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The Diehl lab studies how the microbiota and other exogenous factors regulate development and function of the intestinal immune system.

… The intestinal immune system faces a number of unique challenges due to continuous exposure to rapidly changing exogenous factors including diet and intestinal microbes. Proper calibration of responses is needed to clear invading pathogens as well as repair damage. Over enthusiastic responses within

Physician-scientist Andrew Intlekofer investigates why cancer cells depend on specific pathways of nutrient metabolism.

… Andrew Intlekofer is an Assistant Member in the Human Oncology and Pathogenesis Program and an Attending Physician on the Lymphoma Service in the Department of Medicine. Dr. Intlekofer’s research investigates how deregulated metabolic pathways contribute to cancer development and how metabolic enzymes

Cell biologist Philipp Niethammer investigates tissue damage responses with advanced imaging approaches in zebrafish.

… Interdisciplinary approaches to wound healing, inflammation and regeneration. Philipp Niethammer, PhD Professor PhD, European Molecular Biology Laboratories & Hamburg University, Germany Achievements Dorsett L. Spurgeon Distinguished Research Award (2009) Louis Gerstner Young Investigator (2012) American

Immunology Program Chair Alexander Rudensky focuses on immunological tolerance and the differentiation and function of T cells.

… Our research is focused on understanding the molecular mechanisms governing the differentiation and function of CD4 T lymphocytes and their role in immunity and tolerance.  Major areas of interest include: the molecular and cellular mechanisms governing the differentiation and function of regulatory

The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions.

… The goal of my research is to understand the mechanisms and structures of enzymes that perform and regulate essential nucleic acid transactions. My research integrates diverse experimental approaches (including virology, biochemistry, structural biology, and genetics) and applies them to model systems

Lydia Finley studies the mechanisms that link metabolic pathways to cell fate decisions.

… The Finley Lab investigates how cellular metabolic pathways regulate cell fate decisions in stem cells and cancer cells. We combine genetic and metabolomic approaches to investigate cell-type specific growth requirements and elucidate how flux through central metabolic pathways regulates key cellular

The Jasin laboratory focuses on double-strand break repair and genomic integrity in mammalian cells and the relationship to tumor suppression.

… Human chromosomes are constantly assaulted by challenges to their integrity as a result of either environmental agents that damage DNA or from normal DNA metabolism. The failure to repair damaged DNA faithfully is ultimately responsible for many human diseases, especially cancer. This laboratory focuses

Heeseon An’s lab studies protein degradation in health and disease using chemical, biological, and proteomics tools.

… The research in An lab centers around protein degradation processes in health and disease. We use chemical biology tools and unbiased proteomic approaches to discover previously unknown degradational pathways and molecular mechanisms. Specific research areas include 1) developing innovative chemical,

Mechanisms of genetic and epigenetic cooperativity which drive myeloid transformation; Elucidating and modeling evolution from hematopoietic stem/progenitor cells to clonal hematopoiesis and then to myeloid malignancies; Identification and credentialing novel therapeutic dependencies in myeloid malignancies

… The goal of our research is to improve our understanding of the genetic basis of blood disorders known as myeloid malignancies, and to use this knowledge to improve therapies for patients with these disorders. Our efforts are focused on the identification and characterization of somatic mutations in

Physician-scientist Tobias Hohl studies the molecular pathogenesis of human fungal pathogens and how the immune system responds to them.

… The focus of my research program is to decipher the molecular and cellular basis of immunity against Candida and Aspergillus species , major causative agents of invasive mycoses in patients with cancer. We have developed fluorescence-based reporters of fungal physiology to examine the outcome of fungal