum pathology data set. American Journal of Surgical Pathology. 2010. 34(3): p. 300-313.

  209. Ito K, Ito H, Allen PJ, Gönen M, Klimstra D, D’Angelica MI, Fong Y, Dematteo RP, Brennan MF, Blumgart LH, and Jarnagin WR. Adequate lymph node assessment for extrahepatic bile duct adenocarcinoma. Annals of Surgery. 2010. 251(4): p. 675-681.

  210. Strong VE, Song KY, Park CH, Jacks LM, Gönen M, Shah M, Coit DG, and Brennan MF. Comparison of gastric cancer survival following R0 resection in the United States and Korea using an internationally validated nomogram. Annals of Surgery. 2010. 251(4): p. 640-646.

  211. Fischer M, Matsuo K, Gönen M, Grant F, Dematteo RP, D’Angelica MI, Mascarenhas J, Brennan MF, Allen PJ, Blumgart LH, and Jarnagin WR. Relationship between intraoperative fluid administration and perioperative outcome after pancreaticoduodenectomy: Results of a prospective randomized trial of acute normovolemic hemodilution compared with standard intraoperative management. Annals of Surgery. 2010. 252(6): p. 952-958.

  212. Katz SC, Donkor C, Glasgow K, Pillarisetty VG, Gönen M, Espat NJ, Klimstra DS, D’Angelica MI, Allen PJ, Jarnagin W, Dematteo RP, Brennan MF, and Tang LH. T cell infiltrate and outcome following resection of intermediate-grade primary neuroendocrine tumours and liver metastases. HPB. 2010. 12(10): p. 674-683.

  213. O’Connor OA, Portlock C, Moskowitz C, Hamlin P, Straus D, Gerecitano J, Gönen M, Dumitrescu O, Sarasohn D, Butos J, Neylon E, Cortelli BMG, Blumel S, Evens AM, Zelenetz AD, Wright J, Cooper B, Winter J, and Vose J. Time to treatment response in patients with follicular lymphoma treated with bortezomib is longer compared with other histologic subtypes. Clinical Cancer Research. 2010. 16(2): p. 719-726.

  214. Meirelles GSP, Schöder H, Ravizzini GC, Gönen M, Fox JJ, Humm J, Morris MJ, Scher HI, and Larson SM. Prognostic value of baseline [ 18F] fluorodeoxyglucose positron emission tomography and 99mTc-MDP bone scan in progressing metastatic prostate cancer. Clinical Cancer Research. 2010. 16(24): p. 6093-6099.

  215. Silberhumer GR, Brader P, Wong J, Serganova IS, Gönen M, Gonzalez SJ, Blasberg R, Zamarin D, and Fong Y. Genetically engineered oncolytic newcastle disease virus effectively induces sustained remission of malignant pleural mesothelioma. Molecular Cancer Therapeutics. 2010. 9(10): p. 2761-2769.

  216. Park SY, Gönen M, Kim HJ, Michor F, and Polyak K. Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. Journal of Clinical Investigation. 2010. 120(2): p. 636-644.

  217. Marubayashi S, Koppikar P, Taldone T, Abdel-Wahab O, West N, Bhagwat N, Caldas-Lopes E, Ross KN, Gönen M, Gozman A, Ahn JH, Rodina A, Ouerfelli O, Yang G, Hedvat C, Bradner JE, Chiosis G, and Levine RL. HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans. Journal of Clinical Investigation. 2010. 120(10): p. 3578-3593.

  218. Gönen M and Heller G. Lehmann family of ROC curves. Medical Decision Making. 2010. 30(4): p. 509-517.

  219. Robson PC, Heffernan N, Gönen M, Thornton R, Brody LA, Holmes R, Brown KT, Covey AM, Fleischer D, Getrajdman GI, Jarnagin W, Sofocleous C, Blumgart L, and D’Angelica M. Prospective study of outcomes after percutaneous biliary drainage for malignant biliary obstruction. Annals of Surgical Oncology. 2010. 17(9): p. 2303-2311.

  220. Feeney J, Horwitz S, Gönen M, and Schöder H. Characterization of T-cell lymphomas by FDG PET/CT. American Journal of Roentgenology. 2010. 195(2): p. 333-340.

  221. Grewal RK, Tuttle RM, Fox J, Borkar S, Chou JF, Gönen M, Strauss HW, Larson SM, and Schöder H. The effect of posttherapy 131I SPECT/CT on risk classification and management of patients with differentiated thyroid cancer. Journal of Nuclear Medicine. 2010. 51(9): p. 1361-1367.

  222. Singnurkar A, Solomon SB, Gönen M, Larson SM, and Schöder H. 18F-FDG PET/CT for the prediction and detection of local recurrence after radiofrequency ablation of malignant lung lesions. Journal of Nuclear Medicine. 2010. 51(12): p. 1833-1840.

  223. Vickers AJ, Cronin AM, Kattan MW, Gönen M, Scardino PT, Milowsky MI, Dalbagni G, Bochner BH, Simons JP, Ng SC, McDade TP, Zhou Z, Earle CC, and Tseng JF. Erratum: Clinical benefits of a multivariate prediction model for bladder cancer: A decision analytic approach (Cancer (2009) 115 (5460-5469)). Cancer. 2011. 117(16): p. 3867.

  224. Qi J, Shukla-Dave A, Fong Y, Gönen M, Schwartz LH, Jarnagin WM, Koutcher JA, and Zakian KL. 31P MR spectroscopic imaging detects regenerative changes in human liver stimulated by portal vein embolization. Journal of Magnetic Resonance Imaging. 2011. 34(2): p. 336-344.

  225. Ghosh P, Nathoo F, Gönen M, and Tiwari RC. Assessing noninferiority in a three-arm trial using the Bayesian approach. Statistics in Medicine. 2011. 30(15): p. 1795-1808.

  226. González SJ, Wong J, González L, Brader P, Zakowski M, Gönen M, Fong Y, and Strong VE. Novel handheld PET probes provide intraoperative localization of PET-avid lymph nodes. Surgical Endoscopy and Other Interventional Techniques. 2011. 25(10): p. 3214-3221.

  227. Comen E, Balistreri L, Gönen M, Dutra-Clarke A, Fazio M, Vijai J, Stadler Z, Kauff N, Kirchhoff T, Hudis C, Offit K, and Robson M. Discriminatory accuracy and potential clinical utility of genomic profiling for breast cancer risk in BRCA-negative women. Breast Cancer Research and Treatment. 2011. 127(2): p. 479-487.

  228. Dickson MA, Rathkopf DE, Carvajal RD, Grant S, Roberts JD, Reid JM, Ames MM, McGovern RM, Lefkowitz RA, Gönen M, Cane LM, Dials HJ, and Schwartz GK. A phase I pharmacokinetic study of pulse-dose vorinostat with flavopiridol in solid tumors. Investigational New Drugs. 2011. 29(5): p. 1004-1012.

  229. Butte JM, Brennan MF, Gönen M, Tang LH, D’Angelica MI, Fong Y, DeMatteo RP, Jarnagin WR, and Allen PJ. Solid pseudopapillary tumors of the pancreas. clinical features, surgical outcomes, and long-term survival in 45 consecutive patients from a single center. Journal of Gastrointestinal Surgery. 2011. 15(2): p. 350-357.

  230. González SJ, González L, Wong J, Brader P, Zakowski M, Gönen M, Daghighian F, Fong Y, and Strong VE. An analysis of the utility of handheld PET probes for the intraoperative localization of malignant tissue. Journal of Gastrointestinal Surgery. 2011. 15(2): p. 358-366.

  231. Terezakis SA, Hunt MA, Kowalski A, McCann P, Schmidtlein CR, Reiner A, Gönen M, Kirov AS, Gonzales AM, Schöder H, and Yahalom J. [18F]FDG-positron emission tomography coregistration with computed tomography scans for radiation treatment planning of lymphoma and hematologic malignancies. International Journal of Radiation Oncology Biology Physics. 2011. 81(3): p. 615-622.

  232. Gaujoux S, Brennan MF, Gönen M, D’Angelica MI, DeMatteo R, Fong Y, Schattner M, DiMaio C, Janakos M, Jarnagin WR, and Allen PJ. Cystic lesions of the pancreas: Changes in the presentation and management of 1,424 patients at a single institution over a 15-year time period. Journal of the American College of Surgeons. 2011. 212(4): p. 590-600.

  233. Medina OP, Pillarsetty N, Glekas A, Punzalan B, Longo V, Gönen M, Zanzonico P, Smith-Jones P, and Larson SM. Optimizing tumor targeting of the lipophilic EGFR-binding radiotracer SKI 243 using a liposomal nanoparticle delivery system. Journal of Controlled Release. 2011. 149(3): p. 292-298.

  234. Sofocleous CT, Petre EN, Gönen M, Brown KT, Solomon SB, Covey AM, Alago W, Brody LA, Thornton RH, D’Angelica M, Fong Y, and Kemeny NE. CT-guided radiofrequency ablation as a salvage treatment of colorectal cancer hepatic metastases developing after hepatectomy. Journal of Vascular and Interventional Radiology. 2011. 22(6): p. 755-761.

  235. Butte JM, Do RK, Shia J, Gönen M, D’Angelica MI, Getrajdman GI, Allen PJ, Fong Y, Dematteo RP, Klimstra DS, and Jarnagin WR. Liver angiomyolipomas: A clinical, radiologic, and pathologic analysis of 22 patients from a single center. Surgery. 2011. 150(3): p. 557-567.

  236. Can AS, Bersot TP, and Gönen M. Erratum: Anthropometric indices and their relationship with cardiometabolic risk factors in a sample of Turkish adults-Corrigendum (Public Health Nutrition DOI: 10.1017/S1368980008002474). Public Health Nutrition. 2011. 14(1): p. 189.

  237. Fields RC, Strong VE, Gönen M, Goodman KA, Rizk NP, Kelsen DP, Ilson DH, Tang LH, Brennan MF, Coit DG, and Shah MA. Recurrence and survival after pathologic complete response to preoperative therapy followed by surgery for gastric or gastrooesophageal adenocarcinoma. British Journal of Cancer. 2011. 104(12): p. 1840-1847.

  238. D’Angelica M, Ammori J, Gönen M, Klimstra DS, Low PS, Murphy L, Weiser MR, Paty PB, Fong Y, Dematteo RP, Allen P, Jarnagin WR, and Shia J. Folate receptor-α expression in resectable hepatic colorectal cancer metastases: Patterns and significance. Modern Pathology. 2011. 24(9): p. 1221-1228.

  239. Gönen M. Bias, biostatistics, and prognostic factors. Journal of Thoracic Oncology. 2011. 6(7 SUPPL. 3): p. S1705-S1709.

  240. Shia J, Stadler Z, Weiser MR, Rentz M, Gönen M, Tang LH, Vakiani E, Katabi N, Xiong X, Markowitz AJ, Shike M, Guillem J, and Klimstra DS. Immunohistochemical staining for dna mismatch repair proteins in intestinal tract carcinoma: How reliable are biopsy samples? American Journal of Surgical Pathology. 2011. 35(3): p. 447-454.

  241. Meirelles GSP, Gönen M, and Strauss HW. 18F-FDG uptake and calcifications in the thoracic aorta on positron emission tomography/computed tomography examinations: Frequency and stability on serial scans. Journal of Thoracic Imaging. 2011. 26(1): p. 54-62.

  242. Sima CS, Jarnagin WR, and Gönen M. Reply. Annals of Surgery. 2011. 253(3): p. 632.

  243. House MG, Kemeny NE, Gönen M, Fong Y, Allen PJ, Paty PB, Dematteo RP, Blumgart LH, Jarnagin WR, and D’Angelica MI. Comparison of adjuvant systemic chemotherapy with or without hepatic arterial infusional chemotherapy after hepatic resection for metastatic colorectal cancer. Annals of Surgery. 2011. 254(6): p. 851-856.

  244. Nash GM, Row D, Weiss A, Shia J, Guillem JG, Paty PB, Gönen M, R. Weiser M, Temple LK, Fitzmaurice G, and Wong WD. A predictive model for lymph node yield in colon cancer resection specimens. Annals of Surgery. 2011. 253(2): p. 318-322.

  245. Ito H, Ito K, D’Angelica M, Gönen M, Klimstra D, Allen P, Dematteo RP, Fong Y, Blumgart LH, and Jarnagin WR. Accurate staging for gallbladder cancer: Implications for surgical therapy and pathological assessment. Annals of Surgery. 2011. 254(2): p. 320-325.

  246. Butte JM, Gönen M, Allen PJ, D’Angelica MI, Kingham TP, Fong Y, Dematteo RP, Blumgart L, and Jarnagin WR. The role of laparoscopic staging in patients with incidental gallbladder cancer. HPB. 2011. 13(7): p. 463-472.

  247. Schwartz J, Humm JL, Gönen M, Kalaigian H, Schoder H, Larson SM, and Nehmeh SA. Repeatability of SUV measurements in serial PET. Medical Physics. 2011. 38(5): p. 2629-2638.

  248. Dickson MA, Carvajal RD, Merrill Jr AH, Gönen M, Cane LM, and Schwartz GK. A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. Clinical Cancer Research. 2011. 17(8): p. 2484-2492.

  249. Kemeny NE, Schwartz L, Gönen M, Yopp A, Gultekin D, D’Angelica MI, Fong Y, Haviland D, Gewirtz AN, Allen P, and Jarnagin WR. Treating primary liver cancer with hepatic arterial infusion of floxuridine and dexamethasone: Does the addition of systemic bevacizumab improve results? Oncology. 2011. 80(3-4): p. 153-159.

  250. Marotta LLC, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, and Polyak K. The JAK2/STAT3 signaling pathway is required for growth of CD44 +CD24 - stem cell-like breast cancer cells in human tumors. Journal of Clinical Investigation. 2011. 121(7): p. 2723-2735.

  251. Tang M, Gönen M, Quintas-Cardama A, Cortes J, Kantarjian H, Field C, Hughes TP, Branford S, and Michor F. Dynamics of chronic myeloid leukemia response to long-term targeted therapy reveal treatment effects on leukemic stem cells. Blood. 2011. 118(6): p. 1622-1631.

  252. Haddad D, Chen NG, Zhang Q, Chen CH, Yu YA, Gonzalez L, Carpenter SG, Carson J, Au J, Mittra A, Gönen M, Zanzonico PB, Fong Y, and Szalay AA. Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus. Journal of Translational Medicine. 2011. 9.

  253. Weiser MR, Gon̈en M, Chou JF, Kattan MW, and Schrag D. Predicting survival after curative colectomy for cancer: Individualizing colon cancer staging. Journal of Clinical Oncology. 2011. 29(36): p. 4796-4802.

  254. Govindarajan A, Gon̈en M, Weiser MR, Shia J, Temple LK, Guillem JG, Paty PB, and Nash GM. Challenging the feasibility and clinical significance of current guidelines on lymph node examination in rectal cancer in the era of neoadjuvant therapy. Journal of Clinical Oncology. 2011. 29(34): p. 4568-4573.

  255. Maker AV, Katabi N, Gönen M, Dematteo RP, D’Angelica MI, Fong Y, Jarnagin WR, Brennan MF, and Allen PJ. Pancreatic cyst fluid and serum mucin levels predict dysplasia in intraductal papillary mucinous neoplasms of the pancreas. Annals of Surgical Oncology. 2011. 18(1): p. 199-206.

  256. D’Angelica M, Kornprat P, Gönen M, DeMatteo RP, Fong Y, Blumgart LH, and Jarnagin WR. Effect on outcome of recurrence patterns after hepatectomy for colorectal metastases. Annals of Surgical Oncology. 2011. 18(4): p. 1096-1103.

  257. Mezhir JJ, Gönen M, Ammori JB, Strong VE, Brennan MF, and Coit DG. Treatment and outcome of patients with gastric remnant cancer after resection for peptic ulcer disease. Annals of Surgical Oncology. 2011. 18(3): p. 670-676.

  258. Karakousis GC, Singer S, Zheng J, Gönen M, Coit D, Dematteo RP, and Strong VE. Laparoscopic versus open gastric resections for primary gastrointestinal stromal tumors (GISTs): A size-matched comparison. Annals of Surgical Oncology. 2011. 18(6): p. 1599-1605.

  259. Yopp AC, Schwartz LH, Kemeny N, Gultekin DH, Gönen M, Bamboat Z, Shia J, Haviland D, D’Angelica MI, Fong Y, Dematteo RP, Allen PJ, and Jarnagin WR. Antiangiogenic therapy for primary liver cancer: Correlation of changes in dynamic contrast-enhanced magnetic resonance imaging with tissue hypoxia markers and clinical response. Annals of Surgical Oncology. 2011. 18(8): p. 2192-2199.

  260. Deodhar A, Dickfeld T, Single GW, Hamilton Jr WC, Thornton RH, Sofocleous CT, Maybody M, Gónen M, Rubinsky B, and Solomon SB. Irreversible electroporation near the heart: Ventricular arrhythmias can be prevented with ECG synchronization. American Journal of Roentgenology. 2011. 196(3): p. W330-W335.

  261. Hambly NM, Gönen M, Gerst SR, Li D, Jia X, Mironov S, Sarasohn D, Fleming SE, and Hann LE. Implementation of evidence-based guidelines for thyroid nodule biopsy: A model for establishment of practice standards. American Journal of Roentgenology. 2011. 196(3): p. 655-660.

  262. Sofocleous CT, May B, Petre EN, Gönen M, Thornton RH, Alago W, Rizk NP, Dupuy DE, and Solomon SB. Pulmonary thermal ablation in patients with prior pneumonectomy. American Journal of Roentgenology. 2011. 196(5): p. W606-W612.

  263. Gerst S, Hann LE, Li D, Gönen M, Tickoo S, Sohn MJ, and Russo P. Evaluation of renal masses with contrast-enhanced ultrasound: Initial experience. American Journal of Roentgenology. 2011. 197(4): p. 897-906.

  264. Carrasquillo JA, Pandit-Taskar N, O’Donoghue JA, Humm JL, Zanzonico P, Smith-Jones PM, Divgi CR, Pryma DA, Ruan S, Kemeny NE, Fong Y, Wong D, Jaggi JS, Scheinberg DA, Gönen M, Panageas KS, Ritter G, Jungbluth AA, Old LJ, and Larson SM. 124I-huA33 antibody PET of colorectal cancer. Journal of Nuclear Medicine. 2011. 52(8): p. 1173-1180.

  265. Fox JJ, Autran-Blanc E, Morris MJ, Gavane S, Nehmeh S, Van Nuffel A, Gönen M, Schöder H, Humm JL, Scher HI, and Larson SM. Practical approach for comparative analysis of multilesion molecular imaging using a semiautomated program for PET/CT. Journal of Nuclear Medicine. 2011. 52(11): p. 1727-1732.

  266. Butte JM, Gönen M, Ding P, Goodman KA, Allen PJ, Nash GM, Guillem J, Paty PB, Saltz LB, Kemeny NE, Dematteo RP, Fong Y, Jarnagin WR, Weiser MR, and D’Angelica MI. Patterns of failure in patients with early onset (synchronous) resectable liver metastases from rectal cancer. Cancer. 2012. 118(21): p. 5414-5423.

  267. Song TJ, Fong Y, Cho SJ, Gönen M, Hezel M, Tuorto S, Choi SY, Kim YC, Suh SO, Koo BH, Chae YS, Jarnagin WR, and Klimstra DS. Comparison of hepatocellular carcinoma in American and Asian patients by tissue array analysis. Journal of Surgical Oncology. 2012. 106(1): p. 84-88.

  268. Grant FM, Protic M, Gönen M, Allen P, and Brennan MF. Intraoperative fluid management and complications following pancreatectomy. Journal of Surgical Oncology. 2012.

  269. Strong VE, Song KY, Park CH, Jacks LM, Gönen M, Shah MA, Coit DG, and Brennan MF. Comparison of disease-specific survival in the United States and Korea after resection for early-stage node-negative gastric carcinoma. Journal of Surgical Oncology. 2012.

  270. Qi J, Fong Y, Saltz L, D’Angelica MI, Kemeny NE, Gönen M, Shia J, Shukla-Dave A, Jarnagin WM, Do RKG, Schwartz LH, Koutcher JA, and Zakian KL. Serial measurement of hepatic lipids during chemotherapy in patients with colorectal cancer: A 1H MRS study. NMR in Biomedicine. 2012.

  271. Vickers AJ, Cronin AM, and Gönen M. A simple decision analytic solution to the comparison of two binary diagnostic tests. Statistics in Medicine. 2012.

  272. Seshan V, Gönen M, and Begg C. Comparing ROC curves derived from regression models. Statistics in Medicine. 2012.

  273. Wang X, Sofocleous CT, Erinjeri JP, Petre EN, Gönen M, Do KG, Brown KT, Covey AM, Brody LA, Alago W, Thornton RH, Kemeny NE, and Solomon SB. Margin Size is an Independent Predictor of Local Tumor Progression After Ablation of Colon Cancer Liver Metastases. CardioVascular and Interventional Radiology. 2012: p. 1-10.

  274. Wang X, Erinjeri JP, Jia X, Gönen M, Brown KT, Sofocleous CT, Getrajdman GI, Brody LA, Thornton RH, Maybody M, Covey AM, Siegelbaum RH, Alago W, and Solomon SB. Pattern of Retained Contrast on Immediate Postprocedure Computed tomography (CT) After Particle Embolization of Liver Tumors Predicts Subsequent Treatment Response. CardioVascular and Interventional Radiology. 2012: p. 1-9.

  275. Gollub MJ, Gultekin DH, Akin O, Do RK, Fuqua Iii JL, Gönen M, Kuk D, Weiser M, Saltz L, Schrag D, Goodman K, Paty P, Guillem J, Nash GM, Temple L, Shia J, and Schwartz LH. Dynamic contrast enhanced-MRI for the detection of pathological complete response to neoadjuvant chemotherapy for locally advanced rectal cancer. European Radiology. 2012. 22(4): p. 821-831.

  276. Atkinson TM, Li Y, Coffey CW, Sit L, Shaw M, Lavene D, Bennett AV, Fruscione M, Rogak L, Hay J, Gönen M, Schrag D, and Basch E. Reliability of adverse symptom event reporting by clinicians. Quality of Life Research. 2012. 21(7): p. 1159-1164.

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