Memorial Hospital Research Laboratories
The Jonathan Peled Lab
Research

Cancer immunotherapy hold tremendous promise, but durable responses in most disease types are achieved in only a minority of patients. For example, allogeneic hematopoietic-cell transplantation (allo-HCT) is a curative treatment for hematological malignancies, but its success is limited by relapse, graft-vs-host disease (GVHD), or infection. We and others have established that GVHD severity and mortality risk after transplantation are in part dependent on the composition of the intestinal microbiota, yet the mechanisms by which this is mediated remain poorly understood. The Peled laboratory seeks to use human specimens and mouse models to understand how the gut microbiome and host immunity regulate one another and how these relationships might be manipulated to improve immunotherapy for patients with cancer.
Research Projects
Publications
Peled JU et al. Microbiota as a predictor of mortality in allogeneic HCT. N Engl J Med. 2020 Feb 27;382(9):822-834. https://pubmed.ncbi.nlm.nih.gov/32101664/
Stein-Thoeringer CK … Peled JU*, van den Brink MRM.* Lactose drives Enterococcus expansion to promote graft-versus-host disease. Science. 2019 Nov 29;366(6469):1143-1149. https://pubmed.ncbi.nlm.nih.gov/31780560/
People

Jonathan Peled, MD, PhD
Physician-scientist
- The Peled lab focuses on cancer immunotherapy.
- [email protected]
- Email Address
- View physician profile
- Physician profile
Members


Computational Biologist

Administrative Assistant

Senior Research Technician
Lab Affiliations
Achievements
- NHLBI K08
- New Investigator Award from the American Society for Transplantation and Cellular Therapy
- Career Development Award from the Parker Institute for Cancer Immunotherapy
Lab News & Events
Upcoming event
HOPP Research Seminar
Memorial Sloan Kettering Cancer Center
Rockefeller Research Laboratories
430 East 67th Street
Room RRL-120
New York, NY 10065
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Get in Touch
-
Lab Head Email