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Mengmeng (Margaret) Du, ScD

Assistant Attending Epidemiologist

Mengmeng (Margaret) Du, Assistant Attending Epidemiologist

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Harvard University

Dr. Du’s research aims to identify genetic and modifiable predictors of colorectal and endometrial cancers, with the goal of better understanding tumorigenesis and informing improved preventive strategies. She is an active investigator in the Genetics and Epidemiology of Colorectal Cancer Consortium, a large collaborative effort including over 40,000 participants. Together with researchers from North America, Australia, and Europe, she studies the interplay of genes and environment (e.g., anthropometrics, lifestyle, diet, and medication use) in colorectal cancer. She is also active in the Epidemiology of Endometrial Cancer Consortium, a collaborative effort including over 45 population-based studies, where she and colleagues are studying diabetes, obesity, and hypertension in the development of endometrial cancer. In addition to her consortia work, Dr. Du studies telomere dynamics and their role in cancer in the Nurses’ Health Study, a large nationwide cohort of women’s health. She is also collaborating with MSK colleagues in the Global Cancer Disparity Initiatives program to form a hospital-based case-control study investigating cancer determinants in sub-Saharan Africa.


Selected peer-reviewed publications:

  1. Du M, Jiao S (joint lead author), Rosse SA, Abecasis G, Berndt SI, Bézieau S, Brenner H, Butterbach K, Caan BJ, Carlson C, Casey G, Chan AT, Chang-Claude J, Conti D, Curtis K, Duggan D, Haile R, Harrison TA, Hayes RB, Hoffmeister M, Hopper JL, Hsu L, Hudson T, Jenkins MA, Kury S, Leal SM, Le Marchand L, Lindor N, Newcomb PA, Nickerson D, Potter JD, Schoen RE, Schumacher F, Seminara D, Sattery ML, White E, Peters U, Colon Cancer Family Registry, Genetics and Epidemiology of Colorectal Cancer Consortium. Fine-mapping of common genetic variants associated with colorectal tumor risk identified potential functional variants. PLoS One. 2016;11(7):e0157521.

  2. Du M, Auer PL (joint lead author), Jiao S, Haessler J, Altshuler D, Boerwinkle E, Carlson CS, Carty CL, Chen YI, Curtis K, Franceschini N, Hsu L, Jackson R, Lange LA, Lettre G, Monda KL; National Heart, Lung, and Blood Institute (NHLBI) Go Exome Sequencing Project; Nickerson DA, Reiner AP, Rich SS, Rosse SA, Rotter JI, Willer CJ, Wilson JG, North K, Kooperberg C, Heard-Costa N, Peters U. Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans. Hum Mol Genet. 2014;23(24):6607-15.

  3. Du M, Zhang X, Hoffmeister M, Schoen RE, Baron JA, Berndt SI, Brenner H, Carlson CS, Casey G, Chan AT, Curtis KR, Duggan D, Gauderman WJ, Giovannuci EL, Gong J, Harrison TA, Hayes RB, Henderson BE, Hopper JL, Hsu L, Hudson TJ, Hutter CM, Jenkins MA, Jiao S, Kocarnik J, Kolonel LN, Le Marchand L, Lin Y, Newcomb PA, Rudolph A, Seminara D, Thornquist M, Ulrich CM, White E, Wu K, Zanke BW, Campbell PT, Slattery ML, Peters U, Chang-Claude J, Potter JD. No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2014;23(12):2971-6.

  4. Du M, Kraft P, Eliassen AH, Giovannucci E, Hankinson SE, De Vivo I. Physical activity and risk of endometrial cancer in the Nurses’ Health Study. Int J Cancer. 2014;134(11):2707-16.

  5. Nan H, Du M (joint lead author), De Vivo I, Manson JE, Liu S, McTiernan A, Curb JD, Lessin LS, Bonner MR, Guo Q, Qureshi AA, Hunter DJ, Han J. Shorter telomeres associate with a reduced risk of melanoma development. Cancer Res. 2011;71(21):6758-63.

For a complete list of publications: