Mengmeng (Margaret) Du, ScD

Assistant Attending Epidemiologist

Office Phone

646-888-8123

Email

dumeng@mskcc.org

Education

Harvard University

Dr. Du’s research aims to identify genetic and modifiable predictors of colorectal and endometrial cancers, with the goal of better understanding tumorigenesis and informing improved preventive strategies. She is an active investigator in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), a large collaborative effort including data from over 40,000 participants. Together with researchers from North America, Australia, and Europe, she studies the interplay of genes and environment (e.g., anthropometrics, lifestyle, diet, and medication use) in colorectal cancer. She is also active in the Epidemiology of Endometrial Cancer Consortium (E2C2), a collaborative effort including data from over 45 population-based studies, where she and colleagues are studying diabetes, obesity, and hypertension in the development of endometrial cancer. Beyond cancers, Dr. Du seeks to understand telomere length dynamics—a potential indicator of cellular aging linked to chronic disease—along with their role in cancer. She is carrying out much of these investigations in the Nurses’ Health Study (NHS), a large nationwide cohort of women’s health.

Publications

GIANT consortium (Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, et al. including Du M). Rare and low-frequency coding variants alter human adult height. Nature. In Press.

Kantor ED, Rehm CD, Du M, White E, Giovannucci EL. Trends in dietary supplement use among US adults from 1999-2012. JAMA. 2016;316(14):1464-1474.

Li X, Liang G, Du M, De Vivo I, Nan H. No association between telomere length-related loci and number of cutaneous nevi. Oncotarget. 2016. doi: 10.18632/oncotarget.12021.

Gong J, Hutter CM, Newcomb PA, Ulrich CM, Campbell PT, Baron JA, Berndt SI, Bezieau S, Brenner H, Casey G, Chan AT, Chang-Claude J, Du M, Duggan D, Figueiredo JC, Gallinger S, Giovannucci EL, Haile RW, Harrison TA, Bayes RB, Hoffmeister M, Hopper JL, Hudson TJ, Jenkins MA, Kocarnik J, Küry S, Le Marchand, L, Lin Y, Lindor NM, Nishihara R, Ogino S, Potter JD, Rosse SA, Rudolph A, Schoen RE, Schrotz-King P, Seminara D, Slattery ML, Thibodeau SN, Thornquist M, Toth R, Wallace R, White E, Jiao S, Lemire M, Hsu L, Peters U, CCFR, GECCO. Genome-wide interaction analyses between genetic variants and alcohol consumption and smoking for risk of colorectal cancer. PLoS Genetics. 2016;12(10):e1006296.

Du M, Jiao S (joint lead author), Rosse SA, Abecasis G, Berndt SI, Bézieau S, Brenner H, Butterbach K, Caan BJ, Carlson C, Casey G, Chan AT, Chang-Claude J, Conti D, Curtis K, Duggan D, Haile R, Harrison TA, Hayes RB, Hoffmeister M, Hopper JL, Hsu L, Hudson T, Jenkins MA, Kury S, Leal SM, Le Marchand L, Lindor N, Newcomb PA, Nickerson D, Potter JD, Schoen RE, Schumacher F, Seminara D, Sattery ML, White E, Peters U, Colon Cancer Family Registry, Genetics and Epidemiology of Colorectal Cancer Consortium. Fine-mapping of common genetic variants associated with colorectal tumor risk identified potential functional variants. PLoS One. 2016;11(7):e0157521.

Garcia-Albeniz X, Rudolph A, Hutter C, White E, Lin Y, et al. (including Du M). Rosse SA, Figueiredo JC, Harrison TA, Jiao S, Brenner H, Casey G, Hudson TJ, Thornquist M, Le Marchand L, Potter J, Slattery ML, Zanke B, Baron JA, Caan BJ, Chanock SJ, Berndt SI, Stelling D, Fuchs CS, Hoffmeister M, Butterbach K, Du M, James Gauderman W, Gunter MJ, Lemire M, Ogino S, Lin J, Hayes RB, Haile RW, Schoen RE, Warnick GS, Jenkins MA, Thibodeau SN, Schumacher FR, Lindor NM, Kolonel LN, Hopper JL, Gong J, Seminara D, Pflugeisen BM, Ulrich CM, Qu C, Duggan D, Cotterchio M, Campbell PT, Carlson CS, Newcomb PA, Giovannucci E, Hsu L, Chan AT, Peters U, Chang-Claude J. CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk. Br J Cancer. 2016;114(2):221-9.

Lemire M, Qu C, Loo LWM, Zaidi SHE, Wang H, Berndt SI, Bezieau S, Brenner H, Campbell PT, Chan AT, Chang-Claude J, Du M, Edlund CK, Gallinger S, Haile RW, Harrison TA, Hoffmeister M, Hopper JL, Hou L, Hsu L, Jacobs EJ, Jenkins MA, Jeon J, Küry S, Li L, Lindor NM, Newcomb PA, Potter JD, Rennert G, Rudolph A, Schoen RE, Schumacher FR, Seminara D, Severi G, Slattery ML, White E, Woods MO, Cotterchio M, Le Marchand L, Casey G, Gruber SB, Peters U, Hudson TJ. A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1. Hum Genet. 2015;134(11-12):1249-62.

Thrift AP, Gong J, Peters U, Chang-Claude J, Rudolph A, Slattery ML, Chan AT, Esko T, Wood AR, Yang J, Vedantam S, Gustafsson S, Tune P, GIANT Consortium, Baron JA, Bezieau S, Küry S, Ogino S, Berndt SI, Casey G, Haile RW, Du M, Harrison TA, Thornquist M, Duggan DJ, Le Marchand L, Lemire M, Lindor NM, Seminara D, Song M, Thibodeau SN, Cotterchio M, Win AK, Jenkins MA, Hopper JL, Ulrich CM, Potter JD, Newcomb PA, Schoen RE, Hoffmeister M, Brenner H, White E, Hsu L, Campbell PT. Mendelian randomization study of height and risk of colorectal cancer. Int J Epidemiol. 2015;44(2):662-72.

Thrift AP, Gong J, Peters U, Chang-Claude J, Rudolph A, Slattery ML, Chan AT, Locke AE, Kahali B, Justice AE, Pers TH, GIANT Consortium, Gallinger S, Hayes RB, Baron JA, Caan BJ, Ogino S, Berndt SI, Chanock SJ, Casey G, Haile RW, Du M, Harrison TA, Thornquist M, Duggan DJ, Le Marchand L, Lindor NM, Seminara D, Song M, Wu K, Thibodeau SN, Cotterchio M, Win AK, Jenkins MA, Hopper JL, Ulrich CM, Potter JD, Newcomb PA, Hoffmeister M, Brenner H, White E, Hsu L, Campbell PT. Mendelian randomization study of body mass index and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2015;24(7):1024-31.

Hsu L, Jeon J, Brenner H, Gruber SB, Schoen RE, Berndt SI, Chan AT, Chang-Claude J, Du M, Gong J, Harrison TA, Hayes RB, Hoffmeister M, Hutter CM,  Lin Y, Nishihara R, Ogino S, Prentice RL, Schumacher FR, Seminara D, Slattery ML, Thomas DC, Thornquist M, Newcomb PA, Potter JD, Zheng Y, White E, Peters U on behalf of the Colorectal Transdisciplinary (CORECT) Study and Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). A Predictive Model of Colorectal Cancer Risk Using Common Genetic Susceptibility Loci. Gastroenterology. 2015;148(7):1330-1339.e14.

Ananthakrishnan AN, Du M, Berndt SI, Brenner H, Caan BJ, Casey G, Chang-Claude J, Duggan D, Fuchs CS, Gallinger S, Giovannucci EL, Harrison TA, Hayes RB, Hoffmeister M, Hopper JL, Hou L, Hsu L, Jenkins MA, Kraft P, Ma J, Nan H, Newcomb PA, Ogino S, Potter JD, Seminara D, Slattery ML, Thornquist M, White E, Wu K, Peters U, Chan AT. Red meat intake, NAT2, and risk of colorectal cancer: A pooled analysis of 11 studies. Cancer Epidemiol Biomarkers Prev. 2015;24(1):198-205.

Thyfault JP, Du M, Kraus WE, Levine JA, Booth FW. Physiology of sedentary behavior and its relationship to health outcomes. Med Sci Sports Exerc. 2015;47(6):1301-5.

Crous-Bou M, Fung TT, Prescott J, Julin B, Du M, Sun Q, Rexrode KM, Hu F, De Vivo I. Mediterranean diet is associated with longer telomere length in the Nurses’ Health Study. BMJ. 2014;349:g6674.

Du M, Zhang X, Hoffmeister M, Schoen RE, Baron JA, Berndt SI, Brenner H, Carlson CS, Casey G, Chan AT, Curtis KR, Duggan D, Gauderman WJ, Giovannuci EL, Gong J, Harrison TA, Hayes RB, Henderson BE, Hopper JL, Hsu L, Hudson TJ, Hutter CM, Jenkins MA, Jiao S, Kocarnik J, Kolonel LN, Le Marchand L, Lin Y, Newcomb PA, Rudolph A, Seminara D, Thornquist M, Ulrich CM, White E, Wu K, Zanke BW, Campbell PT, Slattery ML, Peters U, Chang-Claude J, Potter JD. No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2014;23(12):2971-6.

Du M, Auer PL (joint lead author), Jiao S, Haessler J, Altshuler D, Boerwinkle E, Carlson CS, Carty CL, Chen YI, Curtis K, Franceschini N, Hsu L, Jackson R, Lange LA, Lettre G, Monda KL; National Heart, Lung, and Blood Institute (NHLBI) Go Exome Sequencing Project; Nickerson DA, Reiner AP, Rich SS, Rosse SA, Rotter JI, Willer CJ, Wilson JG, North K, Kooperberg C, Heard-Costa N, Peters U. Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans. Hum Mol Genet. 2014;23(24):6607-15.

Kantor ED, Hutter CM, Minnier J, Berndt SI, Brenner H, Caan BJ, Campbell PT, Carlson CS, Casey G, Chan AT, Chang-Claude J, Chanock SJ, Cotterchio M, Du M, Duggan D, Fuchs CS, Giovannucci EL,Gong J, Harrison TA, Hayes RB, Henderson BE, Hoffmeister M, Hopper JL, Jenkins MA, Jiao S, Kolonel LN, Le Marchand L, Lemire M, Li Y, Ma J, Newcomb PA, Ochs-Balcom HM, Pflugeisen BM, Potter JD, Rudolph A, Schoen RE, Seminara D, Slattery ML, Stelling DL, Thomas F, Thornquist M, Ulrich CM, Warnick GS, Zanke BW, Hsu L, Peters U, White E. Gene-environment interaction involving recently identified colorectal cancer susceptibility loci. Cancer Epidemiol Biomarkers Prev. 2014;23(9):1824-33.

Du M, Kraft P, Eliassen AH, Giovannucci E, Hankinson SE, De Vivo I. Physical activity and risk of endometrial cancer in the Nurses’ Health Study. Int J Cancer. 2014;134(11):2707-16.

Du M, Prescott J, Cornelis MC, Hankinson SE, Giovannucci E, Kraft P, De Vivo I. Genetic predisposition to higher body mass index or type 2 diabetes and leukocyte telomere length in the Nurses’ Health study. PLoS One. 2013;8(2):e52240.

Prescott J, Du M, Wong JYY, Han J, De Vivo I. Paternal age at birth is associated with offspring leukocyte telomere length in the Nurses’ Health Study. Hum Reprod. 2012;27(12):3622-31.

Du M, Prescott J, Kraft P, Han J, Giovannucci E, Hankinson SE, De Vivo I. Physical activity, sedentary behavior, and leukocyte telomere length in women. Am J Epidemiol. 2012;175(5):414 22.

Nan H, Du M (joint lead author), De Vivo I, Manson JE, Liu S, McTiernan A, Curb JD, Lessin LS, Bonner MR, Guo Q, Qureshi AA, Hunter DJ, Han J. Shorter telomeres associate with a reduced risk of melanoma development. Cancer Res. 2011;71(21):6758-63.