Search

Molecular biologist Prasad Jallepalli studies the mechanisms that ensure accurate chromosome transmission in human cells.

… Our laboratory is interested in how human cells accurately duplicate and transmit their chromosomes during each round of division. Prasad Jallepalli, MD, PhD Member Professor MD, PhD, Johns Hopkins University School of Medicine Achievements Phi Beta Kappa, Harvard University (1992) M.D./Ph.D. Fellow,

Molecular biologist Iestyn Whitehouse investigates chromatin structure and the function of ATP-dependent chromatin remodelling enzymes.

… The Whitehouse lab is broadly interested in understanding how chromatin functions in the regulation of cellular processes such as DNA replication, gene transcription and epigenetics. We focus on understanding basic mechanisms and use a combination of biochemical, molecular biological and genomics approaches

We leverage large-scale unbiased profiling including genomics, transcriptomics, proteomics to identify candidate oncogenes and proteins that are pathogenetically relevant in lymphoma.

… Kojo S. Elenitoba-Johnson is the Chair of the Department of Pathology and Laboratory Medicine and a physician-scientist. Dr. Elenitoba-Johnson’s research focuses on the role of genomic and proteomic alterations in the pathogenesis of lymphomas. Dr. Megan S. Lim is the Director of the Lymphoma Translational

The Brown Lab studies how the tissue environment shapes immune cell fate and function during early life immune development, inflammation, and cancer.

… At the Brown Lab, we’re studying how signals from the tissue environment shape the fate and function of immune cells and the mechanisms by which the immune system reciprocally regulates tissue homeostasis and host immunity. At the heart of an immune response are dendritic cells, sentinels of the immune

Physician-scientist James Fagin focuses on the pathogenesis of thyroid cancer and the role of oncogenic kinases.

… The focus of the Fagin lab is to understand the pathogenesis and the biology of thyroid cancers at single cell resolution with the goal of identifying new mechanism-based therapies.  His group has been instrumental in characterizing somatic genetic changes associated with tumor initiation and progression

The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development.

… The Choi Lab develops new synthetic biology tools to study cell-fate decisions in development. During development, cells differentiate into various cell types with distinct functions. To understand how different cell types are made, we need a tool to observe cells’ previous and current states, as well

Cancer biologist Nikolaus Schultz uses computational tools to study the diversity of genomic alterations underlying different cancer types.

… The Schultz lab focuses on identifying the genomic alterations that underlie different types of cancer. By applying existing and novel computational methods to large scale cancer genomics data sets, the lab aims to better understand the complex mechanisms at the gene and at the pathway level that drive

Physician-scientist Karlo Perica develops cell therapies to treat a wide variety of cancers, focusing on off-the-shelf approaches such as allogeneic CAR T cells and in vivo gene editing.

… The laboratory of Dr. Karlo Perica focuses on developing new Chimeric Antigen Receptor T cell and other cell therapies for cancer. We seek to make cell therapy more accessible and more effective by developing “off-the-shelf” approaches using allogeneic cell therapies and in vivo editing. Our research

Jonathan Coleman is a physician-scientist focused on translational research, cancer genomics, and patient-derived organoid models in the study of urologic malignancies. Ongoing work includes the development of local ablative therapies, their influence on the tumor microenvironment, and implications for therapy response.

… Our lab is focused on understanding the mechanism of disease recurrence, response to therapies and disease progression of upper tract urothelial cancer, a rare but aggressive disease. To interrogate molecular diversity of the disease, we employ genomics, transcriptomics, metabolomics and tumor immune

New roles for Notch signaling in the immune system.

… Dr. Maillard’s research focuses on the role of Notch signaling in hematopoiesis as well as in T and B cell development, differentiation and function. Through more than 15 years of research in the field, his laboratory discovered essential functions for Notch receptors and ligands in graft-versus-host