Yu Ping Feng San

Purported Benefits, Side Effects & More

Yu Ping Feng San

Purported Benefits, Side Effects & More
Yu Ping Feng San

Common Names

  • Jade Windscreen Powder
  • Yu Ping Feng decoction
  • Yu Ping Feng Wan
  • Yu Ping Feng Pian

For Patients & Caregivers

Tell your healthcare providers about any dietary supplements you’re taking, such as herbs, vitamins, minerals, and natural or home remedies. This will help them manage your care and keep you safe.


What is it?

Yu Ping Feng San (YPFS) is a traditional Chinese medicine (TCM) formula. It’s made up of three different herbs.

What are the potential uses and benefits?

Yu Ping Feng San is used to treat:

  • Cold
  • Influenza
  • Asthma
  • Allergic rhinitis (allergic reaction that causes congestion, sneezing, and sore throat)
  • Chronic obstructive pulmonary disease (COPD) (lung diseases that restrict your breathing)

Talk with your healthcare providers before taking herbal formulas. They can interact with some medications and affect how they work. For more information, read the “What else do I need to know?” section below.

What are the side effects?

YPFS can cause mild side effects that include:

  • Sleepiness
  • Headache
  • Stomach discomfort
  • Fatigue
  • Skin rash
  • Dry mouth
What else do I need to know?
  • Talk to your healthcare provider if you take medications that suppress your immune system. YPFS may make them less effective.
  • Talk to your healthcare provider if you are pregnant or breastfeeding. YPFS may not be safe for you. 

For Healthcare Professionals

Clinical Summary

Yu Ping Feng San (YPFS) is a traditional Chinese medicine (TCM) formula first documented in the ancient text Dan Xi Xin Fa. A blend of three herbs – Huang Qi (Astragalus mongholicus Bunge), Bai Zhu (Adactylies macrocephala Koidz Rhizome), and Fang Feng (Saposhnikovia divaricata Schischk) – YPFS is used to treat respiratory disorders including cold, influenza, nasal congestion, and asthma.

Limited clinical data suggest benefits of YPFS for allergic rhinitis (1) (2) and COPD (3). It was also effective in pediatric patients with asthma (4) although more data are needed to determine utility in those with allergic rhinitis (5).

In preclinical studies, YPFS demonstrated anticancer properties (6) (7) and enhanced the anticancer effects of cisplatin in non-small cell lung cancer cells (8) (9). A small study of end-stage cancer patients found YPFS beneficial in reducing idiopathic sweating (10).

More research is needed to bolster the evidence surrounding this formula.

Purported Uses and Benefits
  • Cold
  • Influenza
  • Asthma
  • Allergic rhinitis
  • COPD
Mechanism of Action

One of the proposed mechanisms through which YPFS exerts anti-influenza effects is by suppressing neuraminidase activity of the virus, preventing its release and spread (11). Its effectiveness against allergic rhinitis is thought to be via regulating several signaling pathways including tumor necrosis factor and interleukin-17 (12).

In murine models, YPFS reversed drug resistance of cisplatin in lung cancer cells by down regulating the activities and expression of ATP-binding cassette transporters and glutathione S-transferases (GSTs) (8). It was also found to alleviate lung injury in COPD models by suppressing release of pro-inflammatory cytokines and collagen deposition (13).

Contraindications
  • Because YPFS contains Huang Qi (Astragalus mongholicus Bunge), an immunostimulant, it should be avoided in patients taking immuosuppressives (14).
  • Pregnant/breastfeeding women should avoid this formula.
Adverse Reactions
  • Sleepiness, headache, GI discomfort, fatigue, rash, and dry mouth in pediatric patients (4)
  • Nausea, diarrhea and allergy in end-stage cancer patients (10)

The above effects were mild and abated when treatment was stopped.

Dosage (OneMSK Only)
References
  1. Luo Q, Zhang CS, Yang L, Zhang AL, Guo X, Xue CC, Lu C. Potential effectiveness of Chinese herbal medicine Yu ping feng san for adult allergic rhinitis: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Altern Med. 2017 Nov 6;17(1):485.
  2. Luo Q, Zhang CS, Yang L, Zhang AL, Guo X, Xue CC, Lu C. Potential effectiveness of Chinese herbal medicine Yu ping feng san for adult allergic rhinitis: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Altern Med. 2017 Nov 6;17(1):485.
  3. Min J, Mao B, Jiang HL, Fan T, Zhou W. [Effects of “reinforcing Qi and activating blood” on stable chronic obstructive pulmonary disease (Qi deficiency and blood stasis syndrome].  Sichuan Da Xue Xue Bao Yi Xue Ban. 2014 Jul;45(4):601-5.
  4. Chan PH, To CY, Chan EY-T, et al. A randomized placebo-controlled trial of traditional Chinese medicine as an add-on therapy to oral montelukast in the treatment of mild persistent asthma in children. Complement Ther Med. 2016 Dec;29:219-228.
  5. Liao Y, Zhong J, Liu S, et al. Yu ping feng san for pediatric allergic rhinitis: A systematic review and meta-analysis of randomized controlled trials. Medicine (Baltimore). 2021 Apr 2;100(13):e24534.
  6. Yao F, Yuan Q, Yan Y, et al. Yu-Ping-Feng-San improve the immunosuppression of microenvironment in hepatocellular carcinoma by promoting the maturation of DCs through the JAK2-STAT3 pathway. Sci Rep. 2024 Dec 28;14(1):31522.
  7. Yuan Q, Yao F, Zhou L, et al. Yu Ping Feng San Exert Anti-Angiogenesis Effects through the Inhibition of TSLP-STAT3 Signaling Pathways in Hepatocellular Carcinoma. Evid Based Complement Alternat Med. 2019 Oct 23;2019:1947156.
  8. Du Y, Zheng Y, Yu CX, et al. The Mechanisms of Yu Ping Feng San in Tracking the Cisplatin-Resistance by Regulating ATP-Binding Cassette Transporter and Glutathione S-Transferase in Lung Cancer Cells. Front Pharmacol. 2021 May 28;12:678126.
  9. Lou JS, Yan L, Bi CW, et al. Yu Ping Feng San reverses cisplatin-induced multi-drug resistance in lung cancer cells via regulating drug transporters and p62/TRAF6 signalling. Sci Rep. 2016 Aug 25;6:31926.
  10. Chiu SC, Lai YL, Chang HH, et al. The therapeutic effect of modified Yu Ping Feng San on idiopathic sweating in end-stage cancer patients during hospice care. Phytother Res. 2009 Mar;23(3):363-6.
  11. Du CY, Zheng KY, Bi CW, et al. Yu Ping Feng San, an Ancient Chinese Herbal Decoction, Induces Gene Expression of Anti-viral Proteins and Inhibits Neuraminidase Activity. Phytother Res. 2015 May;29(5):656-61.
  12. Yang S, Fu Q, Deng H, et al. Mechanisms and molecular targets of the Yu-Ping-Feng powder for allergic rhinitis, based on network pharmacology. Medicine (Baltimore). 2021 Sep 3;100(35):e26929.
  13. Yang ZS, Yan JY, Han NP, et al. Anti-inflammatory effect of Yu-Ping-Feng-San via TGF-β1 signaling suppression in rat model of COPD.  Iran J Basic Med Sci. 2016 Sep;19(9):993-1002.
  14. Liu P, Zhao H, Luo Y. Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic. Aging Dis. 2017 Dec 1;8(6):868-886.
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