For Patients & Caregivers
Tell your healthcare providers about any dietary supplements you’re taking, such as herbs, vitamins, minerals, and natural or home remedies. This will help them manage your care and keep you safe.
How It Works
Zestra may improve sexual function in normal women and in those suffering from female sexual disorders.
Zestra is a personal product for women that contains borage seed oil, evening primrose oil, angelica root extract, Coleus forskohlii extract, ascorbyl palmitate, and dl-alpha tocopherol.. It is being promoted to relieve symptoms of female sexual dysfunction. Sexual dysfunction may include painful intercourse, loss of desire, and difficulty in achieving arousal or orgasm. Stress, changes in hormone, cancer treatment, drugs, or menopause are some of the factors that can cause sexual dysfunction. Scientists believe that the borage, evening primrose, angelica, and Coleus forskohlii may be responsible for Zestra’s activity. A small study showed that Zestra can improve sexual function in both normal women and in those suffering from female sexual arousal disorder.
Zestra has not been studied in cancer patients. Women who are pregnant, breastfeeding, or those trying to get pregnant should not use Zestra.
Do Not Take If
For Healthcare Professionals
Zestra is a topical botanical formulation of borage seed oil, evening primrose oil, angelica root extract, Coleus forskohlii extract, ascorbyl palmitate, and dl-alpha tocopherol. It is promoted to relieve symptoms associated with female sexual dysfunction. Sexual dysfunction may involve painful intercourse, loss of libido, difficulty in maintaining arousal, or difficulty in achieving orgasm. Causative factors include stress, hormonal changes, cancer treatment involving surgery, radiation, chemotherapy or hormone therapy, use of antidepressants, or menopause. The borage, primrose, angelica, and coleus extracts may contribute to Zestra’s activity by increasing blood flow and nerve conduction (2) (3) (4). Clinical studies show that it benefits both normal women and those with sexual disorders by heightening desire, arousal, and increased sexual pleasure (1) (6).
Zestra has not been studied in cancer patients. Adverse effects from its use include mild burning sensation locally. It is contraindicated in women who are pregnant, breastfeeding, and in those trying to conceive.
Mechanism of Action
Studies show that borage and evening primrose oils are rich in gamma-linolenic acid that is metabolized to prostaglandin E1 in the skin (2). This process is known to increase blood flow and nerve conduction. Osthole, a compound present in Angelica root extract was found to increase the levels of cGMP and cAMP (3). The Coleus forskohlii extract contains forskolin, coleonol, and related diterpenes that are known to stimulate adenylate cyclase (4).