I am a board-certified medical oncologist specializing in the care of patients with lung cancer. In addition to serving as Chief of the Thoracic Oncology Service at Memorial Sloan Kettering Cancer Center, I co-chair the Eastern Cooperative Oncology Group Thoracic Committee, and am a member of the National Cancer Institute Thoracic Malignancies Steering Committee.
I direct a broad research program of therapeutic research with the ultimate goal of improving the outcome for patients with lung cancer. My research includes laboratory-based investigations to identify and test novel treatment approaches to lung cancer, early-phase clinical trials to bring these ideas to the clinic, and later-phase studies to establish the efficacy of these new approaches. We are interested in small cell and non-small cell lung cancers. Some of the strategies my group has explored both in the laboratory and in the clinic include turning back on genes silenced in cancer, re-activating cancer cell death pathways, and treating lung cancer with a cancer-specific virus.
- Clinical Expertise: Lung Cancer and Other Thoracic Malignancies; Developmental Therapies
- Languages Spoken: English
- Education: MD, University of Chicago
- Residencies: Internal Medicine - University of Chicago
- Fellowships: Hematology/Oncology - University of Chicago
- Board Certifications: Medical Oncology
Research is integral to our mission at Memorial Sloan Kettering, and clinical trials help us discover better forms of patient care and treatment. For you, this could mean access to a new therapy or therapy combination. Click to see a list of the trials I’m currently leading.
Clinical Trials Led by Charles M. Rudin
- A Phase I Study of SC-002 in Patients with Recurrent or Persistent Small Cell Lung Cancer or Large Cell Neuroendocrine Cancer
- A Phase I Study of the CVA21 Virus plus Pembrolizumab Immunotherapy in Patients with Advanced Non-Small Cell Lung Cancer or Bladder Cancer
- A Phase II Study of Rovalpituzumab Tesirine for Recurrent Small Cell Lung Cancer: the TRINITY Study
Clinical Trials Co-Investigated by Charles M. Rudin
- A Phase I Study of AZD1775 and Olaparib in Patients with Solid Tumors
- A Phase I Study of Immunotherapy with Atezolizumab plus Epacadostat in Patients with Previously Treated Stage IIIB or IV Non-Small Cell Lung Cancer
- A Phase I Study of Immunotherapy with Genetically Engineered T Cells (CAR T Cells) to Treat Mesothelioma and Malignant Pleural Disease from Lung and Breast Cancers
- A Phase IB Study of Atezolizumab Immunotherapy Given with Erlotinib or Alectinib in Patients with Advanced Non-Small Cell Lung Cancer
- A Phase Ib/II Study of Entinostat plus Pembrolizumab Immunotherapy in Patients with Metastatic Non-Small Cell Lung Cancer
- A Phase II/III Study to See if Avoiding the Hippocampus during Whole-Brain Radiation Therapy Prevents Memory and Thinking Problems in People with Small Cell Lung Cancer
- A Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide
- A Phase III Study of Immunotherapy with Nivolumab, Nivolumab/Ipilimumab, or Placebo as Maintenance Therapy in Patients with Extensive-Stage Disease Small Cell Lung Cancer
- A Phase III Study of Lanreotide Autogel/Depot versus Placebo in Patients with Metastatic or Inoperable Lung Neuroendocrine Tumors
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