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Physician-scientist Omar Abdel-Wahab studies the functional genomics of hematopoietic malignancies.

… Omar Abdel-Wahab is the Chair of SKI Molecular Pharmacology Program and an Attending Physician on the Leukemia Service in the Department of Medicine at Memorial Sloan Kettering Cancer Center. Omar Abdel-Wahab, MD Chair, Molecular Pharmacology Program, SKI; Evnin Family Chair in Molecular Pharmacology

The Diehl lab studies how the microbiota and other exogenous factors regulate development and function of the intestinal immune system.

… The intestinal immune system faces a number of unique challenges due to continuous exposure to rapidly changing exogenous factors including diet and intestinal microbes. Proper calibration of responses is needed to clear invading pathogens as well as repair damage. Over enthusiastic responses within

Cell biologist Michael Overholtzer studies the mechanisms of tumor initiation and progression, cell adhesion, and cell death.

… The Overholtzer lab studies mechanisms of nutrient sensing and cellular responses to nutrient starvation, including the nutrient recycling pathway autophagy, scavenging pathways such as macropinocytosis, and mechanisms of cell death. We investigate cell death mechanisms that have unique effects on cell

Physician-scientist Prasad S. Adusumilli studies tumor immunology and the development of T-cell‒mediated immunotherapy for thoracic malignancies and pleural-based diseases.

… Research led by Prasad S. Adusumilli focuses on investigation of the tumor immune microenvironment and the development of T-cell‒mediated immunotherapy for thoracic malignancies and pleural-based diseases. His team has championed regional immunotherapy delivery strategies, resulting in translation of

Associate Attending Computer Scientist Harini Veeraraghavan's lab develops and translates new AI and machine learning tools diagnosing and personalizing cancer treatments through automated segmentation of normal tissues and tumors applied to radiation treatment automation, early predicting treatment response and toxicity prediction, and longitudinal tumor treatment response monitoring from medical images.

… Associate Attending Computer Scientist Harini Veeraraghavan’s lab develops and translates new AI and machine learning tools diagnosing and personalizing cancer treatments through automated segmentation of normal tissues and tumors applied to radiation treatment automation, early predicting treatment

Immunology Program Chair Alexander Rudensky focuses on immunological tolerance and the differentiation and function of T cells.

… Our research is focused on understanding the molecular mechanisms governing the differentiation and function of CD4 T lymphocytes and their role in immunity and tolerance.  Major areas of interest include: the molecular and cellular mechanisms governing the differentiation and function of regulatory

Physician-scientist Richard Kolesnick studies the role of ceramide signaling in radiation-induced vascular dysfunction and tumor regression.

… Our laboratory focuses on the role of sphingolipid signaling as a stress response. In this pathway, generation of the second messenger ceramide in response to diverse environmental and pharmacologic stresses (heat, ionizing radiation, ultraviolet light, chemotherapeutic agents, oxidative challenges,

Dr. Jian Carrot-Zhang, PhD, is an Assistant Member in the Computational Oncology Service at MSK. Her research focuses on elucidating germline–somatic interactions across multi-ancestral populations.

… Dr. Jian Carrot-Zhang, PhD, is an Assistant Member in the Computational Oncology Service at MSK. Her research focuses on elucidating germline–somatic interactions across multi-ancestral populations. She develops computational and statistical approaches to characterize germline determinants of cancer

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.

… The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches (including virology, biochemistry, structural biology, and genetics) and applies them to model systems

Lydia Finley studies the mechanisms that link metabolic pathways to cell fate decisions.

… The Finley Lab investigates how cellular metabolic pathways regulate cell fate decisions in stem cells and cancer cells. We combine genetic and metabolomic approaches to investigate cell-type specific growth requirements and elucidate how flux through central metabolic pathways regulates key cellular