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Human Oncology and Pathogenesis Program Chair Charles Sawyers develops molecularly targeted cancer therapy.

… Dr. Sawyers is an HHMI Investigator searching for molecularly targeted approaches to treat cancer. He has identified cell signaling components critical to the growth of cancer cells in chronic myeloid leukemia, prostate and other cancers, resulting in the development of multiple FDA-approved inhibitors

The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development.

… The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development. During development, cells differentiate into various cell types with distinct functions. To understand how different cell types are made, we need a tool to observe cells’ previous and current states, as well

Physician-scientist Vladimir Ponomarev focuses on developing reporter genetic systems for specific applications such as sequential in vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences.

… I am a physician-scientist who focuses on the development of new multi-modal imaging approaches for specific applications, such as sequential in vivo imaging studies in cancer biology, cancer immunotherapy, and radiation sciences. Vladimir Ponomarev, MD, PhD Office phone 646-888-2213

Physician-scientist David Solit studies human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.

… Our research is based on the underlying hypothesis that the ability to inhibit an oncogenic pathway and block cancer growth will vary based on cell lineage and the complement of mutations within the tumor. To design rational therapeutic studies, we must define not only the spectrum of genetic changes

Cell biologist Marilyn Resh investigates the regulation of protein function by fatty acylation, and the development of Hedgehog palmitoylation inhibitors to block pancreatic and lung cancer.

… The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins. Marilyn Resh, PhD Member PhD, Harvard University AB, Princeton

Physician-scientist David R. Jones studies molecular mechanisms governing the development of metastases in lung and esophageal cancers.

… The primary reason people die from cancer is the development of metastatic disease. As a surgeon-scientist who cares for patients with earlier stage lung and esophageal cancer, my laboratory studies why patients with completely resected cancer still develop metastases and die. We focus on a class of

Systems biologist Joao Xavier combines experimental and computational approaches to study diverse problems relevant to cancer: how the microbiome influences cancer and cancer treatment, how cancer cells metastasize, and how metabolic fluxes command the behavior of living cells.

… We combine computation and experiment to investigate how cells interact with each other to produce complex cell group behaviors. Joao Xavier, PhD Member, Computational & Systems Biology Program Professor PhD, Universidade Nova de Lisboa Achievements Director's New Innovator Award, National Institutes

Physician-scientist Christine Iacobuzio-Donahue studies the genomics and cell biology of pancreatic and other solid tumors as it relates to subclonal evolution, tumor progression, and metastasis.

… Our lab investigates the fundamental evolutionary mechanisms underlying metastasis using pancreatic cancer as our model tumor type. Metastasis is the result of a series of biological hurdles subject to Darwinian selection including the birth of metastasis-enabled cells within a heterogeneous primary

The Wilkinson laboratory studies reverse transcriptases and retrotransposons using biochemistry, structural biology, and genome mining.

… Genetic information typically flows in one direction: from DNA to RNA to protein. Our lab is fascinated by reverse transcription, where this flow is flipped on its head, allowing RNA to be rewritten back into DNA. Reverse transcriptases are famously used by retroviruses like HIV to invade genomes, but

The Pavletich laboratory studies the structural biology of pathways that control cell growth and maintain the integrity of the genome.

… Our research group is interested in understanding, at the structural and mechanistic levels, the maintenance of genomic integrity and the control of cell growth, both of which figure prominently in cancer. In the area of growth control, our recent work is focused on the mTOR pathway that controls multiple