Primary Brain Tumor Clinical Trials & Research

VIDEO |

What is a Clinical Trial?

This video explains what clinical trials are and may help you decide if taking part in one is the right choice for you.
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Clinical trials at Memorial Sloan Kettering Cancer Center may give you access to new therapies that aren’t widely available. These research studies evaluate the safety and effectiveness of new ways to diagnose and treat primary brain tumors. They can also give your treatment team information about your current plan of care.

Because doctors from different disciplines work together closely through our collaborative Brain Tumor Center, many of our clinical trials combine different treatment approaches, such as radiation therapy and chemotherapy. These aggressive approaches show promise for improving the treatment of many types of brain tumors.

Our experts can help determine which clinical trial is right for you, including some of our newly opened clinical trials:

As a member of the North American Brain Tumor Coalition, we offer qualified patients access to several clinical trials sponsored by the National Cancer Institute.

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26 Clinical Trials found
A Phase 1b Study of Epcoritamab and Ibrutinib Given Together in People With Central Nervous System Lymphoma
Researchers want to see if the combination of epcoritamab and ibrutinib is a safe treatment for people with central nervous system lymphoma (CNSL) that keeps growing or came back after treatment.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 1b/2 Study of Pembrolizumab, Ibrutinib, and Rituximab in People With Primary Central Nervous System Lymphoma
Researchers want to see if combining pembrolizumab, ibrutinib, and rituximab works well against primary central nervous system lymphoma (PCNSL). The people in this study have PCNSL that keeps growing or came back even with treatment.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 2 Study of a Lower Radiation Therapy Dose to Treat Children and Young Adults With Central Nervous System Germinoma
Researchers are assessing a lower dose of standard radiation therapy after chemotherapy in young people with germinomas. The patients in this study have germinomas of the central nervous system (brain or spinal cord).  It is hoped that this new approach can destroy germinomas with fewer long-term side effects.
New York City
A Phase 2 Study of Cabozantinib in People With Meningioma
Researchers want to see how well cabozantinib works to treat meningioma, a type of brain tumor. The people in this study have meningiomas that came back or keep growing even after treatment.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 2 Study of FORE8394 in People Who Have Cancer With BRAF Mutations
Researchers are seeing how well the drug FORE8394 works in people with advanced solid tumors, including brain tumors. The people in this study include adults and children with cancers that keep growing or came back even with treatment. Their tumors have mutations (changes or variants) in the BRAF gene.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 2 Study of Lisocabtagene Maraleucel CAR T-Cell Therapy in People With Primary Central Nervous System Lymphoma
Researchers are assessing the cellular therapy lisocabtagene maraleucel (liso-cel) in people with primary central nervous system lymphoma (PCNSL). The people in this study have PCNSL that has not yet been treated. In addition, they cannot have autologous stem cell transplantation (ASCT). During ASCT, a patient's healthy, blood-forming cells are collected before treatment, stored, and returned after treatment with very strong chemotherapy.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 2 Study of Safusidenib in People With Glioma
Researchers are seeking the best dose of safusidenib erbumine to treat glioma that came back or keeps growing after treatment. The people in this study have glioma with a mutation (change or variant) in a gene called IDH1. Many gliomas have IDH1 mutations, which help cancer cells survive and grow.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 3 Study Comparing 1 Radiation Therapy Treatment Versus 3 Radiation Treatments Over a Week for Brain Metastases
The usual treatment for brain metastases (cancer that spread to the brain) is a single treatment of stereotactic radiosurgery (SRS). SRS uses special equipment to position the patient and precisely give a single large dose of radiation to a tumor.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase 3, Multi-regional, Open-label, Randomized Study of Tirabrutinib vs Rituximab and Temozolomide in Participants With Relapsed/Refractory Primary Central Nervous System Lymphoma
To learn more about the purpose of this study and to find out who can join, please click here to visit ClinicalTrials.gov for a full clinical trial description.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau
A Phase I/II Study of Selinexor and Radiation Therapy for Newly Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma and High-Grade Glioma
The purpose of this study is to find the best dose of the drug selinexor that can be given safely with radiation therapy in young patients newly diagnosed with pediatric diffuse intrinsic pontine glioma (DIPG) or high-grade glioma. Researchers will also determine the effectiveness of combining selinexor with radiation therapy (given for eight weeks) followed by selinexor therapy alone for two years.
New York City, Commack, Basking Ridge, Westchester, Monmouth, Bergen, Nassau