Dr. Du studies inherited and modifiable factors in cancer—particularly colorectal, endometrial, and pancreatic cancers. This work, conducted with international research teams, seeks to understand tumorigenesis and identify individuals who could most benefit from targeted lifestyle modifications or preventive interventions. Dr. Du studies colorectal cancer biology, risk factors, and risk modeling: She co-leads an NIH-funded study in the African Research Group in Oncology (ARGO) of risk factors and tumor mutation profiles for colorectal cancers in Nigeria. She also studies colorectal cancer in European descent individuals using data in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Dr. Du investigates endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium (E2C2), for which she is PI of the Data Coordinating Center and member of the Executive Committee. She co-leads an NIH-funded study in this population using multiethnic tumor profiling to shed light on the 2-fold higher mortality in Black patients. Dr. Du also studies pancreatic cancer early detection and risk factor identification: She is PI of the MSK Pancreatic Tumor Registry—which since 2002 has continuously performed surveillance and followed at-risk unaffected relatives of pancreatic cancer patients. To support risk factor studies, the Registry additionally includes patients with pancreatic cancer or with intraductal papillary mucinous neoplasms (IPMNs) and cancer-free controls. Finally, Dr. Du studies telomere dynamics in various large, population-based data sources. She co-directs the MSK Quantitative Sciences Summer Undergraduate Research Experience (QSURE), serves on the Scientific Committee for the New York City Epidemiology Forum, and is an Associate Editor for the international journal Cancer Causes & Control.
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Mengmeng (Margaret) Du discloses the following relationships and financial interests:
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