- Nu Zhen Zi
- Glossy Privet
- Dong qing Zin
For Patients & Caregivers
Bottom Line: Ligustrum lucidum has not been shown to treat cancer in humans.
Ligustrum lucidum is a Chinese medicinal herb used to treat diminished eye sight, dizziness, fever, insomnia, and to increase immune function in cancer patients. In vitro studies have shown that it has antioxidative, antitumor, and immunomodulating effects. However, human data are lacking.
- Cancer treatment
In vitro studies have shown that Ligustrum lucidum has anticancer properties. But clinical evidence is lacking.
Data from laboratory studies indicate that Ligustrum lucidum can change immune response.
- Eye sight
Ligustrum lucidum is used in Chinese medicine to treat poor eye sight but there is no clinical evidence to support this.
There are no data to support this use although Ligustrum lucidum is used to treat dizziness in Chinese medicine.
This use is not backed by scientific evidence.
There are no data to support this use.
One in vitro study has shown that Ligustrum lucidum is effective against certain viruses.
For Healthcare Professionals
Ligustrum lucidum is a Chinese medicinal plant that is often used in combination with other herbs in botanical formulas. There are several species of Ligustrum that are thought to have different medicinal properties (2)(3). Traditionally, the plant is used to treat diminished eye sight, dizziness, fever, insomnia, and lower back pain. Some herbalists also use it to treat side effects caused by chemotherapy and to increase immunity in cancer patients. In vitro studies have shown that the fruits of Ligustrum lucidum have antitumor (4)(5)(6), immunomodulatory (7)(13), antioxidative (1), antiviral (8), antimutagenic (9)(10), hepatoprotective (11), and antidiabetic (12) properties.
However, human data are lacking.
There are no reports of adverse effects from the use of Ligustrum.
- Triterpenoids: Oleanolic Acid, Osolic Acid Oleuropenin Denamite
- Secoiridoid Glucosides: Lucidumoside, Oleoside dimethyl ether, Neonuezhenide, Oleuropein, Ligustrosides A and B, Isoneuzhenide, Lucidumosides A, B, C, and D, isoligustrosidic acid, 6’-O-trans-cinnamoyl 8-epikingisidic acid, 6’-O-cis-cinnamoyl 8-epikingisidic acid, oleopolynuzhenide A, nuzhenals A and B
Ligustrum lucidum is thought to exert antitumor properties by modulating immune response and by reverting macrophage suppression brought about by tumors (4). Another in vitro study has shown that such effects may also be due to increase in phagocytes and lymphokine-activated killer (LAK) cells (5). The secoiridoid glucosides in Ligustrum fruit showed strong antioxidant effect against free radical-associated hemolysis of erythrocytes (1). One of the secoiridoid glucosides, oleuropein, also demonstrated significant antiviral activity against respiratory syncytial virus (RSV) and parainfluenza type 3 virus (Para 3) although the mechanism is not known (8). The hepatoprotective effects of Ligustrum are due to the oleanolic acid and are thought to be mediated by an increase in hepatic glutathione regeneration capacity (11).