Research Labs

Cancer biologist Hans-Guido Wendel pursues both disease-centered and basic discovery research. The disease focus is on lymphocyte malignancies and the basic science arm of the lab explores fundamental mechanisms that control aberrant mRNA translation programs in cancer. Work in these two research areas frequently intersects in surprising ways.

Molecular biologist Iestyn Whitehouse investigates chromatin structure and the function of ATP-dependent chromatin remodelling enzymes.

The Widman Lab within the Digital Oncology Program at MSKCC is using machine learning and genomics to engineer the next-generation of ultrasensitive, highly scalable liquid biopsies for early cancer detection, treatment monitoring, and detection of minimal residual disease (MRD) after surgery for early-stage cancer.

The Wilkinson laboratory studies reverse transcriptases and retrotransposons using biochemistry, structural biology, and genome mining.

Physician-scientist Richard Wong studies the mechanisms of cancer cell chemotaxis in perineural invasion.

Systems biologist Joao Xavier combines experimental and computational approaches to study diverse problems relevant to cancer: how the microbiome influences cancer and cancer treatment, how cancer cells metastasize, and how metabolic fluxes command the behavior of living cells.

My laboratory and clinical research focus on understanding genomics and signaling in colorectal cancer to develop new treatments for patients.

Xinbo Yang’s lab applies structural biology and protein engineering to decode T cell receptor specificity in cancer and autoimmune disease.

The Zallen laboratory focuses on the generation of tissue structure through the collective action of cell populations.

Molecular biologist Xiaolan Zhao studies chromosomal organization, genome integrity, DNA replication and repair, dynamic protein modification.