Memorial Hospital Research Laboratories

The Jonathan Peled Lab


Jonathan Peled
Jonathan Peled, MD, PhD

Cancer immunotherapy hold tremendous promise, but durable responses in most disease types are achieved in only a minority of patients. For example, allogeneic hematopoietic-cell transplantation (allo-HCT) is a curative treatment for hematological malignancies, but its success is limited by relapse, graft-vs-host disease (GVHD), or infection. We and others have established that GVHD severity and mortality risk after transplantation are in part dependent on the composition of the intestinal microbiota, yet the mechanisms by which this is mediated remain poorly understood. The Peled laboratory seeks to use human specimens and mouse models to understand how the gut microbiome and host immunity regulate one another and how these relationships might be manipulated to improve immunotherapy for patients with cancer.

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Research Projects


Peled JU et al. Microbiota as a predictor of mortality in allogeneic HCT. N Engl J Med. 2020 Feb 27;382(9):822-834. 

Stein-Thoeringer CK … Peled JU*, van den Brink MRM.* Lactose drives Enterococcus expansion to promote graft-versus-host disease. Science. 2019 Nov 29;366(6469):1143-1149.

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Jonathan Peled

Jonathan Peled, MD, PhD


  • The Peled lab focuses on cancer immunotherapy.
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Email Address
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Binita Febles
Binita Febles

Computational Biologist

Cindy Junes

Administrative Assistant

Madhumitha Rangesa

Senior Research Technician

Lab Affiliations


  • NHLBI K08
  • New Investigator Award from the American Society for Transplantation and Cellular Therapy
  • Career Development Award from the Parker Institute for Cancer Immunotherapy

Lab News & Events

Upcoming event

HOPP Research Seminar

Memorial Sloan Kettering Cancer Center
Rockefeller Research Laboratories
430 East 67th Street
Room RRL-120
New York, NY 10065

Open Positions

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