Common Names
- Kaa he-he
- Sweet herb of Paraguay
- Caa-ehe
- Honey leaf
For Patients & Caregivers
How It Works
Stevia is used as a substitute for sugar.
Stevia is an herb that is used as a sweetener. The FDA allows only a purified ingredient from stevia as a food additive. Animal and laboratory studies suggest stevia products can suppress inflammation in the body or help regulate blood sugar, but studies of benefits in humans are unclear.
Purported Uses
Special Point
For Healthcare Professionals
Clinical Summary
Stevia rebaudiana is an herb native to Brazil and Paraguay. Its raw leaves as well as purified extracts such as stevioside and steviol have been used as sweeteners and promoted as sugar substitutes for diabetics (2). Stevia extract is many times sweeter than table sugar (1), but only purified steviol glycosides have the Generally Recognized as Safe (GRAS) status by the FDA for use in food (8).
In vitro and animal studies sugest that stevia has anti-inflammatory (5) (6), hepatoprotective and renoprotective effects (11). In humans, small studies suggest stevia may reduce hypertension and hyperglycemia (3) (4) (13), but a meta-analysis of steviol glycosides on type 2 diabetes biomarkers did not find significant benefit (14). In an RCT comparing low-calorie sweeteners, ingestion of rebaudioside did not appear to affect body weight (15). Additional studies are needed to clarify any benefits.
Mechanism of Action
The mechanisms underlying the antihypertensive effect of stevioside are still unclear, although it is believed to act as a calcium channel antagonist, similar to the drug verapamil (9). Other studies indicate steviosides are metabolized in the gut where bacteria provide an aglycone metabolite that then enters the blood circulation (16).
In vitro studies suggest stevioside suppresses production of inflammatory mediators (6). In mouse skin, it inhibited tumor-promoting 12-O-tetradecanoylphorbol-13-acetate (5). In other animal studies, stevia products inhibited hepatic gluconeogenesis (10) and increased insulin sensitivity (11).
Warnings
Laboratory studies indicate weak mutagenic activity with large doses (7).
Contraindications
Pregnant women should not consume this herb, as there is a lack of knowledge on how non-nutritive sweeteners including stevia may affect offspring (16).
Adverse Reactions
Case Reports
Four patients in a study experienced abdominal fullness, myalgia, nausea, and asthenia following consumption of 500 mg stevioside powder. Symptoms resolved after 1 week of treatment (4).