Audrey Mauguen, PhD

Assistant Attending Biostatistician

Audrey Mauguen, PhD

Office Phone



ISPED, University of Bordeaux (France)

Current Research Interests:

Dr. Mauguen’s methodological research focuses on survival analyses and the prediction of survival endpoints. She is particularly interested in using information from complex covariates such as recurrent events and biomarker evolution. She also worked on improving the diagnostic and prediction of cancer risk by proposing a strategy to define cancer subtypes. Recently, her interests include analyzing somatic mutations and assessing the clonal relatedness between two tumors from a patient in order to distinguish between metastasis and second primary, a work in close collaboration with colleagues Colin Begg, Venkatraman Seshan and Irina Ostrovnaya. She is collaborating with clinical investigators from the Pediatric Department and from the Molecular Imaging and Therapy Service.


R package frailtypack: General Frailty Models: Shared, Joint and Nested Frailty Models with Prediction (first author: Virginie Rondeau)

R package Clonality: Testing for clonal relatedness versus independence of tumors from the same patient (first author: Irina Ostrovnaya)


Selected peer-reviewed publications:

  1. Mauguen A, Seshan VE, Ostrovnaya I, Begg CB. An EM algorithm to improve the estimation of the probability of clonal relatedness of pairs of tumors in cancer patients. BMC Bioinformatics. 2019 Nov 8;20(1):555. doi: 10.1186/s12859-019-3148-z.
  2. Mauguen A, Seshan VE, Begg CB, Ostrovnaya I. Testing clonal relatedness of two tumors from the same patient based on their mutational profiles: update of the Clonality R package. Bioinformatics. 2019 Nov 1;35(22):4776-4778. doi: 10.1093/bioinformatics/btz486.
  3. Mauguen A, Seshan VE, Ostrovnaya I, Begg CB. Estimating the probability of clonal relatedness of pairs of tumors in cancer patients. Biometrics. 2018 Mar;74(1):321-330. doi: 10.1111/biom.12710.
  4. Mauguen A, Zabor EC, Thomas NE, Berwick M, Seshan VE, Begg CB. Defining Cancer Subtypes With Distinctive Etiologic Profiles: An Application to the Epidemiology of Melanoma. J Am Stat Assoc. 2017;112(517):54-63. doi: 10.1080/01621459.2016.1191499.
  5. Mauguen A, Rachet B, Mathoulin-Pélissier S, MacGrogan G, Laurent A, Rondeau V. Dynamic prediction of risk of death using history of cancer recurrences in joint frailty models. Stat Med. 2013 Dec 30;32(30):5366-80. doi: 10.1002/sim.5980.

View a full listing of Audrey Mauguen’s journal articles.


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Audrey Mauguen discloses the following relationships and financial interests:

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