Nikolaus Schultz, PhD


Nikolaus Schultz, PhD

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Nikolaus Schultz was originally trained as a biochemist with a focus on molecular biology, then transitioned into bioinformatics and computational biology. He has extensive experience in the analysis of complex genomic data, especially in the context of signaling pathways. He currently leads the Knowledge Systems group in the Kravis Center for Molecular Oncology, where he oversees the implementation of the cBioPortal for Cancer Genomics and OncoKB, a knowledge base for Precision Oncology. Nikolaus was a co-founder of the cBioPortal software and has been involved in guiding its development since its inception, especially the design of features that are useful for researchers and clinicians – all influenced by his own strong interest in cancer genomics research. He also runs a research laboratory that explores the genomic alterations that underlie human cancer.


  1. Cerami E, …, Schultz N. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012 May;2(5):401-4. doi:10.1158/2159-8290.CD-12-0095. Erratum in: Cancer Discov. 2012 Oct;2(10):960.PubMed PMID: 22588877; PubMed Central PMCID: PMC3956037.
  2. Cancer Genome Atlas Research Network. The Molecular Taxonomy of Primary Prostate Cancer. Cell. 2015 Nov 5;163(4):1011-25. doi: 10.1016/j.cell.2015.10.025. PubMed PMID: 26544944; PubMed Central PMCID:PMC4695400.
  3. Ciriello G, …, Schultz N, Sander C. Emerging landscape of oncogenic signatures across human cancers. Nat Genet. 2013 Oct;45(10):1127-33. doi: 10.1038/ng.2762. PubMed PMID: 24071851; PubMed Central PMCID: PMC4320046.
  4. Domcke S, …, Schultz N. Evaluating cell lines as tumour models by comparison of genomic profiles. Nat Commun. 2013;4:2126. doi: 10.1038/ncomms3126. PubMed PMID: 23839242; PubMed Central PMCID: PMC3715866.
  5. Ciriello G, …, Schultz N. Mutual exclusivity analysis identifies oncogenic network modules. Genome Res. 2012 Feb;22(2):398-406. doi: 10.1101/gr.125567.111. Epub 2011 Sep 9. PubMed PMID: 21908773; PubMed Central PMCID: PMC3266046.
  6. Chakravarty D, …, Schultz N. OncoKB: A Precision Oncology Knowledge Base. JCO Precis Oncol. 2017 Jul;2017. doi: 10.1200/PO.17.00011. Epub 2017 May 16. PubMed PMID: 28890946; PubMed Central PMCID: PMC5586540.
  7. Sanchez-Vega F, …, Schultz N. Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell. 2018 Apr 5;173(2):321-337.e10. doi: 10.1016/j.cell.2018.03.035. PubMed PMID: 29625050; PubMed Central PMCID: PMC6070353.
  8. Armenia J, …; PCF/SU2C International Prostate Cancer Dream Team, Schultz N, Van Allen EM. The long tail of oncogenic drivers in prostate cancer. Nat Genet. 2018 May;50(5):645-651. doi: 10.1038/s41588-018-0078-z. Epub 2018 Apr 2. Erratum in: Nat Genet. 2019 Jul;51(7):1194. PubMed PMID: 29610475; PubMed Central PMCID: PMC6107367.
  9. Yaeger R, …, Schultz N. Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer. Cancer Cell. 2018 Jan 8;33(1):125-136.e3. doi: 10.1016/j.ccell.2017.12.004. PubMed PMID: 29316426; PubMed Central PMCID: PMC5765991.
  10. Janjigian YY, …, Schultz N. Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer. Cancer Discov. 2018 Jan;8(1):49-58. doi: 10.1158/2159-8290.CD-17-0787. Epub 2017 Nov 9. PubMed PMID: 29122777; PubMed Central PMCID: PMC5813492.

View a complete listing of Nikolaus Schultz’ publications