Wheat germ extract

Wheat germ extract

Wheat germ extract

Common Names

  • Fermented wheat germ extract
  • MSC (Code Name)

For Patients & Caregivers

Fermented wheat germ was shown to improve quality of life in cancer patients. More studies are needed.

Fermented wheat germ extract (WGE) was developed by Mate Hidvegi, a Hungarian chemist, in the 1990s. It should not be confused with wheat germ oil. WGE is used as a dietary supplement by cancer patients in Hungary to improve quality of life. Laboratory studies show that WGE may have anticancer properties. Results from some clinical trials suggest WGE improves quality of life, but cancer patients should consult their physicians before taking WGE.

  • Cancer treatment
    WGE was shown to improve quality of life in cancer patients. More data are needed to establish its use.
  • Autoimmune disorders
    Animal studies show that WGE is beneficial, but human data are lacking.
  • Immunostimulation
    Data from test tube and observation studies show that WGE can regulate the immune system.
  • You are pregnant or nursing.
  • You had an organ or tissue transplant.
  • You have bleeding, ulcers of the stomach and intestine, or severe absorption problems.
  • You have sensitivity to gluten.
  • You are fructose intolerant.
  • You are having barium X-ray contrast tests. Discontinue 2 days before and after test.

Mild and infrequent side effects include diarrhea, nausea, flatulence, soft stool, constipation, dizziness.
Wheat germ extract may have estrogen receptor activity. Patients with hormone-sensitive cancers should consult with a physician before using WGE.

WGE should be taken at least 2 hours before or after consuming vitamin C.

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For Healthcare Professionals

Avemar, Avé, AvéULTRA, AWGE, OncoMAR

Fermented wheat germ extract (WGE) was developed in the 1990s by Hungarian chemist Mate Hidvegi. It should not be confused with wheat germ oil. WGE is used as a dietary supplement by cancer patients in Hungary to improve quality of life (QoL).

Results from in vitro studies show that WGE has anticancer (1) (2) (3) (4) (5) (19), antimetastatic (6), and immunomodulatory (2) (7) effects. Although it appears to increase estrogen receptor (ER) activity, WGE enhanced efficacy of tamoxifen, an ER antagonist, in ER+ breast cancer cells (8) as well as cisplatin in ovarian cancer cell lines (5). Animal models suggest WGE can reduce cardiovascular symptoms due to chronic hypertension, diabetes, and obesity (9), mitigate symptoms associated with lupus (10), and that its antitumor effect is comparable to other endocrine treatments (11).

Data from pilot studies indicate a beneficial role for WGE in patients with colorectal cancer (12) and in reducing treatment-associated febrile neutropenia in pediatric cancer patients (13). It also prolonged survival of patients with melanoma when used with chemotherapy (14) (15). However, these effects must be confirmed by large-scale, well-designed clinical trials.

Because it potentiates estrogen receptor activity, patients with hormone-sensitive cancers should use WGE with caution.

  • Autoimmune disorders
  • Cancer treatment
  • Immunomodulation

Benzoquinone compounds are thought to be the active components of WGE (5). In vitro, WGE attenuates cell cycle progression from G2-M to G0-G1 phase, reduces ribonucleotide reductase activity (3) (4), and stimulates immune function via increased natural killer (NK) cell activity and intercellular adhesion molecule 1 (ICAM-1) expression (16) (17). It also increases tumor necrosis factor (TNF) and cytokine production by activating metabolic pathways involved in tumor cell death (14). WGE demonstrated cytotoxic effects on human lymphoma cells by inducing apoptosis (4) and against ovarian cancer cells via poly(ADP-ribose) polymerase (PARP)-1 and PARP-12 expression (5). It was also shown to regulate tumor cell proliferation by inhibiting glycolysis and pentose cycle enzymes (19), and induce apoptosis through caspase-3-mediated PARP cleavage (7).

  • Pregnant and nursing women.
  • Patients with hormone-sensitive cancers, as it may have estrogen-receptor activity.
  • Patients with organ or tissue transplants.
  • Patients with bleeding gastric or duodenal ulcers, enteritis/colitis, or malabsorption syndrome.
  • Patients with sensitivity to gluten and those with fructose intolerance.
  • The manufacturer recommends discontinuing Avemar usage 2 days before barium X-ray contrast examinations and resume 2 days after procedure.
     (8) (18)

Mild, infrequent: diarrhea, nausea, flatulence, soft stool, constipation, dizziness (15) (18)

WGE should be taken at least 2 hours before or after consuming vitamin C (18).

  1. Zalatnai A, Lapis K, Szende B, et al. Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats. Carcinogenesis. Oct 2001;22(10):1649-1652.

  2. Jakab F, Mayer A, Hoffmann A, et al. First clinical data of a natural immunomodulator in colorectal cancer. Hepatogastroenterology. Mar-Apr 2000;47(32):393-395.

  3. Judson PL, Al Sawah E, Marchion DC, et al. Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of its activity. Int J Gynecol Cancer. Jul 2012;22(6):960-967.

  4. Hidvegi M, Raso E, Tomoskozi-Farkas R, et al. Effect of Avemar and Avemar + vitamin C on tumor growth and metastasis in experimental animals. Anticancer Res. Jul-Aug 1998;18(4a):2353-2358.

  5. Marcsek Z, Kocsis Z, Jakab M, et al. The efficacy of tamoxifen in estrogen receptor-positive breast cancer cells is enhanced by a medical nutriment. Cancer Biother Radiopharm. Dec 2004;19(6):746-753.

  6. Iyer A, Brown L. Fermented wheat germ extract (avemar) in the treatment of cardiac remodeling and metabolic symptoms in rats. Evid Based Complement Alternat Med. 2011;2011:508957.

  7. Tejeda M, Gaal D, Szucs I, et al. Avemar inhibits the growth of mouse and human xenograft mammary carcinomas comparable to endocrine treatments. ASCO Meeting Abstracts. June 21, 2007;25(18_suppl):21132.

  8. Jakab F, Shoenfeld Y, Balogh A, et al. A medical nutriment has supportive value in the treatment of colorectal cancer. Br J Cancer. Aug 4 2003;89(3):465-469.

  9. Garami M, Schuler D, Babosa M, et al. Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients. J Pediatr Hematol Oncol. Oct 2004;26(10):631-635.

  10. Telekes A, Kiss-Toth E, Nagy T, et al. Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation. Ann N Y Acad Sci. Jun 2005;1051:515-528.

  11. Telekes A, Hegedus M, Chae CH, et al. Avemar (wheat germ extract) in cancer prevention and treatment. Nutr Cancer. 2009;61(6):891-899.

  12. Biropharma USA Inc. AWGE Side Effects. 2014; http://www.avemarwge.us/side_effects. Accessed February 19, 2014.

  13. Shibuya N1, Inoue KI, Tanaka G. et al. Augmented Pentose Phosphate Pathway Plays Critical Roles in Colorectal Carcinomas. Oncology. 2015 Jan 14. [Epub ahead of print]

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