Primary Brain Tumor Clinical Trials & Research

VIDEO |

What is a Clinical Trial?

This video explains what clinical trials are and may help you decide if taking part in one is the right choice for you.
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Clinical trials at Memorial Sloan Kettering Cancer Center may give you access to new therapies that aren’t widely available. These research studies evaluate the safety and effectiveness of new ways to diagnose and treat primary brain tumors. They can also give your treatment team information about your current plan of care.

Because doctors from different disciplines work together closely through our collaborative Brain Tumor Center, many of our clinical trials combine different treatment approaches, such as radiation therapy and chemotherapy. These aggressive approaches show promise for improving the treatment of many types of brain tumors.

Our experts can help determine which clinical trial is right for you, including some of our newly opened clinical trials:

As a member of the North American Brain Tumor Coalition, we offer qualified patients access to several clinical trials sponsored by the National Cancer Institute.

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26 Clinical Trials found
The purpose of this study is to evaluate the effectiveness of treating patients with recurrent and newly diagnosed glioblastoma using new therapies that are thought to be effective for treating brain cancer. The new therapies available as part of this clinical trial include regorafenib, VAL-083, and paxalisib.
Researchers want to learn if the radiopharmaceutical therapy 177Lu-PSMA-617 is a safe treatment for people with glioma. Radiopharmaceutical therapy delivers radiation directly into a tumor to destroy cancer cells.
Researchers want to find the best dose of avutometinib to treat children and young adults with advanced solid tumors. The people in this study have cancers that have spread or come back after treatment. In addition, their cancers have a mutation (change or variant) in a protein family called MAPK. These proteins tell cancer cells to grow.
Researchers want to find the best dose of Debio 0123 that can be given with temozolomide to treat glioblastoma. Glioblastoma is a type of brain cancer. The people in this study have glioblastoma that keeps growing even after treatment.
Researchers are finding the best dose of MB-CART19.1 immunotherapy in people with lymphoma. The people in this study have central nervous system lymphoma (CNSL) that came back or keeps growing after treatment.
Researchers are assessing a drug called rQNestin34.5v.2, for people with brain cancer that came back after treatment. The people in this study have a type of brain cancer called a glioma.
Researchers want to find the best dose of ODM-212 to treat advanced solid tumors. The people in this study have solid tumors that have spread and cannot be cured with standard therapies. Examples include:
Researchers want to find the best dose of TNG456 to use alone or with abemaciclib to treat brain cancer. The people in this study have glioblastoma that has spread. In addition, their cancer is missing a protein called MTAP.
Researchers in this study are seeking the best dose of CBL0137 in people with solid tumors. They also want to see how well it works against certain cancers.
This study is assessing ABBV-637 and ABBV-155 with ERAS-801 or standard treatment in people with glioblastoma. The people in this study have newly diagnosed glioblastoma or glioblastoma that returned after treatment and can be surgically removed. In addition, their tumors have a mutation (change) in the EGFR gene.