Irina Ostrovnaya, PhD

Associate Attending Biostatistician

Irina Ostrovnaya, Associate Attending Biostatistician

Office Phone



University of Chicago

Current Research Interests

Dr. Ostrovnaya is interested in statistical methods in cancer genomics. One of her recent projects involves developing methodology for distinguishing second primary tumors from metastases using point mutations, copy number or next generation sequencing data. Other interests include developing new methods for investigating tumor heterogeneity and prognostic modeling using high throughput molecular data. Dr. Ostrovnaya is a biostatistician for the neuroblastoma and bladder cancer oncology groups.


Selected peer-reviewed publications:

  1. Mauguen A, Seshan VE, Ostrovnaya I, Begg CB. “‘Estimating the probability of clonal relatedness of pairs of tumors in cancer patients.”’, Biometrics. 2017 May 8. doi: 10.1111/biom.12710. [Epub ahead of print] PMID: 28482133

  2. Devlin SM, Ostrovnaya I, Gonen M. “‘Boomerang: A method for recursive reclassification”’, Biometrics. 2016 Jan 11. doi: 10.1111/biom.12469.

  3. Ostrovnaya I, Seshan B and Begg CB, “‘Using Somatic Mutation Data To Test Tumors For Clonal Relatedness”’, Ann Appl Stat. 2015 Sep;9(3):1533-1548. Epub 2015 Nov 2. PMID: 26594266

  4. Ostrovnaya I., Nicolae D.L. “Estimating the proportion of true null hypotheses under dependence”, Statistica Sinica, 2012 (22), 1689-1716

  5. Ostrovnaya I., Seshan V E, Olshen A. and Begg C.B. “Clonality: an R package for testing clonal relatedness of two tumors from the same patient based on their genomic profiles”, Bioinformatics, 2011 Jun 15;27(12):1698-9.

For a complete list of publications: