- Transfer Factor
For Patients & Caregivers
Transfer factors have not been shown to treat or prevent cancer.
Transfer factors are a group of proteins produced by cells of immune system. Some studies have shown that transfer factors can be used for treatment of herpes, infections in children, chronic fatigue syndrome, and yeast infections. They may also boost the immune system in patients with AIDS. More research is needed to determine the anticancer effects of transfer factors.
- To treat cancer
Although some studies have shown that transfer factors can have some positive effects in cancer patients, further research is needed to confirm such observations.
- To treat multiple sclerosis
This use is not supported by scientific evidence.
- To treat HIV/AIDS
One study showed that transfer factors increased the number of white blood cells in patients with AIDS.
- To treat herpes and Epstein-Barr virus
Studies have shown some signs of efficacy in treating herpes.
- To treat hepatitis (inflammation of liver)
Transfer factors were not effective in treating hepatitis.
- To treat asthma
Some studies have shown that transfer factor does not benefit patients with asthma.
- To treat chronic fatigue syndrome
Transfer factor was shown to have positive effects in the treatment of chronic fatigue syndrome.
For Healthcare Professionals
Transfer factors are a complex group of more than 200 highly polar, hydrophilic, low molecular weight (less than 12,000 Daltons) proteins produced in small quantities by lymphoid cells (1). Their precise molecular structure has not been determined. They carry with them the parent lymphocyte’s delayed-type hypersensitivity and cell-mediated immunity and pass it along to non-immune recipients, and appear to function across species. Transfer factors can be extracted from human or animal white blood cells, cloned lymphocytes grown in vitro, colostrum, and egg yolk. They appear to be well tolerated and in clinical settings have shown some signs of efficacy in treatment of herpes (2), acute infection in children (3), chronic fatigue syndrome (4), and Candidiasis (5). One study showed effectiveness in increasing white blood cells, CD8 lymphocytes and interleukin 2 levels among patients with HIV (6). Transfer factors are ineffective in treating hepatitis (7), multiple sclerosis (8), extrinsic bronchial asthma (9), human warts (10), juvenile rheumatoid arthritis (28), and acne vulgaris (11).
Studies have shown transfer factors ineffective in treating malignant melanoma (12), nasopharyngeal carcinoma (13), bronchogenic carcinoma (14), Hodgkin’s disease (15), osteogenic sarcoma (16), and mycosis fungoides (17). In rats, transfer factors were shown to reduce tumor size and increase peripheral blood T-lymphocyte counts (21). Transfer factors show signs of effectiveness in increasing survival rates among patients with Stage I adenocarcinoma of the lung (18) and Stage I cervical cancer (19), but further research is warranted. In a study of children with leukemia, immunization with transfer factors conferred protection against varicella-zoster infection (20).
Overall, there is a paucity of large randomized controlled clinical trials, and a need for further research into the effectiveness of transfer factors.
Though the exact mechanisms of transfer factors remain unknown, they contain many molecules, some of which act in an antigen-specific manner, while others have been shown to have immunomodulating capabilities (1). Human leukocyte dialysates (DLE) contain low molecular peptides that were characterized in the late 1980s as amino terminal ends of enkephalins. A low molecular weight sub fraction derived from DLE, IMREG-1, has been shown to enhance cell mediated immunity (22). In vitro studies have shown that both cells murine recipients and humans treated for herpes zoster virus infection secrete gamma-interferon in response to transfer factors (23). Studies have also suggested that production of transfer factors, but not the immunologic activities, is regulated by immune response (Ir) genes. (24).