Memorial Sloan Kettering medical oncologist Eileen O'Reilly

Eileen M. O'Reilly, MD

Gastrointestinal Medical Oncologist

Areas of Expertise

Conditions I Treat

  • Pancreatic cancer
  • Gallbladder cancer
  • Bile duct cancer (cholangiocarcinoma)

My Specialties

  • Immunotherapy
  • Clinical trials
View all expertise
Dr. O'Reilly's Office Information
Languages: English
Request an Appointment
Our Care Advisors can answer many of your questions. They will connect you with the best healthcare provider for your needs.
Back to top
Share

Get to Know Me

I am a medical oncologist who cares for people with pancreatic and hepatobiliary (hep-uh-toh-BIL-ee-air-ee) cancers, including:

At Memorial Sloan Kettering Cancer Center (MSK), I work closely with a team of experts across medical areas. These include:

Together, we create a care plan that best treats each person’s cancer while honoring their personal wants and needs for cancer treatment. To achieve these goals, I communicate clearly and effectively with every patient, their family, and other team members. I strive for excellence in these areas as part of my commitment to offer the best possible care.

Read more

My research focuses on developing new therapies for pancreatic cancer, such as:

  • Gene-based treatments.
  • Immunotherapy (including vaccines).
  • Personalized treatments that target a cancer’s unique molecular makeup.

I also lead many clinical trials for people with this disease. Our hope is that this work leads to approved treatments that help people with pancreatic cancer live longer and have a better quality of life.

I co-direct a major federally-funded grant called the Specialized Program in Research Excellence (SPORE) for pancreatic cancer. This grant supports investigators using the latest molecular biology and clinical advances to improve care for people with pancreatic ductal adenocarcinoma (PDAC).

I have authored and co-authored more than 400 articles, editorials, and book chapters. I also serve as Associate/Senior Editor for several major journals.

In addition to caring for patients and leading research, I am Chair of MSK’s Human Research Protection Program and the Institutional Review and Privacy Board. In this role, I work closely with a team of people to oversee how research is conducted at MSK.

Education is another important part of my work. I teach and mentor national and international oncology fellows, junior faculty, residents, house staff, and students. It’s an honor to have been recognized with many teaching awards for these efforts.

Outside of MSK, I work with groups and experts around the world to improve care for people with pancreas and hepatobiliary cancers. I am Co-Chair of the National Cancer Institute (NCI) Alliance Co-Operative Group Gastrointestinal Cancers Committee and a member of the NCI’s Gastrointestinal Cancers Steering Committee. These committees are involved in developing and overseeing federally-funded clinical trials in gastrointestinal cancers.

I also serve on the medical and/or scientific advisory board of various organizations and other national/international committees including:

  • Pancreatic Cancer Action Network
  • American Society of Clinical Oncology Guidelines Committee
  • European Society of Medical Oncology Guidelines Committee
  • National Pancreas Foundation
  • Hirshberg Foundation
  • Avner Foundation

In my spare time, I enjoy being with my family, reading, classical music, traveling to Europe and Asia, cultivating plants, and watching films.

What I Do at MSK

I'm a gastrointestinal (GAS-troh-in-TES-tih-nul) medical oncologist, which is a cancer doctor who specializes in gastrointestinal (GI) cancers. This includes anal, colorectal, esophageal, gastric (stomach), liver, and pancreatic cancers. We also treat GI stromal tumors and neuroendocrine tumors.

  • Winthrop Rockefeller Endowed Chair of Medical Oncology
  • Chair, Human Research Protection Program and Institutional Review Board
  • Co-Director, Medical Initiatives, David M. Rubenstein Center for Pancreatic Cancer Research
  • Section Head, Hepatopancreaticobi
Areas of Expertise

Conditions I Treat

  • Pancreatic cancer
  • Gallbladder cancer
  • Bile duct cancer (cholangiocarcinoma)
  • Primary liver cancer

My Specialties

  • Immunotherapy
  • Clinical trials
Education & Honors

Education

  • MD, Trinity College, Ireland

Residencies

  • Internal Medicine - St. James's Hospital

Fellowships

  • Internal Medicine/Medical Oncology - St. Vincent's Hospital (Ireland)
  • Medical Oncology - Memorial Sloan Kettering Cancer Center
  • Medicine - Cornell University Medical Center

Board Certifications

  • Internal Medicine (Ireland)

Awards and Honors

  • Castle Connolly: America’s Top Doctor (2025)
  • Castle Connolly: Exceptional Women in Medicine (2024)
  • Castle Connolly: America’s Top Doctor (2024)
  • Top Doctors New York Metro Area, Castle Connolly (2023)
  • Giant of Cancer Care, Gastrointestinal Cancer, OncLive (2023)
  • Exceptional Women in Medicine Award, Castle Connolly (2023)
  • Castle Connolly: America's Top Doctors (2023)
  • Castle Connolly: New York Magazine Top Doctors (2005-2023)
  • Burkitt Medal (TCD)

Insurance Information

Understanding your insurance options is an important part of managing your cancer care. We have relationships with many common healthcare providers and plans.

Don't see your carrier or plan? We can help you understand your coverage.

If you don't have health insurance or are worried that your care may not be fully covered, our financial assistance programs may be able to help.

If you have questions about insurance, call us at 646-497-9176.

Make an Appointment

Women talking
New Patients
Scheduling an appointment is easy. Click or call 646-497-9053— we’re available 24 hours a day, 7 days a week
Make an Appointment
Current Patients
Request an appointment by logging in to MSK MyChart or calling your Care Team. If you are not enrolled in MSK MyChart, ask your Care Team to send you an invitation. You can also go to MSK MyChart and select “Sign up now.”

Contact and Location

Dr. O'Reilly sees patients at one location.

Office Phone
Location
New York, NY
Rockefeller Outpatient Pavilion
160 East 53rd Street New York NY 10022
Get Directions

Looking to see a doctor at a different location? See all MSK locations.

Colleagues

Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

See all Gastrointestinal Oncology Service doctors

Clinical Trials

Read more
Smiling doctors in the lab
Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

Search clinical trials

Research and Publications

Pant S, Wainberg ZA, Weekes CD, Furqan M, Kasi PM, Devoe CE, Leal AD, Chung V, Basturk O, VanWyk H, Tavares AM, Seenappa LM, Perry JR, Kheoh T, McNeil LK, Welkowsky E, DeMuth PC, Haqq CM, O’Reilly EM. Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial. Nat Med. 2024 Jan 9. doi: 10.1038/s41591-023-02760-3. Epub ahead of print. PMID: 38195752.

Wainberg ZA, Melisi D, Macarulla T, Pazo Cid R, Chandana SR, De La Fouchardière C, Dean A, Kiss I, Lee WJ, Goetze TO, Van Cutsem E, Paulson AS, Bekaii-Saab T, Pant S, Hubner RA, Xiao Z, Chen H, Benzaghou F, O’Reilly EM. NALIRIFOX versus nab-paclitaxel and gemcitabine in treatment-naive patients with metastatic pancreatic ductal adenocarcinoma (NAPOLI 3): a randomised, open-label, phase 3 trial. Lancet. 2023 Oct 7;402(10409):1272-1281. doi: 10.1016/S0140-6736(23)01366-1. Epub 2023 Sep 11. PMID: 37708904.

Park W, O’Connor CA, Bandlamudi C, Forman D, Chou JF, Umeda S, Reyngold M, Varghese AM, Keane F, Balogun F, Yu KH, Kelsen DP, Crane C, Capanu M, Iacobuzio-Donahue C, O’Reilly EM. Clinico-genomic characterization of ATM and HRD in Pancreas Cancer: Application for Practice. Clin Cancer Res. 2022 Aug 30:CCR-22-1483. doi: 10.1158/1078-0432.CCR-22-1483. Epub ahead of print. PMID: 36040493.

Read more

Katz MHG, Shi Q, Meyers J, Herman JM, Chuong M, Wolpin BM, Ahmad S, Marsh R, Schwartz L, Behr S, Frankel WL, Collisson E, Leenstra J, Williams TM, Vaccaro G, Venook A, Meyerhardt JA, O’Reilly EM. Efficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the Pancreas: The A021501 Phase 2 Randomized Clinical Trial. JAMA Oncol. 2022 Jul 14. doi: 10.1001/jamaoncol.2022.2319. Epub ahead of print. PMID: 35834226.

Publications on PubMed

Visit PubMed for a full listing of Dr. O'Reilly’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.

See all on PubMed

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Eileen M. O'Reilly discloses the following relationships and financial interests:

  • AbbVie
    Professional Services and Activities (Uncompensated)
  • Alligator Bioscience AB
    Professional Services and Activities
  • American Society of Clinical Oncology (ASCO)
    Professional Services and Activities
  • AstraZeneca
    Professional Services and Activities (Uncompensated)
  • AUTEM Medical, LLC
    Professional Services and Activities (Uncompensated)
  • Boehringer Ingelheim
    Professional Services and Activities (Uncompensated)
  • Bristol-Myers Squibb
    Professional Services and Activities
  • General Electric
    Professional Services and Activities
  • HMP Oncology Learning Network
    Professional Services and Activities
  • Hookipa Biotech
    Professional Services and Activities
  • Imedex, Inc.
    Professional Services and Activities
  • Ipsen
    Professional Services and Activities (Uncompensated)
  • Leap Therapeutics Inc.
    Professional Services and Activities (Uncompensated)
  • Merck & Co Inc.
    Professional Services and Activities (Uncompensated)
  • Merus
    Professional Services and Activities
  • Neogene Therapeutics Inc
    Professional Services and Activities (Uncompensated)
  • Novartis
    Professional Services and Activities
  • Research to Practice
    Professional Services and Activities
  • Revolution Medicines
    Professional Services and Activities (Uncompensated)
  • Syros Pharmaceuticals, Inc.
    Professional Services and Activities (Uncompensated)

If you’re a patient at MSK and would like more information about your doctor’s external relationships, please talk with your doctor.

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


View all disclosures

Related topics: