Beta-elemene

Beta-elemene

Beta-elemene

For Patients & Caregivers

Beta-elemene has shown anticancer activity in laboratory studies. More research is needed to study its effects in humans.

Beta-elemene is a compound found in plants such as celery, mint, and in many others used in traditional medicine. Although the pure form is not used as dietary supplement, some cancer patients use herbs high in beta-elemene as treatment. Beta-elemene was shown to prevent growth of cancer cells in laboratory cells by different mechanisms. A few poorly designed studies done in humans showed that it may improve quality of life in cancer patients. It is unclear if raw herbs containing beta-elemene have the same effects in humans. More research is needed.

  • Cancer Treatment
    Laboratory studies indicate that beta-elemene can stop the growth of cancer cells. A few studies have been done in humans but the results are not reliable. Larger, well designed clinical trials are needed.
  • You are undergoing chemotherapy: Beta-elemene may increase the toxicity of chemo drugs, cisplatin and taxanes.
  • You are undergoing radiotherapy: Beta-elemene may increase the adverse effects of radiation.
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For Healthcare Professionals

Ethenyl-1-methyl-2,4-bis(1-methyl ethenyl) cyclohexane

Beta-elemene is a volatile terpene found in celery, mint, and in several other herbs used in traditional medicine. Whereas the purified form is generally not used as a dietary supplement because of poor absorption, many patients consume herbs high in beta-elemene in belief that they help cure cancer.

In vitro studies show anti-proliferative effects of beta-elemene in various cancer cells through cell-cycle arrest and induction of apoptosis (3)(4)(5)(16)(17)(19)(20). It also enhanced the activity of cisplatin against prostate cancer cells (18). The parenteral form of beta-elemene isolated from Rhizoma zedoariae, a species of ginger, has been studied in Asia and is reported to relieve pain, decrease the side effects of chemotherapy, and increase the quality of life in cancer patients. However, human trials conducted so far are of poor quality (1)(15).
A systematic review indicates that beta-elemene injection may improve effectiveness of chemotherapy for the treatment of lung cancer (21). However, controlled trials are needed to confirm this observation.

Rhizoma zedoariae (E Zhu)
Curcuma aromatica (Wenyujin)

  • Cancer Treatment

In an erythroleukemic cell line, beta-elemene inhibited telomerase activity, which was enhanced in combination with cyclophosphamide (9). It also demonstrated anti-fibrotic effects, inducing decreases in plasma angiotensin II levels and angiotensin II receptor type 1 expression, reducing collagen formation in a liver fibrosis rat model (10). Beta-elemene also exhibits anti-inflammatory effects, with reduction in LPS-induced nitric oxide production and prostaglandin E2 by rat peritoneal macrophages (11).

Beta-elemene has been shown to affect cancer cells via different mechanisms. In an in vitro study, following administration of beta-elemene, leukemia cells were arrested in S/G2 phase and underwent apoptosis (2). The antiproliferative effects were dependent on p38 MAPK activation/phosphorylation, cell cycle arrest in G0/G1, and inhibition of tumor growth of glioblastoma cells (3). Beta-elemene also induced G2/M arrest in lung carcinoma cells and ovarian cancer cells by combined reduction of cell-cycle promoters Cdc2 and cyclin B1, and elevated cell cycle regulators p53 and p27 (4)(5). Derivatives of beta-elemene showed antiproliferative activity in human cervical carcinoma cells through a decrease in cell cycle protein Cyclin D1 and thus cell cycle suppression (14). Furthermore, beta-elemene may enhance the effects of chemotherapy and radiation. In non-small cell lung cancer cells, apoptosis was induced by increased expression of Bax and p-Bcl-2, decreased Bcl-2 and XIAP, and augmented cisplatin-induced increases in caspase activity (6). In another study, apoptosis response to the taxanes paclitaxel and docetaxel in lung carcinoma cells was enhanced with beta-elemene, through increases in cytochrome c, caspase activity, downregulation of Bcl-2, and altered cell membrane permeability (7). Beta-elemene combined with radiation induced apoptosis in lung adenocarcinoma cells, possibly by sensitizing cancer cells to radiation (8).
An in vivo study showed that beta-elemene inhibits growth of lung cancer cells, and up-regulates the expression of the tumor suppressor, P53, and the release of exosome (22). Another proposed mechanism is that beta-elemene reverses the resistance of lung cancer cells to cisplatin via the mitochondrial apoptosis pathway (23).

  • Chemotherapy: Beta-elemene may increase the activity of cisplatin and taxanes (6)(7).
  • Radiation: Beta-elemene may increase the effects of radiation (8).

  1. Yao YQ, Ding X, Jia YC, et al. Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett. Jun 8 2008;264(1):127-134.

  2. Hao Jiang SM, Jianguo Feng. In vitro study of radiosensitization by beta-Elemene in A549 cell line from adenocarcinoma of lung. Chinese-German Journal of Clinical Oncology. 2008;8(1):12-15.

  3. Wang Y, Fang MY, Jiang F, Peng HJ. [Effects of arsenic trioxide, ginseng saponin and beta-elemene on telomere-telomerase system in K562 cell line]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. Jun 2004;12(3):315-320.

  4. Zhu R, Yang L, Shen L, et al. ANG II-AT1 receptor pathway is involved in the anti-fibrotic effect of beta-elemene. J Huazhong Univ Sci Technolog Med Sci. Apr 2009;29(2):177-181.

  5. Wang K, Li Z, Chen Y, Su C. The pharmacokinetics of a novel anti-tumor agent, beta-elemene, in Sprague-Dawley rats. Biopharm Drug Dispos. Oct 2005;26(7):301-307.

  6. Xu L, Tao S, Wang X, et al. The synthesis and anti-proliferative effects of beta-elemene derivatives with mTOR inhibition activity. Bioorg Med Chem. Aug 1 2006;14(15):5351-5356.

  7. Rui D, Xiaoyan C, Taixiang W, Guanjian L. Elemene for the treatment of lung cancer. Cochrane Database of Systematic Reviews. 2007(4):1-13.

  8. Li QQ, Wang G, Reed E, Huang L, Cuff CF. Evaluation of Cisplatin in Combination with beta-Elemene as a Regimen for Prostate Cancer Chemotherapy. Basic Clin Pharmacol Toxicol. 2010 Nov;107(5):868-76.

  9. Li QQ, Wang G, Huang F, Banda M, Reed E. Antineoplastic effect of beta-elemene on prostate cancer cells and other types of solid tumour cells. J Pharm Pharmacol. 2010 Aug;62(8):1018-27.

  10. Wang B, Peng XX, Sun R, et al. Systematic review of β-elemene injection as adjunctive treatment for lung cancer. Chin J Integr Med. 2012 Nov;18(11):813-23.

  11. Li J, JunYu, Liu A, Wang Y. β-Elemene against human lung cancer via up-regulation of P53 protein expression to promote the release of exosome. Lung Cancer. 2014 Aug 29. pii: S0169-5002(14)00360-2.

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