Memorial Hospital Research Laboratories

The Jonathan Peled Lab

Research

Jonathan Peled
Jonathan Peled, MD, PhD
Physician-scientist

Cancer immunotherapy hold tremendous promise, but durable responses in most disease types are achieved in only a minority of patients. For example, allogeneic hematopoietic-cell transplantation (allo-HCT) is a curative treatment for hematological malignancies, but its success is limited by relapse, graft-vs-host disease (GVHD), or infection. We and others have established that GVHD severity and mortality risk after transplantation are in part dependent on the composition of the intestinal microbiota, yet the mechanisms by which this is mediated remain poorly understood. The Peled laboratory seeks to use human specimens and mouse models to understand how the gut microbiome and host immunity regulate one another and how these relationships might be manipulated to improve immunotherapy for patients with cancer.

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Research Projects

Publications

Peled JU et al. Microbiota as a predictor of mortality in allogeneic HCT. N Engl J Med. 2020 Feb 27;382(9):822-834. https://pubmed.ncbi.nlm.nih.gov/32101664/ 

Stein-Thoeringer CK … Peled JU*, van den Brink MRM.* Lactose drives Enterococcus expansion to promote graft-versus-host disease. Science. 2019 Nov 29;366(6469):1143-1149. https://pubmed.ncbi.nlm.nih.gov/31780560/

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People

Jonathan Peled

Jonathan Peled, MD, PhD

Physician-scientist

  • The Peled lab focuses on cancer immunotherapy.
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Email Address
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Members

Cindy Junes

Administrative Assistant

Madhumitha Rangesa

Senior Research Technician

Lab Affiliations

Achievements

  • NHLBI K08
  • New Investigator Award from the American Society for Transplantation and Cellular Therapy
  • Career Development Award from the Parker Institute for Cancer Immunotherapy

Open Positions

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