Research Labs

The Patel laboratory studies the structural biology of macromolecular recognition, regulation and catalysis. Ongoing projects include structure-function studies of the CRISPR-Cas and cGAS-STING surveillance pathways, on the role of Structure Maintenance Chromosome complexes in mediating DNA double strand break repair, on the role of histone and DNA methylation in epigenetic regulation and on RNA-mediated processes ranging from riboswitches and ribozymes to those governing siRNA and piRNA pathways.

The Pavletich laboratory studies the structural biology of pathways that control cell growth and maintain the integrity of the genome.

The Pertsinidis laboratory uses single-molecule approaches to understand gene transcription and the function of complex macromolecular machines inside live cells.

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.

The Farese & Walther lab studies the biology and pathology of cellular lipid metabolism, focusing on lipid/energy storage in lipid droplets and sphingolipid metabolism in lysosomes.

Xinbo Yang’s lab applies structural biology and protein engineering to decode T cell receptor specificity in cancer and autoimmune disease.