Medical oncologist Dr. Eileen O'Reilly

Eileen M. O'Reilly, MD

Gastrointestinal Medical Oncologist

Areas of Expertise

Conditions I Treat

  • Pancreatic cancer
  • Pancreatic neuroendocrine tumors
  • Gallbladder cancer

My Specialties

  • Immunotherapy
  • Clinical trials
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Dr. O'Reilly's Office Information
Languages: English
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Get to Know Me

I am a medical oncologist who cares for people with pancreatic and hepatobiliary (hep-uh-toh-BIL-ee-air-ee) cancers, including:

At Memorial Sloan Kettering Cancer Center (MSK), I work closely with a team of experts across medical areas. These include:

Together, we create a care plan that best treats each person’s cancer while honoring their personal wants and needs for cancer treatment. To achieve these goals, I communicate clearly and effectively with every patient, their family, and other team members. I strive for excellence in these areas as part of my commitment to offer the best possible care.

My research focuses on developing new therapies for pancreatic cancer, such as:

  • Gene-based treatments.
  • Immunotherapy (including vaccines).
  • Personalized treatments that target a cancer’s unique molecular makeup.

I also lead many clinical trials for people with this disease. Our hope is that this work leads to approved treatments that help people with pancreatic and other cancers live longer and have a better quality of life.

I co-direct a major federally-funded grant called the Specialized Program in Research Excellence (SPORE) for pancreatic cancer. This grant supports investigators using the latest molecular biology, immunotherapy and clinical advances to improve care for people with pancreatic cancer.

I have authored and co-authored more than 500 articles, editorials, and book chapters and am a highly cited researcher in my field. I also serve as Senior /Associate Editor for several major journals such as the Journal of Clinical Oncology and Clinical Cancer Research.

In addition to caring for patients and leading research, I am Chair of MSK’s Human Research Protection Program and the Institutional Review and Privacy Board. In this role, I work closely with a team of people to oversee how research is conducted at MSK.

Education is another important part of my work. I teach and mentor national and international oncology fellows, junior faculty, residents, house staff, and students. It’s an honor to have been recognized with many teaching awards for these efforts.

Outside of MSK, I work with groups and experts around the world to improve care for people with pancreas and hepatobiliary cancers. I am Co-Chair of the National Cancer Institute (NCI) Alliance Co-Operative Group Gastrointestinal Cancers Committee and a member of the NCI’s Gastrointestinal Cancers Steering Committee. These committees are involved in developing and overseeing federally-funded clinical trials in gastrointestinal cancers.

I also serve on the medical and/or scientific advisory board of various organizations and other national/international committees including:

  • Pancreatic Cancer Action Network
  • American Society of Clinical Oncology Guidelines Committee
  • European Society of Medical Oncology Guidelines Committee
  • National Pancreas Foundation
  • Hirshberg Foundation
  • PanKind Foundation

In my spare time, I enjoy being with my family, reading, classical music, traveling to Europe and Asia, cultivating plants, and watching films.

What I Do at MSK

I'm a gastrointestinal (GAS-troh-in-TES-tih-nul) medical oncologist, which is a cancer doctor who specializes in gastrointestinal (GI) cancers. This includes anal, colorectal, esophageal, gastric (stomach), liver, and pancreatic cancers. We also treat GI stromal tumors and neuroendocrine tumors.

  • Winthrop Rockefeller Endowed Chair of Medical Oncology
  • Chair, Human Research Protection Program and Institutional Review Board
  • Co-Director, Medical, David M. Rubenstein Center for Pancreatic Cancer Research
  • Section Head, HPB & Neuroendocrine Cancers
Areas of Expertise

Conditions I Treat

  • Pancreatic cancer
  • Pancreatic neuroendocrine tumors
  • Gallbladder cancer
  • Bile duct cancer (cholangiocarcinoma)
  • Primary liver cancer

My Specialties

  • Immunotherapy
  • Clinical trials
Education & Honors

Education

  • MD, Trinity College, Ireland

Residencies

  • Internal Medicine - St. James's Hospital

Fellowships

  • Internal Medicine/Medical Oncology - St. Vincent's Hospital (Ireland)
  • Medical Oncology - Memorial Sloan Kettering Cancer Center
  • Medicine - Cornell University Medical Center

Board Certifications

  • Internal Medicine (Ireland)

Awards and Honors

  • Castle Connolly: America’s Top Doctor (2005-2026)
  • Whitman Award for Clinical Excellence (2025)
  • Castle Connolly: Exceptional Women in Medicine (2019-2026)
  • Fellow of the American Society of Clinical Oncology (2024)
  • Top Doctors New York Metro Area, Castle Connolly (2005-2023)
  • Giant of Cancer Care, Gastrointestinal Cancer, OncLive (2023)
  • New York Magazine Top Doctors (2005-2025)
  • Burkitt Medal (TCD)

Insurance Information

Understanding your insurance options is an important part of managing your cancer care. We have relationships with many common healthcare providers and plans.

Don't see your carrier or plan? We can help you understand your coverage.

If you don't have health insurance or are worried that your care may not be fully covered, our financial assistance programs may be able to help.

If you have questions about insurance, call us at 646-497-9176.

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Contact and Location

Office Phone
Location
New York, NY
Rockefeller Outpatient Pavilion
160 East 53rd Street New York NY 10022
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Colleagues

Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

See all Gastrointestinal Oncology Service doctors

Clinical Trials

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Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

Search clinical trials

Research and Publications

Park W, O’Connor CA, ….. Iacobuzio-Donahue C, O’Reilly EM. Pembrolizumab and olaparib in homologous-recombination-deficient metastatic pancreatic cancer: the phase 2 POLAR trial. Nat Med. 2026 Mar 25. Epub ahead of print. PMID: 41882405.

Wainberg ZA, Weekes CD, …. Haqq CM, Pant S, O’Reilly EM. Lymph node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: phase 1 AMPLIFY-201 trial final results. Nat Med. 2025 Nov;31(11):3648-3653. Epub 2025 Aug 11. PMID: 40790272; PMCID: PMC12618236.

Varghese AM, Perry MA, ….. Bandlamudi C, O’Reilly EM. Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival. Nat Med. 2025 Feb;31(2):466-477. Epub 2025 Jan 3. PMID: 39753968; PMCID: PMC11835752.

 

Publications on PubMed

Visit PubMed for a full listing of Dr. O'Reilly’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.

See all on PubMed

Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Eileen M. O'Reilly discloses the following relationships and financial interests:

  • AbbVie
    Professional Services and Activities (Uncompensated)
  • American Society of Clinical Oncology (ASCO)
    Professional Services and Activities
  • AstraZeneca
    Professional Services and Activities (Uncompensated)
  • AUTEM Medical, LLC
    Professional Services and Activities (Uncompensated)
  • Boehringer Ingelheim
    Professional Services and Activities (Uncompensated)
  • HMP Oncology Learning Network
    Professional Services and Activities
  • Imedex, Inc.
    Professional Services and Activities
  • Research to Practice
    Professional Services and Activities
  • Revolution Medicines
    Professional Services and Activities (Uncompensated)
  • Syros Pharmaceuticals, Inc.
    Professional Services and Activities (Uncompensated)
  • Tango Therapeutics
    Professional Services and Activities

If you’re a patient at MSK and would like more information about your doctor’s external relationships, please talk with your doctor.

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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