For Patients & Caregivers
Juice Plus has not been shown to treat or prevent cancer.
Juice Plus is a dietary supplement that contains dried concentrates of fruits and vegetables. It has been studied for its antioxidant and cardiovascular effects. But more studies are needed. There are ongoing clinical studies of Juice Plus in cancer patients but it has not been proven to treat or prevent cancer. Juice Plus is not a substitute for fresh fruits and vegetables.
- To prevent and treat cancer
No scientific evidence supports this use.
- To prevent and manage heart disease
Small studies showed mixed results. Well designed clinical trials are needed.
- To reduce cold symptoms
One study shows taking capsules consist of juice powder concentrate of fruits and vegetables can reduce common cold symptoms and duration.
For Healthcare Professionals
Juice Plus (JP) is a formulation derived from a variety of fruits and vegetables and contains additional vitamins. It is marketed to complement daily diet based on the notion that people do not consume enough fruits and vegetables. Studies on bioavailability suggest that consumption of JP can increase serum levels of alpha-carotene, vitamin C, and folate (1)(2) but studies with other markers, such as lutein, alpha-tocopherol yielded mixed results. JP was shown comparable to standard vitamin C and E supplements (3) but it remains unclear if this product is nutritionally superior to fresh produce. JP was shown to decrease plasma homocysteine levels, a risk factor for cardiovascular disease (9)(1), but the results were not reproducible (4). Studies on cardiovascular effects, such as changes in blood pressure and cholesterol levels are inconclusive (5)(4). JP consumption is thought to reduce oxidative stress and DNA damage (10)(6)(2), and has been associated with a reduction in the symptoms of common cold (12).
Gastrointestinal distress (5) and hive-like rash (11) have been associated with intake of JP in clinical trials.
While there is ongoing research using JP in cancer patients, it has not been proven to prevent or treat cancers. Due to its antioxidant effects, JP may interfere with the actions of some chemotherapy drugs. Cancer patients should discuss use of supplements with their physicians. JP is not a substitute for fresh fruits and vegetables.
JP is thought to have antioxidant and immunomodulating properties. It reduces some biomarkers of oxidative stress but not others (6)(3)(2). Inflammatory cytokine TNF alpha production increased up to 8 weeks following consumption of JP but decreased after. It had no effect on other markers including IL-4, IL-6, superoxide dismutase or glutathione (6)(7)(8). JP decreased levels of plasma homocysteine, a risk factor for cardiovascular diseases (1)(9), but failed to show similar effect in another study (4). Intake of phytochemical antioxidants may have protective effect on endothelial function by preserving the bioactivity of nitric oxide (4). JP’s effects on regulating blood pressure are mixed. Consumption of fresh fruits and vegetables can lower cholesterol levels due to their high fiber content. But JP extract did not appreciably alter cholesterol levels (4)(5).
Case Report: Elevated liver function tests and interference with allopathic therapies. A 51-year-old woman with endometrial cancer experienced hepatotoxicity linked to the use of JP. The patient discontinued using the product and liver function tests normalized over 4 weeks (14).