Andrew McPherson is an Assistant Laboratory Member at the Memorial Sloan Kettering Cancer Center in the Department of Epidemiology and Biostatistics under the supervision of Dr. Sohrab Shah. Andrew completed a PhD in computing science at Simon Fraser University under the supervision of Dr. Cenk Sahinalp and Dr. Sohrab Shah, focusing on methods for sequencing analysis, including detection and characterization of genome rearrangements, and inference of clonal phylogenies. During his post-doctoral research at University of British Columbia with Dr. Sohrab Shah, Andrew focused on the development of computational methods and infrastructure for a novel single cell sequencing plaform, Direct Library Preparation. Andrew moved to MSKCC in May of 2019 and plans to build on his post-doctoral work in single cell genomics to understand genomic instability, mutational processes, clonal evolution and the role of the microenvironment in cancer development and progression.
Andrew has expertise in combinatorial optimization, machine learning and probabilistic modeling. He is interested in studying cancer biology problems that are combinatorially difficult to model, including phylogenetic inference, genome rearrangements, and clonal mixture decomposition. He focuses on problems relevant to cancer genomics; specifically chromosomal instability and its reshaping of chromosomes, mutational processes and the signatures they imprint on the genome, and interaction between tumour cells and the tumour microenvironment. In addition, he has an interest in big data software engineering and the development of optimal scientific discovery informatic workflows and processes.
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Andrew McPherson discloses the following relationships and financial interests:
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