For Patients & Caregivers
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How It Works
Animal studies suggest pao pereira has antimalarial and anticancer effects, but human studies have not been conducted.
Pao pereira is a tree native to the northern part of South America. Preparations made from the stem bark are used in folk medicine as sexual stimulants and to treat malaria, digestive disorders, constipation, fever, liver pain, and cancer. Preclinical studies suggest the bark extracts have antimalarial and pain-relieving properties, may help improve cognition, and may also have anticancer effects, but studies in humans are lacking.
Pao pereira is also marketed in supplemental form as an alternative anticancer treatment. However, its safety and effectiveness has not been determined in humans.
Lab experiments and animal studies suggest antimalarial activity.
Although used for this purpose in folk medicine, scientific evidence is lacking.
Pao pereira extracts appeared to relieve pain in animal models. Studies in humans are lacking.
Although used for this purpose in folk medicine, scientific research has not been conducted.
Although preclinical studies suggest anticancer activity, these extracts have not been studied in humans.
Do Not Take If
For Healthcare Professionals
Pao pereira is a tree native to the northern part of South America. It belongs to the family Apocyanaceae. Both aqueous and alcoholic decoctions prepared from the stem bark are used in folk medicine as sexual stimulants and to treat a variety of ailments including malaria, digestive disorders, constipation, fever, liver pain, and cancer.
Studies in vitro and in animal models using the bark extracts indicate antimalarial (1), antinociceptive (2) (11), and anti-inflammatory (11) effects, as well as anticholinesterase activity resulting in reversal of cognitive defects (3). This property is being explored as a potential treatment for Alzheimer’s disease (4). Flavopereirine derived from pao pereira demonstrated activity against leishmaniasis in vitro (13).
The anticancer potential of pao pereira has also been investigated. In preclinical studies, the bark extracts demonstrated antitumor activity and enhanced carboplatin effects in ovarian cancer cells (5). It also suppressed the growth of prostate cancer (6) (7) and pancreatic cancer cells along with potentiating gemcitabine effects (8), and inhibited pancreatic cancer stem-like cells (12). However, clinical trials have not yet been conducted.
Pao pereira is marketed in supplemental form as an alternative anticancer treatment, but safety and efficacy has not been determined.
Mechanism of Action
Bioactive compounds in pao pereira known as indole alkaloids showed antiplasmodial activity against a chloroquine-sensitive strain of Plasmodium falciparum, the causative agent of malaria. Of five alkaloids tested, geissolosimine demonstrated the highest activity (1). In a murine model, the crude extract and dichloromethane fraction exerted antinociceptive effects against acetic acid and formalin-induced-nociception via stimulation of the 5-HT 1A receptor, which is involved in neuromodulation (2). In another animal study, geissospermine, the most abundant alkaloid, inhibited acetylcholinesterase, resulting in increased levels of acetylcholine and reduced amnesia induced by scopolamine (3).
Anticancer effects are attributed to various mechanisms. Preclinical studies suggest pao pereira induces apoptosis via cleavage of caspases 3 and 8 and PARP, associated with DNA damage and cell cycle inhibition (8). Reduced tumor cell growth and apoptosis in prostate cancer cells may occur via beta-carboline alkaloids that upregulate DNA repair response genes as well as genes involved in the apoptotic pathway (6). Another study suggests the extract induces cell growth arrest and apoptosis partially via inhibition of NFκB activation (7).