Ed Reznik, PhD

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Ed Reznik, Assistant Attending

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Dr. Reznik is a computational biologist who is also affiliated with the Marie-Josée and Henry R. Kravis Center for Molecular Oncology and the Urology Service. His research applies computational and informatic approaches to address basic and translational questions in mitochondrial genetics, cancer metabolism, and cancer genomics. His lab studies how metabolic phenomena support the initiation, progression, and therapeutic susceptibility of tumors. He is also an active member of the Kidney Cancer Working Group and contributes to the analysis of genomic, metabolomic, and immunological data related to kidney cancer biology and therapy.


Selected peer-reviewed publications:

  1. Xu J, Reznik E, et al. Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma. Elife. 2019 Apr 1;8. pii: e38986. doi: 10.7554/eLife.38986. PubMed PMID: 30924768; PubMed Central PMCID: PMC6459676.
  2. Reznik E, et al. A Landscape of Metabolic Variation across Tumor Types. Cell Syst. 2018 Mar 28;6(3):301-313.e3. doi: 10.1016/j.cels.2017.12.014. Epub 2018 Jan 27. PubMed PMID: 29396322; PubMed Central PMCID: PMC5876114.
  3. Reznik E, et al. Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity. Cell Rep. 2017 Sep 12;20(11):2666-2677. doi: 10.1016/j.celrep.2017.08.066. PubMed PMID: 28903046; PubMed Central PMCID: PMC5600504.    
  4. Reznik E, et al. Mitochondrial respiratory gene expression is suppressed in many cancers. Elife. 2017 Jan 18;6. pii: e21592. doi: 10.7554/eLife.21592. PubMed PMID: 28099114; PubMed Central PMCID: PMC5243113.
  5. Reznik E, et al. Mitochondrial DNA copy number variation across human cancers. Elife. 2016 Feb 22;5. pii: e10769. doi: 10.7554/eLife.10769. PubMed PMID: 26901439; PubMed Central PMCID: PMC4775221.
  6. Hakimi AA, Reznik E, et al. An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma. Cancer Cell. 2016 Jan 11;29(1):104-116. doi: 10.1016/j.ccell.2015.12.004. PubMed PMID: 26766592; PubMed Central PMCID: PMC4809063.
  7. Reznik E, et al. Flux imbalance analysis and the sensitivity of cellular growth to changes in metabolite pools. PLoS Comput Biol. 2013;9(8):e1003195. doi: 10.1371/journal.pcbi.1003195. Epub 2013 Aug 29. PubMed PMID: 24009492; PubMed Central PMCID: PMC3757068.
  8. Reznik E, et al. The average enzyme principle. FEBS Lett. 2013 Sep 2;587(17):2891-4. doi: 10.1016/j.febslet.2013.07.032. Epub 2013 Jul 23. PubMed PMID: 23892076; PubMed Central PMCID: PMC3983706.
  9. Reznik E, et al. The dynamics of hybrid metabolic-genetic oscillators. Chaos. 2013 Mar;23(1):013132. doi: 10.1063/1.4793573. PubMed PMID: 23556969.
  10. Collins SB, Reznik E, et al. Temporal expression-based analysis of metabolism. PLoS Comput Biol. 2012;8(11):e1002781. doi: 10.1371/journal.pcbi.1002781. Epub 2012 Nov 29. PubMed PMID: 23209390; PubMed Central PMCID: PMC3510039.

View a complete listing of Ed Reznik’s publications