Andrew McPherson

Assistant Attending

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Andrew McPherson

Andrew McPherson is an Assistant Laboratory Member at the Memorial Sloan Kettering Cancer Center in the Department of Epidemiology and Biostatistics under the supervision of Dr. Sohrab Shah. Andrew completed a PhD in computing science at Simon Fraser University under the supervision of Dr. Cenk Sahinalp and Dr. Sohrab Shah, focusing on methods for sequencing analysis, including detection and characterization of genome rearrangements, and inference of clonal phylogenies. During his post-doctoral research at University of British Columbia with Dr. Sohrab Shah, Andrew focused on the development of computational methods and infrastructure for a novel single cell sequencing plaform, Direct Library Preparation. Andrew moved to MSKCC in May of 2019 and plans to build on his post-doctoral work in single cell genomics to understand genomic instability, mutational processes, clonal evolution and the role of the microenvironment in cancer development and progression.

Andrew has expertise in combinatorial optimization, machine learning and probabilistic modeling. He is interested in studying cancer biology problems that are combinatorially difficult to model, including phylogenetic inference, genome rearrangements, and clonal mixture decomposition. He focuses on problems relevant to cancer genomics; specifically chromosomal instability and its reshaping of chromosomes, mutational processes and the signatures they imprint on the genome, and interaction between tumour cells and the tumour microenvironment. In addition, he has an interest in big data software engineering and the development of optimal scientific discovery informatic workflows and processes.

Publications

  1. Zhang AW, McPherson A, et al. Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer. Cell. 2018 Jun 14;173(7):1755-1769.e22. doi: 10.1016/j.cell.2018.03.073. Epub 2018 May 10. PubMed PMID: 29754820.

  2. McPherson AW, et al. ReMixT: clone-specific genomic structure estimation in cancer. Genome Biol. 2017 Jul 27;18(1):140. doi: 10.1186/s13059-017-1267-2. Erratum in: Genome Biol. 2017 Oct 6;18(1):188. PubMed PMID: 28750660; PubMed Central PMCID: PMC5530528.

  3. McPherson A, et al. Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer. Nat Genet. 2016 Jul;48(7):758-67. doi: 10.1038/ng.3573. Epub 2016 May 16. PubMed PMID: 27182968.

To view more publications, visit PubMed