Multiple Myeloma Clinical Trials & Research

MSK is a major research institution. During your treatment for multiple myeloma, your care team may ask if you want to join a clinical trial.

What is a clinical trial?

Clinical trials are research studies that test new treatments, procedures, or devices to see how well they work. They are an important part of helping to prevent, treat, and cure cancer. Almost every cancer treatment given to patients was first tested during a clinical trial.

MSK tests new treatments for multiple myeloma. In general, treatment trials test new drugs, drug combinations, devices, and ways of doing procedures, surgery, or radiation therapy.

Sometimes a clinical trial gives you access to new therapies that are not yet available at most hospitals. Talk with your doctor about whether joining a clinical trial is right for you.

Clinical trials are designed to answer questions about:

  • Safety
  • Benefits
  • Side effects
  • Whether some people are helped more than others

MSK will start a clinical trial only if our researchers think we can improve methods for cancer:

  • Prevention
  • Treatment
  • Diagnosis
  • Screening

For more information, please read Clinical Trials at MSK: What You Need to Know.

Clinical trials to improve treatments for multiple myeloma

MSK is researching new ways to evaluate people with myeloma just when they’re diagnosed. We aim to evaluate how they may respond to treatment.

MSK researchers are learning more about the genetics of multiple myeloma. We are using this knowledge to find better drugs to control the disease.

We look for changes (mutations and variants) that can make the cancer worse. MSK has a team of experts in using diagnostic tools, such as DNA sequencing or microarray analysis. A microarray is a lab tool that can analyze thousands of genes at one time. 

Through MSK clinical trials, we’re exploring the best ways to combine standard chemotherapy drugs with immune-modifying drugs. We also are testing newer immunotherapies and mechanisms of action (how a drug affects the body).

You can search below for the latest list of MSK’s clinical trials for multiple myeloma and related plasma cell diseases.

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37 Clinical Trials found
Researchers want to see if  dietary changes can affect chemotherapy response or quality of life in people newly diagnosed with multiple myeloma. The people in this study are receiving standard induction (initial) chemotherapy with daratumumab or isatuximab, lenalidomide, bortezomib, and dexamethasone (DRVd).
Researchers want to find the best dose of BMS-986393 to use with other drugs to treat multiple myeloma. The people in this study have multiple myeloma that keeps growing or came back after treatment.
Researchers want to find the best dose of BMS-986453 to treat multiple myeloma. The people in this study have multiple myeloma that came back or keeps growing even after treatment.
Researchers want to find the best dose of CB-011 to treat multiple myeloma. The people in this study have multiple myeloma that keeps growing even after treatment.
Researchers want to find the best dose of iberdomide that can be given with elranatamab in people with multiple myeloma. The people in this study have multiple myeloma that came back or keeps growing even after treatment.
Researchers want to find the best dose of JNJ-79635322 to use in people with multiple myeloma or AL amyloidosis. The people in this study have multiple myeloma or AL amyloidosis that keeps growing even after treatment. Multiple myeloma is a cancer of the bone marrow. AL amyloidosis happens when a protein called amyloid builds up in organs and prevents them from working properly.
Multiple myeloma that keeps growing after treatment can cause cancer cells to build up inside the bones. The cancer cells crowd out healthy blood cells and make abnormal proteins that cause discomfort. Researchers in this study want to find the best dose of KTX-1001 to treat multiple myeloma that grows after treatment.
Researchers are assessing the combination of teclistamab and mezigdomide to treat multiple myeloma. The people in this study have multiple myeloma that came back or keeps growing after treatment.
Researchers want to find the best dose of ABBV-453 to treat multiple myeloma. The people in this study have multiple myeloma that may have a genetic change and make too much of the BCL2 protein. In addition, their cancer has not responded to treatment or has returned after treatment.
Researchers want to see if Tec-RVd after 3 treatment cycles of Dara-RVd is safe for people with multiple myeloma. The people in this study have newly diagnosed multiple myeloma.