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Xiaolin Liang

Program Analyst, Senior

Office Phone

646-888-8302

Email

liangx@mskcc.org

Current Research Interests

Ms. Liang’s primary collaboration is the Women’s Environment, Cancer, and Radiation Epidemiology (WECARE) study group. She has served as an informatics specialist at the coordinating center of the WECARE study since its inception. The WECARE study is a large international 22-center molecular epidemiological study of breast cancer headed by Dr. Bernstein. The primary objective of the study is to investigate gene-environment interactions in the etiology of breast cancer. The study’s aims are to establish a repository of biologic specimens, epidemiologic risk factor information, radiation and treatment records, and to utilize this unique repository in order to investigate the mechanisms and nature of gene-gene and gene-environment interactions that may influence susceptibility to breast cancer. Since 1999, she has been responsible for all aspects of the informatics related activities of the study, namely centralized information system development, data management, database design and implementation, data summaries, statistics and report generation, and web site design and maintenance. She also is currently involved in data analysis of the study.

Ms. Liang is also involved in the Epidemiology of Endometrial Cancer Consortium (E2C2), a NCI-supported consortium led by Dr. Olson. She combines data from many studies for the investigators to obtain precise information on risk in relation to genetic variants in the aromatase gene, which controls the final step in hormone biosynthesis.

Ms. Liang’s research interests lie in the design of centralized information systems for large-scale, multicenter, multidiscipline studies, data modelling, database design, data management and data analysis.

Publications

Selected Publications

  1. Alcohol Intake and Cigarette Smoking and Risk of a Contralateral Breast Cancer: The Women’s Environmental Cancer and Radiation Epidemiology Study. Knight JA, Bernstein L, Largent J, Capanu M, Begg CB, Mellemkjær L, Lynch CF, Malone KE, Reiner AS, Liang X, Haile RW, Boice JD Jr; WECARE Study Collaborative Group, Bernstein JL. Am J Epidemiol. 2009 Feb 11. [PubMed Abstract]

  2. Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium. Setiawan VW, Doherty JA, Shu XO, Akbari MR, Chen C, De Vivo I, Demichele A, Garcia-Closas M, Goodman MT, Haiman CA, Hankinson SE, Henderson BE, Horn-Ross PL, Lacey JV Jr, Le Marchand L, Levine DA, Liang X, Lissowska J, Lurie G, McGrath M, Narod SA, Rebbeck TR, Ursin G, Weiss NS, Xiang YB, Yang HP, Zheng W, Olson SH. Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):242-7. [PubMed Abstract]

  3. Variants in the ATM gene associated with a reduced risk of contralateral breast cancer. Concannon P, Haile RW, Børresen-Dale AL, Rosenstein BS, Gatti RA, Teraoka SN, Diep TA, Jansen L, Atencio DP, Langholz B, Capanu M, Liang X, Begg CB, Thomas DC, Bernstein L, Olsen JH, Malone KE, Lynch CF, Anton-Culver H, Bernstein JL; Women’s Environment, Cancer, and Radiation Epidemiology Study Collaborative Group. Cancer Res. 2008 Aug 15;68(16):6486-91. [PubMed Abstract]

  4. Variation of breast cancer risk among BRCA1/2 carriers. Begg CB, Haile RW, Borg A, Malone KE, Concannon P, Thomas DC, Langholz B, Bernstein L, Olsen JH, Lynch CF, Anton-Culver H, Capanu M, Liang X, Hummer AJ, Sima C, Bernstein JL. JAMA. 2008 Jan 9;299(2):194-201.[PubMed Abstract]