Multiple Myeloma Clinical Trials & Research

MSK is a major research institution. During your treatment for multiple myeloma, your care team may ask if you want to join a clinical trial.

What is a clinical trial?

Clinical trials are research studies that test new treatments, procedures, or devices to see how well they work. They are an important part of helping to prevent, treat, and cure cancer. Almost every cancer treatment given to patients was first tested during a clinical trial.

MSK tests new treatments for multiple myeloma. In general, treatment trials test new drugs, drug combinations, devices, and ways of doing procedures, surgery, or radiation therapy.

Sometimes a clinical trial gives you access to new therapies that are not yet available at most hospitals. Talk with your doctor about whether joining a clinical trial is right for you.

Clinical trials are designed to answer questions about:

  • Safety
  • Benefits
  • Side effects
  • Whether some people are helped more than others

MSK will start a clinical trial only if our researchers think we can improve methods for cancer:

  • Prevention
  • Treatment
  • Diagnosis
  • Screening

For more information, please read Clinical Trials at MSK: What You Need to Know.

Clinical trials to improve treatments for multiple myeloma

MSK is researching new ways to evaluate people with myeloma just when they’re diagnosed. We aim to evaluate how they may respond to treatment.

MSK researchers are learning more about the genetics of multiple myeloma. We are using this knowledge to find better drugs to control the disease.

We look for changes (mutations and variants) that can make the cancer worse. MSK has a team of experts in using diagnostic tools, such as DNA sequencing or microarray analysis. A microarray is a lab tool that can analyze thousands of genes at one time. 

Through MSK clinical trials, we’re exploring the best ways to combine standard chemotherapy drugs with immune-modifying drugs. We also are testing newer immunotherapies and mechanisms of action (how a drug affects the body).

You can search below for the latest list of MSK’s clinical trials for multiple myeloma and related plasma cell diseases.

and/or
37 Clinical Trials found
Autologous stem cell transplant (ASCT) is a standard treatment for multiple myeloma. An ASCT replaces the blood-forming cells destroyed by disease or treatment with healthy cells collected from your blood. Before ASCT, people generally receive a standard drug, melphalan, to prepare the body for the transplant.
Teclistamab is given as an injection under the skin. The goal is to see if lower doses or stopping treatment will have the same benefit with fewer side effects.
Researchers are comparing three different treatments for multiple myeloma. The people in this study have multiple myeloma that came back or keeps growing even after treatment. If you join this study, you will be randomly assigned to get one of these treatments:
Researchers are comparing two new combination drug treatments with the standard therapy for multiple myeloma. The people in this study have multiple myeloma that is newly diagnosed. In addition, they cannot have an autologous stem cell transplant with high-dose chemotherapy.
Researchers want to know if eating a plant-based diet and taking certain nutritional supplements may be helpful for reducing the risk of progression to multiple myeloma in people with monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM). People with MGUS and SMM have an abnormal protein called the M protein in their blood and are at risk of developing multiple myeloma.
To learn more about the purpose of this study and to find out who can join, please click here to visit ClinicalTrials.gov for a full clinical trial description.
To learn more about the purpose of this study and to find out who can join, please click here to visit ClinicalTrials.gov for a full clinical trial description.
To learn more about the purpose of this study and to find out who can join, please click here to visit ClinicalTrials.gov for a full clinical trial description.
To learn more about the purpose of this study and to find out who can join, please click here to visit ClinicalTrials.gov for a full clinical trial description.