Memorial Hospital Research Laboratories
The Jonathan Peled Lab
Research
Cancer immunotherapy hold tremendous promise, but durable responses in most disease types are achieved in only a minority of patients. For example, allogeneic hematopoietic-cell transplantation (allo-HCT) is a curative treatment for hematological malignancies, but its success is limited by relapse, graft-vs-host disease (GVHD), or infection. We and others have established that GVHD severity and mortality risk after transplantation are in part dependent on the composition of the intestinal microbiota, yet the mechanisms by which this is mediated remain poorly understood. The Peled laboratory seeks to use human specimens and mouse models to understand how the gut microbiome and host immunity regulate one another and how these relationships might be manipulated to improve immunotherapy for patients with cancer.
Research Projects
People
Jonathan Peled, MD, PhD
Physician-scientist
- The Peled lab focuses on cancer immunotherapy.
- MD, PhD, Albert Einstein College of Medicine
- [email protected]
- Email Address
- View physician profile
- Physician profile
Members
Computational Biologist
Administrative Assistant
Senior Research Technician
Lab Affiliations
Achievements
- NHLBI K08
- New Investigator Award from the American Society for Transplantation and Cellular Therapy
- Career Development Award from the Parker Institute for Cancer Immunotherapy