- African plum tree
For Patients & Caregivers
How It Works
Pygeum may relieve symptoms of benign prostatic hypertrophy (BPH), but its effects following long-term use are not known.
Pygeum extracts have been used in traditional medicines for prostate gland inflammation, urinary problems, and other uses. Several compounds present in pygeum may reduce inflammation by stopping the production of prostaglandins, which are indicators of inflammation in the body. These compounds may also work together to reduce testosterone levels in the prostate. Although several small clinical trials suggest benefit, larger trials are needed to confirm safety and effectiveness.
- To treat benign prostatic hypertrophy (BPH) Several clinical trials show that pygeum is effective in improving urination symptoms in patients with BPH, but long-term effectiveness and safety are not known.
- To reduce inflammation Laboratory studies show that chemicals in pygeum have anti-inflammatory effects, but human data are lacking.
- To improve sexual performance No scientific evidence supports this use.
For Healthcare Professionals
Derived from the tree bark, pygeum extracts are traditionally used to manage lower urinary tract symptoms associated with benign prostatic hypertrophy (BPH) (1). In vitro and in vivo studies indicate that pygeum extracts have bactericidal and fungicidal activity (2), antagonize the androgen receptor (3), and have antiproliferative and apoptotic effects against prostate cancer cells (4) (5) (6) (7).
Clinical studies suggest effectiveness of pygeum (8) (9) (10) (11) and formulations containing pygeum and other herbs (12) to improve urinary symptoms associated with BPH. However, additional larger studies are needed to demonstrate usefulness of pygeum compared with standard treatments in current use for BPH.
Mechanism of Action
Pygeum antagonizes 5-lipoxygenase metabolite production, and this action may contribute to its anti-inflammatory effects (15). Antimicrobial effects have been linked to inhibition of IL-7 mRNA expression (2).
The isolated compounds atraric acid and N-butylbenzene-sulfonamide were identified as androgen receptor antagonists, which play an important role in the development of prostate diseases (16).
Antiproliferative and apoptotic effects of pygeum on prostate fibroblasts and myofibroblasts are due to downregulation of transforming growth factor B1 (TGFB1) and inhibition of fibroblast growth factor 2 (FGF2)-specific signaling (6).