Bone Cancer Clinical Trials & Research

Doctors at Memorial Sloan Kettering are constantly working to improve treatment for bone cancer patients everywhere. One way we do this is through clinical trials. Participating in a clinical trial may give you access to surgical procedures and other treatments that are not widely available elsewhere. It may also give you additional options if your cancer has returned after standard treatment.

Our scientists are analyzing the genetic changes linked to primary bone cancer to better understand why some bone cancers respond more readily to treatment than others. This knowledge may lead to new therapies for patients.

Our experts can help determine if a clinical trial is right for you. The following clinical trials for bone cancer are currently enrolling new patients. To learn more about a particular study, choose from the list below.

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9 Clinical Trials found
A Phase 1 Study of Lurbinectedin in Children With Solid Tumors
In this study, researchers are assessing the safety of the drug lurbinectedin in young people with solid tumors. In the first part, they will find the highest dose of lurbinectedin to use safely in children with solid tumors. If your child joins, this is the part of the study they will be in.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 1/2 Study of Afamitresgene Autoleucel SPEAR T Cell Therapy in Children and Young Adults With Solid Tumors
Researchers are assessing a new type of therapy in young people with solid tumors that keep growing even after treatment. The therapy is called afamitresgene autoleucel. The people in this study have synovial sarcoma, malignant peripheral nerve sheath tumor (MPNST), neuroblastoma, or osteosarcoma. In addition, they have tested positive for the HLA-A*02 gene and their cancers make a protein called MAGE-A4. This protein plays a role in cancer growth.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 1/2 Study of CBL0137 to Treat Advanced Solid Tumors in Children and Young Adults
Researchers in this study are seeking the best dose of CBL0137 in people with solid tumors. They also want to see how well it works against certain cancers.
New York City
A Phase 1/2 Study of Lurbinectedin to Treat People With FET-Fused Tumors
Researchers in this study want to find the best dose of lurbinectedin to treat cancer in children and adults. They also want to see how well this drug works. The people in this study have Ewing sarcoma or other solid tumors that keep growing after treatment. In addition, their cancers contain a genetic change called a FET fusion.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 2-3 Study Assessing the Addition of Cabozantinib to Chemotherapy in People With Newly Diagnosed Osteosarcoma
Researchers want to see if adding cabozantinib to standard chemotherapy works better than chemotherapy alone for osteosarcoma. The people in this study include children, adolescents, and young adults with osteosarcoma that has not yet been treated.
New York City
A Phase III Study Comparing Two Surgery Methods to Treat Cancer in the Lung in Patients with Bone Cancer
The purpose of this study is to compare two different approaches to surgery for children and adults with osteosarcoma (bone cancer) that has spread (metastasized) to the lungs. Participants will be randomly assigned to one of two techniques:
New York City
A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma
To learn more about the purpose of this study and to find out who can join, please click here to visit ClinicalTrials.gov for a full clinical trial description.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Study of ST-01156 in People With Solid Tumor Cancer
To learn more about the purpose of this study and to find out who can join, please click here to visit ClinicalTrials.gov for a full clinical trial description.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
Expanded Access to L-MTP-PE for the Treatment of Osteosarcoma
This protocol will provide expanded access to treatment with the investigational drug L-MTP-PE for people with osteosarcoma. L-MTP-PE works by activating certain types of white blood cells, and these active white blood cells help the immune system to kill cancer cells. L-MTP-PE is given intravenously (by vein).
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau