Oldenlandia diffusa

Oldenlandia diffusa

Oldenlandia diffusa

Common Names

  • Bai Hua She She Cao
  • Herba Oldenlandiae
  • Snake-Needle Grass

For Patients & Caregivers

Oldenlandia diffusa showed anticancer effects in lab studies. Human data are lacking.

O. diffusa is an herb found in East Asia and Southern China. It is used in traditional Chinese medicine for the treatment of liver diseases, snake bites, and tumors. Laboratory studies suggest that this herb may inhibit the growth of cancer cells and kill them by causing programmed cell death and by stimulating the immune system to destroy or engulf tumor cells. Studies show that certain chemicals found in the herb help lower cholesterol in mice and have anti-inflammatory effects in mice with rheumatoid arthritis.

More research is necessary to confirm whether this herb can be used safely and effectively for any condition in humans.

  • Hepatitis
    There are no data to support this claim.
  • Cancer
    Several lab and animal studies have shown that Oldenlandia diffusa has anticancer effects. Human data are lacking.
  • Snake bite
    Although traditionally used to treat snake bite, there are no studies to back this claim.
  • Arthritis
    A study in mice showed that a component of O. diffusa had anti-inflammatory effects and it did not induce gastric problems compared with ibuprofen, a nonsteroidal anti-inflammatory drug.
  • High cholesterol
    Three compounds isolated from O. diffusa were shown to lower cholesterol levels in mice.

Poor quality control has been reported with products containing of O. diffusa. Two similar species – Corymbosa LAM and Oldenlandia tenelliflora BL – are commonly used as substitutes for Herba Oldenlandiae, the powdered form of O. diffusa.

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For Healthcare Professionals

Oldenlandia diffusa, Hedyotis diffusa

Oldenlandia diffusa, an herb prevalent in East Asia and Southern China, is used in traditional Chinese medicine to clear “heat” and to eliminate “toxins”. It is used in combination with other herbs for the treatment of hepatitis, snake bites (1), and tumors of the liver, lung, stomach (1), and rectum (2).

Studies conducted in vitro and in animals suggest that O. diffusa possesses anticancer and chemopreventive properties (2) (3) (4) (5) (6). Oleanolic and ursolic acids, compounds isolated from O. diffusa, demonstrated cytotoxic activity (7) (8) (11) (12). Ursolic acid also showed anti-inflammatory effects in mice with rheumatoid arthritis (9). Human data are lacking.

  • Hepatitis
  • Cancer treatment
  • Snake bite
  • Arthritis
  • High cholesterol

Studies conducted in vitro and in animals have shown that O. diffusa exerts antitumor effects via apoptosis (3), dose-dependent increase of oxidative burst (2), caspase-dependent apoptosis (4) (8), and apoptosis in a cell-cycle independent fashion possibly through the induction of genotoxic damage (6). Its immunomodulating effects are via stimulation of the immune system to kill or engulf tumor cells (5).

The anti-inflammatory activity of Oldenlandia is due to inhibition of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and prostaglandin E2 (PGE2) in mouse peritoneal macrophages (13).

Quality control issues have been reported. Two similar species – Corymbosa LAM and Oldenlandia tenelliflora BL – are commonly used as substitutes for Herba Oldenlandiae (the powdered form of O. diffusa(10).


  1. Wong BY, Lau BH, Jia TY, Wan CP. Oldenlandia diffusa and Scutellaria barbata augment macrophage oxidative burst and inhibit tumor growth. Cancer Biother Radiopharm. Feb 1996;11(1):51-56.

  2. Gupta S, Zhang D, Yi J, Shao J. Anticancer activities of Oldenlandia diffusa. J Herb Pharmacother. 2004;4(1):21-33.

  3. Shan BE, Zhang JY, Du XN. [Immunomodulatory activity and anti-tumor activity of Oldenlandia diffusa in vitro]. Zhongguo Zhong Xi Yi Jie He Za Zhi. May 2001;21(5):370-374.

  4. Willimott S, Barker J, Jones LA, Opara EI.Apoptotic effect of Oldenlandia diffusa on the leukaemic cell line HL60 and human lymphocytes. J Ethnopharmacol. Dec 3 2007;114(3):290-299.

  5. Wu PK, Chi Shing Tai W, Liang ZT, Zhao ZZ, Hsiao WL. Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. Life Sci. Jul 17 2009;85(3-4):113-121.

  6. Liang ZT, Jiang ZH, Leung KS, Peng Y, Zhao ZZ. Distinguishing the medicinal herb Oldenlandia diffusa from similar species of the same genus using fluorescence microscopy. Microsc Res Tech. Apr 2006;69(4):277-282.

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