Dr. Mauguen’s methodological research focuses on survival analyses and the prediction of survival endpoints. She is particularly interested in using information from complex covariates such as recurrent events and biomarker evolution. She also worked on improving the diagnostic and prediction of cancer risk by proposing a strategy to define cancer subtypes. Recently, her interests include analyzing somatic mutations and assessing the clonal relatedness between two tumors from a patient in order to distinguish between metastasis and second primary, a work in close collaboration with colleagues Colin Begg, Venkatraman Seshan and Irina Ostrovnaya. She is collaborating with clinical investigators from the Pediatric Department and from the Molecular Imaging and Therapy Service.
R package frailtypack: General Frailty Models: Shared, Joint and Nested Frailty Models with Prediction
R package Clonality: Testing for clonal relatedness versus independence of tumors from the same patient (first author: Irina Ostrovnaya)