Andriy Derkach, PhD

Assistant Attending Biostatistician

Andriy Derkach, PhD

Assistant Attending Biostatistician


University of Toronto, Canada

Current Research Interest 

Dr. Derkach’s methodological research focuses on developing new statistical methods that integrate high dimensional molecular and genetic data to detect associations with disease. He is particularly interested in statistical methodologies for high dimensional mediation analysis. Mediation analysis has become a commonly used tool in epidemiologic studies. Dr. Derkach proposes novel methods that can handle some of the practical complexities of the large, complex datasets used by modern scientists.  His methodological updates to mediation analysis can better handle “big data” and show that the resulting inference can be used to improve risk prediction and discrimination of clinical outcomes. He also collaborates with clinical researchers in the Leukemia Service and the Myeloma Service at Memorial Sloan Kettering to design and analyze prospective and retrospective studies.


Selected peer-reviewed publications:

  1. Derkach A, Moore SC, Boca SM, Sampson JN. Group testing in mediation analysis. Stat Med. 2020 Aug 15;39(18):2423-2436. doi: 10.1002/sim.8546. Epub 2020 May 4. PMID: 32363646; PMCID: PMC8262108.
  2. Derkach A, Pfeiffer RM, Chen TH, Sampson JN. High dimensional mediation analysis with latent variables. Biometrics. 2019 Sep;75(3):745-756. doi: 10.1111/biom.13053. Epub 2019 May 5. PMID: 30859548.
  3. Derkach A, Lawless JF, Sun L. Score tests for association under response-dependent sampling designs for expensive covariates. Biometrika, 2015 102(4), 988–994.
  4. Derkach A, Kantor E, Sampson JN, Pfeiffer RM.  Mediation analysis using incomplete information from publicly available data sources,2023+, revision submitted, link to pdf.
  5. Derkach A, Sampson JN, Pfeiffer RM. Integrating incomplete data for mediation analysis. Statistica Sinica, 2022, Epub ahead of print, link to pdf.


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Andriy Derkach discloses the following relationships and financial interests:

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