Xiang Shu

Assistant Attending

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Xiang Shu

Dr. Shu’s research primarily focus on identifying novel genetic and molecular markers for cancer risk, with the goal of better understanding cancer etiology and developing novel tools for risk assessment. He actively participates in multiple international consortia including the Breast Cancer Association Consortium, the Genetics and Epidemiology of Colorectal Cancer Consortium, the Asia Breast Cancer Consortium, and the Asia Colorectal Cancer Consortium, etc. Dr. Shu are leading multiple projects integrating genetic information with omics data in these consortia. Dr. Shu is also an investigator in three large prospective cohorts, the Shanghai Women’s Health Study, the Shanghai Men’s Health Study, and the Southern Community Cohort Study. He has been leading/involved in multiple research projects in these cohorts to search for novel risk biomarkers for colorectal, pancreatic, gastric, gallbladder, and ovarian cancer using metabolomics and proteomics. By examining the potential mediating effects of metabolites and proteins, new knowledge will be gained on how modifiable factors such as diet and exercise affect cancer risk.

Publications

  1. Shu X, Long J, Cai Q, Kweon SS, Choi JY, Kubo M, Park SK, Humphreys M, Dennis J, Wang Q, Yang Y, Shi J, Guo X, Li B, Tao R, Aronson K, Chan K, Chan T, Gao Y, Hartman M, Ho WK, Ito H, Iwasaki M, Iwata H, John E, Kasuga Y, Khoo US, Kim MK, Kong SY, Kurian A, Kwong A, Lee ES, Li J, Lophatananon A, Low S-K, Mariapun S, Matsuda K, Matsuo K, Muir K, Noh DY, Park B, Park MH,  Shen CY, Shin MH, Spinelli J, Takahashi A, Tseng C, Tsugane S, Wu A, Xiang YB, Yamaji T, Zheng Y, Milne R, Dunning A, Pharoah P, Garcia-Closas M, Teo SH, Shu XO, Kang D, Easton D, Simard J. Zheng W. Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants. Nat Commun. 2020 Mar 5;11(1):1217
  2. Shu X, Bao J, Wu L, Long J, Shu XO, Guo X, Yang Y, Michailidou K, Bolla MK, Wang Q, Dennis J, Andrulis IL, Castelao JE, Dörk T, Gago-Dominguez M, García-Closas M, Giles GG, Lophatananon A, Muir K, Olsson H, Rennert G, Saloustros E, Scott RJ, Southey MC, Pharoah PDP, Milne RL, Kraft P, Simard J, Easton DF, Zheng W. Evaluation of associations between genetically predicted circulating protein biomarkers and breast cancer risk. Int J Cancer. 2020 Apr 15;146(8):2130-2138
  3. Wang F, Shu X, Meszoely I, Pal T, Mayer IA, Yu Z, Zheng W, Bailey CE, Shu XO. Overall Mortality After Diagnosis of Breast Cancer in Men vs Women. JAMA Oncol. 2020;6(3):442.
  4. Shu X, Wu L, Khankari NK, Shu XO, Wang TJ, Michailidou K, Bolla MK, Wang Q, Dennis J, Milne RL, Schmidt MK, Pharoah PDP, Andrulis IL, Hunter DJ, Simard J, Easton DF, Zheng W, Breast Cancer Association Consortium. Associations of obesity and circulating insulin and glucose with breast cancer risk: A Mendelian randomization analysis. Int J Epidemiol. 2019 Jun 1;48(3):795-806
  5. Shu X, Xiang YB, Rothman N, Yu D, Li HL, Yang G, Cai H, Ma X, Lan Q, Gao YT, Jia W, Shu XO, Zheng W. Prospective study of blood metabolites associated with colorectal cancer risk. Int J Cancer. 2018 Aug 1;143(3):527-534